A5102710269- Hearing, Cochlea, Tinnitus, Genetics
- Manufacturing Process and Optimization
- Vestibular and auditory disorders
- Product Development and Customization
- Ion Channels and Receptors
- Plant Molecular Biology Research
- Skin and Cellular Biology Research
- Neuroscience and Neuropharmacology Research
- Tropical and Extratropical Cyclones Research
- Genetics, Aging, and Longevity in Model Organisms
- Nicotinic Acetylcholine Receptors Study
- Environmental Changes in China
- Neurological Disorders and Treatments
- Flexible and Reconfigurable Manufacturing Systems
- Neurological Disease Mechanisms and Treatments
- Biochemical effects in animals
- RNA Research and Splicing
Nanjing Medical University
2020-2025
Second Affiliated Hospital of Nanjing Medical University
2025
Nanjing Drum Tower Hospital
2012-2024
State Key Laboratory of Pharmaceutical Biotechnology
2023
Model Animal Research Center
2012-2023
Nanjing University
2009-2023
Sichuan University of Science and Engineering
2010
Nanjing University of Science and Technology
2009
Aminoglycoside-induced hair cell (HC) loss is one of the most important causes hearing loss. After entering inner ear, aminoglycosides induce production high levels reactive oxygen species (ROS) that subsequently activate apoptosis in HCs. Citicoline, a nucleoside derivative, plays therapeutic role central nervous system injury and neurodegenerative disease models, including addictive disorders, stroke, head trauma, cognitive impairment elderly, has been widely used clinic as an FDA approved...
The death signaling complex comprising extrasynaptic NMDAR and TRPM4 plays a pivotal role in the pathogenesis of ischemic stroke. Targeting protein-protein interactions between represents promising therapeutic strategy for Herein, we describe discovery novel series NMDAR/TRPM4 interaction interface inhibitors aimed at enhancing neuroprotective efficacy optimizing pharmacokinetic profiles. representative compound
Striatin-interacting protein 1 ( Strip1 ) is a core component of the striatin interacting phosphatase and kinase (STRIPAK) complex, which involved in embryogenesis development, circadian rhythms, type 2 diabetes, cancer progression. However, expression role mammalian cochlea remains unclear. Here we studied function mouse by using knockout mice. We first found that mRNA increases as mice age starting from postnatal day (P) 3 reaches its highest level at P30 can be detected immunofluorescent...
Cingulin (CGN) is a cytoskeleton-associated protein localized at the apical junctions of epithelial cells. CGN interacts with major cytoskeletal filaments and regulates RhoA activity. However, physiological roles in development human diseases are currently unknown. Here, we report multi-generation family presenting autosomal dominant non-syndromic hearing loss (ADNSHL) that co-segregates heterozygous truncating variant, c.3330delG (p.Leu1110Leufs*17). normally expressed cell organ Corti,...
The structural homeostasis of the cochlear hair cell membrane is critical for all aspects sensory transduction, but regulation its maintenance not well understood. In this report, we analyzed cells mice with specific deletion myosin light chain kinase (MLCK) in inner cells. MLCK-deficient showed impaired hearing, a 5- to 14-dB rise auditory brainstem response (ABR) thresholds clicks and tones different frequencies significant decrease amplitude ABR waves. mutant produced several ball-like...
Nowadays, manufacturers are faced with severe challenges to response rapidly changing demands and meet various customers’ needs respect production volume product profile. Reconfigurable manufacturing paradigm was proposed as an advanced philosophy enhance the adaptability flexibility of sys-tems. By physical logical reconfiguration, Manufacturing System (RMS) is able fulfil in a cost-effective way by making full use resources currently available. This paper focuses on studying...
Information promotes and boosts up the competion of enterprises;Information integration is an important content. Characteristic single-piece small-lot different from other manufacture mode, so its information others too. The paper aims at questions, analyses content relation based on small-lot, brings forward flow BOM emphasizes methods that adapt to improve feasibility plan.