A5101674179- Neuroscience and Neuropharmacology Research
- Neurogenesis and neuroplasticity mechanisms
- Birth, Development, and Health
- Molecular Sensors and Ion Detection
- Metal-Organic Frameworks: Synthesis and Applications
- Barrier Structure and Function Studies
- Neuroinflammation and Neurodegeneration Mechanisms
- Pharmacological Effects and Toxicity Studies
- Advanced Nanomaterials in Catalysis
- Lymphoma Diagnosis and Treatment
- Epilepsy research and treatment
- Machine Learning in Bioinformatics
- Genomics, phytochemicals, and oxidative stress
- Preterm Birth and Chorioamnionitis
- Gestational Diabetes Research and Management
- Inflammasome and immune disorders
- Peptidase Inhibition and Analysis
- Cancer survivorship and care
- Endometrial and Cervical Cancer Treatments
- Cancer, Stress, Anesthesia, and Immune Response
- Ovarian cancer diagnosis and treatment
- Stroke Rehabilitation and Recovery
- Genetics and Neurodevelopmental Disorders
- Nitric Oxide and Endothelin Effects
- Cancer-related molecular mechanisms research
Nanjing Medical University
2019-2025
Second Affiliated Hospital of Nanjing Medical University
2025
Chinese Academy of Sciences
2022
Center for Excellence in Molecular Cell Science
2022
China Pharmaceutical University
2004-2022
Huaibei Normal University
2020-2021
People’s Hospital of Rizhao
2021
Qilu Hospital of Shandong University
2021
Harbin Medical University
2014-2020
Tohoku University
2018
A brain–blood barrier permeable probe was developed for fluorogenically sensing nitrosative stress caused by brain vascular injury.
The comorbidity of autism spectrum disorder and anxiety is common, but the underlying circuitry poorly understood. Here, Tmem74
The death signaling complex comprising extrasynaptic NMDAR and TRPM4 plays a pivotal role in the pathogenesis of ischemic stroke. Targeting protein-protein interactions between represents promising therapeutic strategy for Herein, we describe discovery novel series NMDAR/TRPM4 interaction interface inhibitors aimed at enhancing neuroprotective efficacy optimizing pharmacokinetic profiles. representative compound
Aim To estimate epidemiological risk factors for cerebral palsy (CP) in children. Methods A N:M matched case control study was conducted 114 persons with CP and 1286 controls. Relevant data were collected using a maternal self‐design questionnaire. Univariate logistic regression multivariate conditional analyses performed SPSS. Results analysis has yielded 20 significant CP. Advanced age (30 years or older) at childbirth (adjusted odds ratio (OR) 1.63, 95% confidence interval (CI)...
Primary pleural lymphoma is rare and has been described in association with human immunodeficiency virus (HIV) infection or pyothorax. We report a case of primary 73-year-old man who presented chest pain no history HIV Chest imaging showed thickening effusion. Thoracoscopic biopsy was performed. Histopathological immunohistochemical examinations conformed to that diffuse large B-cell lymphoma. Physicians should be aware this location implement thoracoscopy as soon possible.
This study aimed to investigate the correlation of anxiety/depression with clinicopathological features, and association degrees overall survival (OS) in surgical colorectal cancer (CRC) patients. Three hundred eighty-one CRC patients were consecutively enrolled underwent adjuvant chemotherapy accordingly. Anxiety depression assessed by Hospital Depression Scale (HADS). Patients no, minor, intermediate major anxiety 249 (65.4%), 79 (20.7%), 37 (9.7%) 16 (4.2%), respectively, 231 (60.6%), 73...
Severe anorexia limits the clinical application of cisplatin, and even leads to discontinuation treatment. However, mechanisms underlying cisplatin-induced are unknown. Herein, we demonstrated that cisplatin could affect neuronal gamma oscillations induce abnormal theta-gamma phase-amplitude coupling in arcuate nucleus (Arc) hypothalamus, these findings were associated with significantly decreased food intake weight loss mice. Chemogenetic activation AgRP neurons Arc reversed reduction We...
This study aims to investigate the mechanism by which magnesium sulfate regulates miR-218-5p/HMGB-pathway-mediated apoptosis of vascular endothelial cells (VECs) in rats with preeclampsia (PE).Twenty pregnant were randomly divided into four groups: normal, PE, MgSO4, and high-mobility group protein B1 (HMGB1)-agomir groups. On 14th day each rat's pregnancy, endotoxin was used establish a PE model HMGB1-agomir Then, MgSO4 groups treated sulfate. Finally, HMGB1 overexpression performed only...
Ischemic stroke is a significant threat to human health. Currently, there lack of effective treatments for stroke, and progress in new neuron-centered drug target development relatively slow. On the other hand, studies have demonstrated that brain microvascular endothelial cells (BMECs) are crucial components neurovascular unit play pivotal roles ischemic progression. To better understand complex multifaceted BMECs regulation pathophysiology facilitate BMEC-based discovery, we utilized...
Four new coordination polymers, namely [Cd(OBA)(H2O)3]n (1), [Zn2(OBA)2(PBHB)2]n (2), [Mn(OBA)(BBHB)2]n (3), and [Co(MIP)(BPP)]n (4) (H2OBA = 4-oxyacetate-benzoic acid, PBHB 1,1′-(1,3-propanediyl)bis-1H-benzimidazole, BBHB 1,1′-(1,4-butanediyl)bis-1H-benzimidazole, H2MIP 5-methylisophthalic BPP 1,3-bis(4-pyridyl)propane)), were prepared structurally characterized by single-crystal X-ray diffraction. In complex 1, the Cd(II) atoms are bridged OBA2− anions to give 1D zigzag chain, chains...
This study aimed to investigate the effect of a caregiver intensive education program (CIEP) on anxiety, depression, and quality life (QOL) in patients with drug-resistant temporal lobe epilepsy mesial sclerosis (TLE-MTS) who underwent cortico-amygdalohippocampectomy (CAH). Ninety TLE-MTS CAH their caregivers were recruited randomly allocated CIEP group or control as 1:1 ratio. Caregivers received routine guidance/education (control group). Anxiety/depression QOL at month (M)0, M1, M3, M6...
<abstract> <p>Lung cancer is a predominant cause of global cancer-related mortality, highlighting the urgent need for enhanced diagnostic and therapeutic modalities. With integration artificial intelligence (AI) into clinical practice, new horizon in lung care has emerged, characterized by precision both diagnosis treatment. This review delves AI's transformative role this domain. We elucidate significant contributions to imaging, pathology, genomic diagnostics, underscoring its...
Extramedullary plasmacytomas are rare tumors. To the best of our knowledge, only very few cases have been previously reported on positron emission tomography (PET) with glucose analog 2-deoxy-2-[F-18] fluoro-D-glucose (F-18 FDG), which showed markedly increased F-18 FDG accumulation in primary lesions. We present a new case PET/CT images showing low uptake nasopharynx plasmacytoma. Clinicians should be aware this phenomenon and potential for false negatives PET/CT.