A5101586141- Birth, Development, and Health
- Reproductive Biology and Fertility
- Ovarian function and disorders
- Pregnancy and preeclampsia studies
- Assisted Reproductive Technology and Twin Pregnancy
- Reproductive System and Pregnancy
- Gestational Diabetes Research and Management
- Endometriosis Research and Treatment
- Ion channel regulation and function
- Epigenetics and DNA Methylation
- Prenatal Screening and Diagnostics
- Adipose Tissue and Metabolism
- Receptor Mechanisms and Signaling
- Estrogen and related hormone effects
- Genetic and Clinical Aspects of Sex Determination and Chromosomal Abnormalities
- Sperm and Testicular Function
- RNA modifications and cancer
- Nitric Oxide and Endothelin Effects
- Ion Transport and Channel Regulation
- Neuroscience and Neuropharmacology Research
- Genetic Syndromes and Imprinting
- Ovarian cancer diagnosis and treatment
- Liver Disease Diagnosis and Treatment
- Cardiac electrophysiology and arrhythmias
- Regulation of Appetite and Obesity
Zhejiang University
2016-2025
Women's Hospital, School of Medicine, Zhejiang University
2010-2025
Chinese Academy of Medical Sciences & Peking Union Medical College
2022-2025
Hangzhou Medical College
2025
Sichuan Provincial Hospital of Traditional Chinese Medicine
2025
Ministry of Education of the People's Republic of China
2014-2024
Obstetrics and Gynecology Hospital of Fudan University
2023
Sheng Jing Hospital
2023
International Peace Maternity & Child Health Hospital
2016-2020
Shanghai Jiao Tong University
2016-2020
Gestational diabetes mellitus (GDM) has been shown to be associated with high risk of in offspring. However, the mechanisms involved and possibilities transgenerational transmission are still unclear. We intercrossed male female adult control first-generation offspring GDM (F1-GDM) mice obtain second-generation (F2) four groups: C♂-C♀, C♂-GDM♀, GDM♂-C♀, GDM♂-GDM♀. found that birth weight significantly increased F2 through paternal line impaired glucose tolerance (IGT). Regardless from F1-GDM...
Summary Increased fat mass and redistribution are commonly observed in aging populations worldwide. Although decreased circulating levels of sex hormones, androgens oestrogens have been observed, the exact mechanism accumulation during remains obscure. In this study, receptor follicle‐stimulating hormone ( FSH ), a gonadotropin that increases sharply persistently with both males females, is functionally expressed human mouse tissues adipocytes. Follicle‐stimulating was found to promote lipid...
Abstract Context Accurate methods for early gestational diabetes mellitus (GDM) (during the first trimester of pregnancy) prediction in Chinese and other populations are lacking. Objectives This work aimed to establish effective models predict GDM. Methods Pregnancy data 73 variables during were extracted from electronic medical record system. Based on a machine learning (ML)-driven feature selection method, 17 selected GDM prediction. To facilitate clinical application, 7 17-variable panel....
Abstract Accumulating evidence suggests a role of bisphenol A (BPA) in metabolic disorders. However, the underlying mechanism is still unclear. Using mouse BPA exposure model, we investigated effects long-term on lipid metabolism and mechanisms. The male mice exposed to (0.5 μg /kg/day, human relevant dose) for 10 months exhibited significant hepatic accumulation triglycerides cholesterol. liver cells from BPA-exposed showed significantly increased expression levels genes related synthesis....
Context: There are increasing concerns that a disrupted endocrine environment may disturb the growth of fetus. Assisted reproductive technology (ART) situates gamete/embryo in supraphysiological estradiol (E2) and, thus, provides an ideal model to investigate this problem. Objective: Our objective was whether maternal high-E2 first trimester increases risks low birth weight (LBW) and small-for-gestational-age (SGA) birth. Methods: In total, 8869 singletons born after fresh embryo transfer...
Context:The elevated low-density-lipoprotein cholesterol (LDL-C) in menopausal women is associated with higher risks of cardiovascular diseases.
Polycystic ovary syndrome (PCOS) is one of the most common female endocrine disorders and a leading cause subfertility. The mechanism underlying pathophysiology PCOS remains to be illustrated. Here, we identify two alternative splice variants (ASVs) androgen receptor (AR), insertion deletion isoforms, in granulosa cells (GCs) ∼62% patients with PCOS. AR ASVs are strongly associated remarkable hyperandrogenism abnormalities folliculogenesis, absent from all control subjects without...
Polycystic ovary syndrome (PCOS), whose etiology remains uncertain, is a highly heterogenous and genetically complex endocrine disorder. The aim of this study was to identify differentially expressed genes (DEGs) in granulosa cells (GCs) from PCOS patients make epigenetic insights into the pathogenesis PCOS. Included were 110 women with 119 normal ovulatory cycles undergoing vitro fertilization acting as control group. RNA-seq identified 92 DEGs unique GCs comparison Bioinformatic analysis...
Reducing cardiovascular disease burden among women remains challenging. Epidemiologic studies have indicated that polycystic ovary syndrome (PCOS), the most common endocrine in of reproductive age, is associated with an increased prevalence and extent coronary artery disease. However, mechanism through which PCOS affects cardiac health unclear.
Follicle-stimulating hormone (FSH) is involved in mammalian reproduction via binding to FSH receptor (FSHR). However, several studies have found that and FSHR play important roles extragonadal tissue. Here, we identified the expression of human mouse pancreatic islet β-cells. Blocking signaling by Fshr knock-out led impaired glucose tolerance owing decreased insulin secretion, while high levels caused insufficient secretion as well. In vitro, orchestrated glucose-stimulated (GSIS) a bell...
The contribution of small-conductance (SK Ca ) and intermediate-conductance 2+ -activated K + (IK channels to the generation nitric oxide (NO) by -mobilizing stimuli was investigated in human umbilical vein endothelial cells (HUVECs) combining single-cell microfluorimetry with perforated patch-clamp recordings monitor agonist-evoked NO synthesis, cytosolic transients, membrane hyperpolarization real time. ATP or histamine evoked reproducible elevations synthesis , as judged...
The recommendations for the diagnosis of stage 1 hypertension were recently revised by American Heart Association primarily based on its impact cardiovascular disease risks. Whether newly diagnosed impacts pregnancy complications remain poorly defined. We designed a retrospective cohort study to investigate associations detected in early gestation (<20 weeks) with risks adverse outcomes stratified prepregnancy body mass index. A total 47 874 women singleton live births and blood pressure...
Recent data have led us to hypothesize that selective activation of endothelial small- and/or intermediate-conductance, calcium-activated potassium channels (SK(Ca) and IK(Ca) channels, respectively) by the opener compounds NS309 DCEBIO would augment stimulated nitric oxide (NO) synthesis vasodilation in resistance arteries. Experimentally, ATP-evoked changes membrane potential, cytosolic Ca(2+), NO were recorded patch clamp microfluorimetry single human cells. Agonist-evoked inhibition...
BACKGROUND: The impact of different ovarian stimulation (OS) protocols on endometrial receptivity remains controversial. In this study, the effects OS expression integrin β3 subunit and leukaemia-inhibitory factor (LIF) during implantation window rate in mice were investigated. METHODS: Three used, involving either pregnant mare's serum gonadotrophin (PMSG) alone, PMSG plus GnRH agonist or antagonist. Uterus samples collected at 48 h after ovulation detected with immunohistochemistry,...
Accumulating evidence suggests that aquaporins (AQP) can facilitate cell migration, invasion, and proliferation in tumor development addition to water transport.The aim of this study was examine AQP2 expression the endometrial tissues from patients with carcinoma (EC) determine roles mechanisms estrogen-related adhesion, Ishikawa (IK) cells.AQP2 levels were measured human cells estradiol (E(2))-treated IK cells, estrogen-response element identified. After blocking down up-regulating...
Aquaporin-1 (AQP1) has been proposed as a mediator of estrogen-induced angiogenesis in human breast cancer and endometrial cancer. Elucidation the molecular mechanisms governing AQP1-mediated, may contribute to an improved understanding tumor development.Our objective was identify estrogen-response element (ERE) promoter Aqp1 gene investigate effects AQP1 on tubulogenesis vascular endothelial cells.The study conducted university hospital eastern China.Immunohistological, real-time PCR...
STUDY QUESTIONDo any mutations in growth differentiation factor 9 (GDF9) have a role diminished ovarian reserve (DOR) young women?
Abstract Accumulating evidence suggests that aquaporins (AQPs) may facilitate tumor development. The molecular pathways connecting the pathological functions of AQPs are unclear and need to be better defined. This study aimed investigate whether AQP3, one expressed highly in breast cancer, had any clinical implication estrogen-receptor (ER) positive cancer explore regulatory mechanisms AQP3 estrogen-related progression. Here we show is an important enforcer migration invasion cancer. We, for...