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Contact & Profiles
A5020464512
Research Areas
- NF-κB Signaling Pathways
- Whipple's Disease and Interleukins
- IL-33, ST2, and ILC Pathways
- interferon and immune responses
- Psoriasis: Treatment and Pathogenesis
- Cytokine Signaling Pathways and Interactions
- Ubiquitin and proteasome pathways
- Melanoma and MAPK Pathways
Second Military Medical University
2016-2021
Abstract Ubiquitination is one of the most prevalent protein posttranslational modifications. Here, we show that E3 ligase Nedd4l positively regulates antiviral immunity by catalyzing K29-linked cysteine ubiquitination TRAF3. Deficiency significantly impairs type I interferon and proinflammatory cytokine production induced virus infection both in vitro vivo. deficiency inhibits virus-induced TRAF3, binding between TRAF3 TBK1, subsequent phosphorylation TBK1 IRF3. directly interacts with...
10.1038/s41467-021-21456-1
article
EN
cc-by
Nature Communications
2021-02-19
10.1016/j.molimm.2020.04.006
article
EN
Molecular Immunology
2020-04-27
10.1016/j.molimm.2016.02.006
article
EN
Molecular Immunology
2016-02-20
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