A5055121053- Advancements in Transdermal Drug Delivery
- Wound Healing and Treatments
- Cancer and Skin Lesions
- Advanced Drug Delivery Systems
- Hair Growth and Disorders
- Cancer-related molecular mechanisms research
- Bee Products Chemical Analysis
- Blood Coagulation and Thrombosis Mechanisms
- Electrospun Nanofibers in Biomedical Applications
- Reconstructive Surgery and Microvascular Techniques
- Pigment Synthesis and Properties
- 14-3-3 protein interactions
- Organ and Tissue Transplantation Research
- Genetic and rare skin diseases.
- Acute Ischemic Stroke Management
- TiO2 Photocatalysis and Solar Cells
- Venomous Animal Envenomation and Studies
- Transplantation: Methods and Outcomes
- Caveolin-1 and cellular processes
- Diabetes Management and Research
- Microencapsulation and Drying Processes
- Heparin-Induced Thrombocytopenia and Thrombosis
- Skin and Cellular Biology Research
- Diabetic Foot Ulcer Assessment and Management
- Pressure Ulcer Prevention and Management
Guangxi Academy of Sciences
2020-2021
First Affiliated Hospital of GuangXi Medical University
2018-2021
Guangxi Medical University
2018-2021
Anhui Agricultural University
2019-2020
Zhejiang Sci-Tech University
2018-2020
A self-responsive insulin delivery system is highly desirable because of its high sensitivity dependent on blood glucose levels. Herein, a smart pH-triggered and glucose-mediated transdermal system, insulin-loaded ZnO quantum dots (ZnO QDs) capped mesoporous bioactive glasses (MBGs) integrated with microneedles (MNs), was developed to achieve control painless administration. QDs as promise pH-responsive switch were employed cap the nanopores MBGs via electrostatic interaction. The drug...
Near-infrared (NIR) light-triggered and separable segmented microneedles (MNs), consisting of lauric acid polycaprolactone (LA/PCL) arrowheads poly(vinyl alcohol) (PVA/PVP) supporting bases, have been fabricated. A hypoglycemic drug (metformin) photothermal conversion factor (Cu7S4 nanoparticles) are encapsulated into LA/PCL arrowheads. Due to the dissolution soluble bases after absorption tissue fluid, MNs can be embedded skin insertion. Under NIR-light irradiation, exhibit an excellent...
Development of proper skin wound dressing is a vital step for repair, especially those patients with serious injuries. Herein, zinc-doped bioactive glass (ZBG)/succinyl chitosan (SCS)/oxidized alginate (OAL) composite hydrogels (Gel-ZBG) have been developed as dressings to accelerate closure. Schiff-based linkages introduced into the hydrogels, which provide humid microenvironment proliferation cells on sites. The amino groups from SCS and Zn2+ released ZBG exhibited excellent antibacterial...
Herein, an NIR-responsive polymeric microneedle (MN) system incorporated with metformin-loaded and polydopamine/lauric-acid-coated (PDA/LA-coated) hollow mesoporous SiO2 has been developed for transdermal delivery of antidiabetic drug (metformin). First, was loaded within nanoparticles (HMSNs) by a diffusion method. Then, PDA as photothermal conversion agent lauric acid (LA) phase change material (PCM) were coated onto the HMSN to form nanocarriers. Finally, these PDA/LA-coated HMSNs...
A novel cellulose/TiO 2 / β -CD hydrogel with high photocatalytic antibacterial activity and sustained release of drug was prepared. TiO sol a diameter about 9 nm in this the photoantibacterial agent. can significantly enhance sustained-release effect hydrogel. The structure property composite were characterized by Fourier transform infrared spectroscopy (FTIR), X-ray diffraction (XRD), scanning electron microscopy (SEM), transmission (TEM). Escherichia coli Staphylococcus aureus selected as...
Wound dressing has been used for decades to be effective accelerating skin wound healing. However, practical applications are still limited due their lower cell affinity, tissue adhesiveness, and biocompatibility. Natural polymers the important biomaterials because of excellent biodegradability, biocompatibility, low immunogenicity. In this work, composite bioadhesives (PLS-CS/RSF) were prepared from regenerated silk fibroin (RSF) polylysine-modified chitosan (PLS-CS) that cross-linked by...
The traditional subcutaneous or intravenous injection of insulin can not effectively control the release insulin, resulting in an unregulated blood glucose levels on diabetic patients. It is urgently to develop a self-controllable delivery system with high sensitivity change vivo. In this work, polymer microneedles (MNs) integrated glucose-responsive mesoporous bioactive glass nanoparticles (BGNs) for transdermal had been developed self-regulate and painless administration. hypoglycaemic...
Abstract It is well known that dermal papilla cells (DPCs) are crucial for hair follicle growth and regeneration. However, in 2D culture could lose their ability of regeneration after several passage intervals. As opposed to DPCs culture, the 3D extensively. molecular mechanisms DPCs’ remain unclear. Accordingly, gene sequencing recommended investigation between three groups were established including 2 8 culture. The differentially expressed genes (DEGs) identified using Venn diagram these...
To investigate whether hirudin exerts its antithrombin action to decrease the ratio of Human Microvascular Endothelial Cells (HMVECs) apoptosis.Human microvascular endothelial cells cultured in third and fifth generations were used. HMVECs divided into normal group, thrombin group (T group), natrual (H + H AG490 natural group).Apart from other groups exposed relevant drugs for 24 hours.HMVEC apoptosis was assessed by flow cytometric double Immunofluorescence phosphorylation JAK (P-JAK2)...
Adult stem cell function has been one of the most intensively explored areas biological and biomedical research, with hair follicle cells serving as best model systems. This study role transcription factor DLX5 in regulating (HFSC) differentiation.HFSCs were isolated, characterized, assessed for their expression DLX5, c-MYC, NSD1, miR-29c-3p using RT-qPCR, Western blot analysis, or immunofluorescence. Next, ability HFSCs to proliferate well differentiate into either sebaceous gland epidermal...
Objective To explore the effect of natural hirudin on proliferation human microvascular endothelial cells (HMVECs) and its preliminary mechanism promoting angiogenesis. Methods Three-dimensional culture models HMVECs were established in vitro observed by inverted phase contrast microscopy after 24 hours culturing. Then, three-dimensional treated with different concentrations (1, 4, 7 ATU/mL) hirudin, respectively, Dulbecco's modified Eagle's medium containing 10% fetal bovine serum as...
Objective To study the effect of hirudin on perfusion and angiogenesis in distal ischemic skin flap. Methods The 35 SD rats, two random dorsal flaps were made individual rat assigned randomly into group control group. Hirudin was injected with 0.5 U same amount saline. The flap tissue perfusion, microvessel density (MVD) biopsies expression vascular endothelial growth factor (VEGF) thrombospondin-1 (TSP-1) detected by a full-field laser imager, immunohistochemistry Western blot,...
Objective To explore the effect of hyperbaric oxygen preconditioning with different frequency on survival rate flap and ischemia-reperfusion injury in rats after transplantation, to best conditions improve rat flaps transplantation. Methods Thirty-six Sprague Dawley were randomly divided into four groups according random number table method, 9 each group.Four pretreated pretreatment for 0, 2, 4, 6 days before operation, control group, 2 d 4 group. Taking midline back as axis, an...