A5055182003- Natural product bioactivities and synthesis
- Drug Transport and Resistance Mechanisms
- Pharmacogenetics and Drug Metabolism
- Phytochemistry and Biological Activities
- Pharmacological Effects of Natural Compounds
- Inflammatory mediators and NSAID effects
- Antibiotics Pharmacokinetics and Efficacy
- Cancer therapeutics and mechanisms
- Chromatography in Natural Products
- Ginseng Biological Effects and Applications
- Traditional Chinese Medicine Analysis
- Bioactive natural compounds
- Flavonoids in Medical Research
- Analytical Chemistry and Chromatography
- Genomics, phytochemicals, and oxidative stress
- Polysaccharides and Plant Cell Walls
- Hearing, Cochlea, Tinnitus, Genetics
- Berberine and alkaloids research
- Phytochemical Studies and Bioactivities
- Plant-based Medicinal Research
- Phytochemicals and Antioxidant Activities
- Antibiotic Resistance in Bacteria
- Phytochemistry and Bioactive Compounds
- Cancer-related molecular mechanisms research
- Food Quality and Safety Studies
Nanjing Drum Tower Hospital
2021-2025
South China University of Technology
2024-2025
Texas Southern University
2017-2024
University of Houston
2011-2020
Iowa State University
2020
Jiangsu University
2018-2020
Affiliated Hospital of Jiangsu University
2018-2020
Zhejiang Sci-Tech University
2019-2020
Peking University
2019
Peking University Cancer Hospital
2019
Aging, noise, and ototoxic drug-induced hair cell (HC) loss are the major causes of sensorineural hearing loss. Aminoglycoside antibiotics commonly used in clinic, but these often have side effects due to accumulation oxygen-free radicals subsequent induction HC apoptosis. Blebbistatin is a myosin II inhibitor that regulates microtubule assembly myosin-actin interactions, most research has focused on its ability modulate cardiac or urinary bladder contractility. By regulating cytoskeletal...
Abstract The Hippo/Yes-associated protein (YAP) signaling pathway has been shown to be able maintain organ size and homeostasis by regulating cell proliferation, differentiation, apoptosis. abuse of aminoglycosides is one the main causes sensorineural hearing loss (SSNHL). However, role Hippo/YAP in cochlear hair (HC) damage protection auditory field still unclear. In this study, we used YAP agonist XMU-MP-1 (XMU) inhibitor Verteporfin (VP) regulate vitro. We showed that overexpression...
Ginseng has long been used in Asian countries for more than 2000 years. Currently, the "Western World or Western Medicines", many reports have indicated that they herbal medicines, and ginseng is one of most popular herbs. Several recent antioxidant/antioxidative stress activities play a role benefits ginseng; however, precise mechanism lacking. The antioxidant response element (ARE) critical regulatory expression enzymes phase II/III drug metabolizing/transporter genes, mediated by...
β-Lactams are commonly used for nosocomial infections and resistance to these agents among Gram-negative bacteria is increasing rapidly. Optimized dosing expected reduce the likelihood of development during antimicrobial therapy, but target clinical dose adjustment not well established. We examined that various exposures would suppress in an vitro hollow-fibre infection model.Two strains Klebsiella pneumoniae two Pseudomonas aeruginosa (baseline inocula ∼10 8 cfu/mL) were examined. Various...
Development of proper skin wound dressing is a vital step for repair, especially those patients with serious injuries. Herein, zinc-doped bioactive glass (ZBG)/succinyl chitosan (SCS)/oxidized alginate (OAL) composite hydrogels (Gel-ZBG) have been developed as dressings to accelerate closure. Schiff-based linkages introduced into the hydrogels, which provide humid microenvironment proliferation cells on sites. The amino groups from SCS and Zn2+ released ZBG exhibited excellent antibacterial...
Aminoglycoside-induced hair cell (HC) loss is one of the most important causes hearing loss. After entering inner ear, aminoglycosides induce production high levels reactive oxygen species (ROS) that subsequently activate apoptosis in HCs. Citicoline, a nucleoside derivative, plays therapeutic role central nervous system injury and neurodegenerative disease models, including addictive disorders, stroke, head trauma, cognitive impairment elderly, has been widely used clinic as an FDA approved...
The development of 20(<i>S</i>)-ginsenoside Rh2 (Rh2s) as a chemoprevention agent is limited by its low oral bioavailability. goals this study were to determine the mechanisms responsible for poor absorption and improve bioavailability overcoming barrier absorption. Comprehensive studies conducted using following models: 1) monolayers Caco-2, parental, multidrug resistance gene (MDR1)-overexpressing Madin-Darby canine kidney II (MDCKII) cells; 2) pharmacokinetics in wild-type (WT) FVB,...
It was recently proposed that the improved oral bioavailability of genistein aglycone and conjugates in Bcrp1(−/−) mice is mainly due to increased intestinal absorption subsequent elevated exposure conjugation enzymes. Here we tested this mechanism found did not increase compared with wild-type using an situ mouse perfusion model inhibition breast cancer resistance protein (BCRP) Caco-2 cells also significantly permeability or intracellular concentration aglycone. Separately, showed 5-...
ABSTRACT Cryptosporidium parasites are a major cause of diarrhea and malnutrition in the developing world, frequent waterborne disease developed potential bioterrorism agent. Currently, available treatment is limited, drug discovery remains largely unsuccessful. As result, pharmacokinetic properties required for vivo efficacy have not been established. We engaged program targeting IMP dehydrogenase ( Cp IMPDH). Here, we report activity eight potent selective inhibitors IMPDH interleukin-12...
Ginsenosides are hydrolyzed extensively by gut microflora after oral administration, and their metabolites pharmacologically active against lung cancer cells. In this study, we measured the metabolism of various ginsenosides determined mechanisms responsible for observed pharmacokinetic behaviors its metabolite, Compound K (C-K). The results showed that biotransformation into C-K is major metabolic pathway administration red ginseng extract containing both protopanaxadiol protopanaxatriol...
Several clinical studies have reported that hearing loss is correlated with autism in children. However, little known about the underlying mechanism between and autism. p21-activated kinases (PAKs) are a family of serine/threonine can be activated by multiple signaling molecules, particularly Rho small GTPases. Previous shown Pak1 mutations associated In present study, we take advantage knockout (Pak1−/−) mice to investigate role PAK1 function. We find highly expressed postnatal mouse...
Mechanochemistry refers to chemical reactions induced by mechanical forces. Due different reaction mechanisms, products obtained through mechanochemistry can be distinct from those produced thermochemistry and photochemistry. Scanning probe microscopy is a powerful tool for studying single-molecule mechanochemical processes. Mechanical force vector that has both magnitude direction. Previous studies have focused on triggering forces measuring their magnitude. In this work, we use the...