A glucose-mediated insulin delivery system would be highly satisfactory for diabetes diagnosis dependent on the concentration of blood glucose in body. Herein, a novel microneedle (MN) device integrated with insulin-loaded and H2O2-responsive mesoporous silica nanoparticles (MSNs) was designed to achieve fast painless administration. The MSNs were obtained by modification 4-(imidazoyl carbamate)phenylboronic acid pinacol ester (ICBE) following host-guest complexation between ICBE...

Biofilms are chief culprits of most intractable infections and pose great threats to human health. Conventional antibiotic therapies hypodynamic biofilms due their strong drug resistance, closely related with biofilm hypoxia. A new strategy for enhanced therapy by relieving hypoxia is reported here. two-step sequential delivery fabricated using perfluorohexane (PFH)-loaded liposomes (lip) as oxygen (O2) carriers (denoted lip@PFH@O2) commercial antibiotics. The results indicate that the...

Electrospun carbon nanofiber composites (ZnCo₂O₄/Ag–GO–CNFs) coated with 3D urchin-like ZnCo₂O₄ nanosheets have been prepared and exhibit excellent specific capacity cycling stability.

Chemodynamic therapy (CDT) has emerged as a promising strategy for cancer treatment. However, its effectiveness been hindered by insufficient hydrogen peroxide (H2O2) and high reductive glutathione (GSH) within tumors, which are the two main reasons inefficiency of Fenton/Fenton-like reaction-based CDT. Herein, we present H2O2 boost-GSH depletion enhanced CDT to fight against melanoma through microneedle (MN)-based transcutaneous delivery method. The MN system is composed dissolvable...

Near-infrared light triggered and separable microneedles (MNs) were fabricated by a unique molding method. The photothermal conversion agent (Prussian blue nanoparticles, PB NPs) hypoglycemic drug (metformin) embedded into the polycaprolactone (PCL) MNs arrowheads. These arrowheads capped on dissolving polyvinyl alcohol/polyvinyl pyrrolidone (PVA/PVP) solid supporting substrate. as-fabricated exhibited excellent properties under near-infrared (NIR) irradiation, causing to melt due of NPs....

A self-responsive insulin delivery system is highly desirable because of its high sensitivity dependent on blood glucose levels. Herein, a smart pH-triggered and glucose-mediated transdermal system, insulin-loaded ZnO quantum dots (ZnO QDs) capped mesoporous bioactive glasses (MBGs) integrated with microneedles (MNs), was developed to achieve control painless administration. QDs as promise pH-responsive switch were employed cap the nanopores MBGs via electrostatic interaction. The drug...

Near-infrared (NIR) light-triggered and separable segmented microneedles (MNs), consisting of lauric acid polycaprolactone (LA/PCL) arrowheads poly(vinyl alcohol) (PVA/PVP) supporting bases, have been fabricated. A hypoglycemic drug (metformin) photothermal conversion factor (Cu7S4 nanoparticles) are encapsulated into LA/PCL arrowheads. Due to the dissolution soluble bases after absorption tissue fluid, MNs can be embedded skin insertion. Under NIR-light irradiation, exhibit an excellent...

Medical catheters are prone to fouling by protein adsorption and platelet adhesion/activation due their hydrophobic surface, resulting in bacterial adhesion/biofilm formation, associated infection, thrombosis. Hence, an ultralow-fouling exceptional infection-resistant coating on devices is urgently needed. Herein, we synthesized mussel-inspired cationic polypeptide (cPep) mixed-charge (mPep) via N-carboxyanhydride ring opening polymerization method. In the view of chemical structure,...

To achieve high sensitivity for 19F MRI, a class of novel dendritic molecules with multiple pseudosymmetrical fluorines was designed and efficiently synthesized. Through iterative bromination Williamson ether synthesis under mild conditions, fluorinated dendrimer 540 conveniently prepared without performing the group protection in convergent way. The is characterized by strong NMR peak short relaxation times. Eventually, an appreciably enhanced MRI at extremely low concentration (18.5 μM)...

Crystalline/ionic liquid crystalline block copolymers (BCPs) with various compositions have been successfully prepared by sequential reactions. The effect of corona order on self-assembly BCPs in selective solvent is investigated detail. It found that two-dimensional single crystals well-developed shapes are formed when the present. By contrast, ill-developed platelets small size or one-dimensional worm-like micelles assembled if segments lost. speculated preferred parallel arrangement...

An efficient photodynamic antibacterial spray-coating is developed with a very low MB density and high singlet oxygen quantum yield.

Infected wound healing is a complex and dynamic process affecting millions of people. Since contains multiple stages, it requires staged management to realize the early inhibition infection subsequent promotion healing. A key point design biphasic release system with antibacterial agents growth factors promote regeneration. As safe, efficient painless transdermal drug delivery method, microneedles (MNs) have attracted widespread attention. Herein, we present dissolving MNs an agent factor...

Regulating the behavior of different types cells at material–tissue interface is pivotal for inducing tissue regeneration. Traditional methods enhance target cell activity using specific ligands such as peptides and antibodies, which have stability issues within biological environments. Herein, we show that selective resistance can be realized by fine-tuning material surface chemistry, achieving strong selectivity superior to extracellular matrix peptides. A certain degree adsorption...

Both (19)F MRI and optical imaging are powerful noninvasive molecular modalities in biomedical applications. To integrate these two complementary modalities, the design synthesis of a novel MRI/fluorescence dual-modal agent is reported herein. Through Sonogashira coupling reaction between fluorinated phenylacetylene 1,2,4,5-tetraiodobenzene, fluorophore with 48 symmetrical fluorines at its periphery was constructed high efficacy. High aqueous solubility achieved by PEGylation monodisperse...

This study described near-infrared (NIR) light-responsive polymer-nanodot composite microneedles (MNs) used for on-demand transdermal drug delivery. Bismuth (Bi) nanodots stabilized by poly(vinylpyrrolidone) (PVP) as a photothermal conversion agent and metformin an antidiabetic were introduced into the dissolving MNs coated with lauric acid (LA). When irradiated NIR light, light-to-heat transduction induced Bi caused LA to melt. As result, polymer matrix was dissolved after absorbing...