A5005605092- Immune Response and Inflammation
- Immunotherapy and Immune Responses
- NF-κB Signaling Pathways
- interferon and immune responses
- T-cell and B-cell Immunology
- Cytokine Signaling Pathways and Interactions
- Immune Cell Function and Interaction
- Ubiquitin and proteasome pathways
- IL-33, ST2, and ILC Pathways
- Immune cells in cancer
- Cancer Immunotherapy and Biomarkers
- Cancer-related Molecular Pathways
- Heat shock proteins research
- Epigenetics and DNA Methylation
- Gut microbiota and health
- Neuroinflammation and Neurodegeneration Mechanisms
- Protein Tyrosine Phosphatases
- MicroRNA in disease regulation
- Chemokine receptors and signaling
- Melanoma and MAPK Pathways
- Cancer Mechanisms and Therapy
- RNA Interference and Gene Delivery
- Thermal Regulation in Medicine
- Inflammasome and immune disorders
- Neonatal Respiratory Health Research
Shanghai University of Traditional Chinese Medicine
2023-2024
Second Military Medical University
2013-2023
Shandong Provincial QianFoShan Hospital
2021-2023
Shandong First Medical University
2021-2023
Institute for Rheumatic Diseases (Japan)
2023
University Medical Center Freiburg
2014
Shanghai Changzheng Hospital
2009
Zhejiang University
2003-2006
Tsinghua University
2005
Molina Center for Energy and the Environment
2005
Abstract Upon recognition of viral components by pattern receptors, including TLRs and retinoic acid-inducible gene I (RIG-I)- like helicases, cells are activated to produce type IFN proinflammatory cytokines. These pathways tightly regulated host prevent inappropriate cellular response, but viruses can down-regulate these for their survival. Recently, identification negative regulators cytoplasmic RNA-mediated antiviral signaling, especially the RIG-I pathway, attract much attention....
Summary Toll‐like receptors (TLR) are sentinel capable of recognizing pathogen‐associated molecule patterns (PAMP) such as lipopolysaccharide (LPS) and CpG‐containing oligonucleotides (CpG ODN). TLR2 TLR4 major for Gram‐positive Gram‐negative bacterial cell wall components, respectively. TLR9 is necessary CpG signalling. LPS or ODN can activate immature dendritic cells (DC) induce DC maturation characterized by production cytokines, up‐regulation co‐stimulatory molecules, increased ability...
Abstract Ubiquitination is one of the most prevalent protein posttranslational modifications. Here, we show that E3 ligase Nedd4l positively regulates antiviral immunity by catalyzing K29-linked cysteine ubiquitination TRAF3. Deficiency significantly impairs type I interferon and proinflammatory cytokine production induced virus infection both in vitro vivo. deficiency inhibits virus-induced TRAF3, binding between TRAF3 TBK1, subsequent phosphorylation TBK1 IRF3. directly interacts with...
Oxidative stress is considered the major cause of tissue injury after cerebral ischemia. The nuclear factor erythroid 2-related 2 (Nrf2) pathway one most important defensive mechanisms against oxidative stresses and has been confirmed as a target for stroke treatment. Thus, we desired to find new Nrf2 activators test their neuronal protective activity both in vivo vitro.The herb-derived compound, Britanin, potent inducer system. Britanin can induce expression enzymes reverse oxygen-glucose...
A leading cause of death worldwide is sepsis that develops as a dysregulated immune response to infection. Serious infection caused by methicillin-resistant Staphylococcus aureus (MRSA) increases the difficulty treatment in septic patients. Host-directed therapy (HDT) an emerging approach for bacterial infections. Xuebijing injection (XBJ), commercialized injectable prescription from traditional Chinese medicine, has been used adjuvant with history 15 years. Whether it plays protective role...
Summary Heat stress can alert innate immunity by inducing proteins such as heat‐shock (HSPs). However, it remains unclear whether heat affects the activation of antigen‐presenting cell (APC) in response to pathogen‐associated molecule patterns (PAMPs) directly regulating pathogen recognition receptors (PRRs). As an important kind PRRs, Toll‐like (TLRs) play critical roles immune system. In this study, we demonstrated that shock up‐regulated expression HSP70 well TLR2 and TLR4 monocytes. The...