A5100680636- Pancreatic and Hepatic Oncology Research
- Cancer, Hypoxia, and Metabolism
- Advanced Drug Delivery Systems
- Cancer Research and Treatments
- Advancements in Transdermal Drug Delivery
- Advanced biosensing and bioanalysis techniques
- RNA modifications and cancer
- Mitochondrial Function and Pathology
- Drug Solubulity and Delivery Systems
- Ginseng Biological Effects and Applications
- Nanoplatforms for cancer theranostics
- Pharmacological Effects of Natural Compounds
- DNA and Nucleic Acid Chemistry
- Metabolism and Genetic Disorders
- Traditional Chinese Medicine Analysis
- Molecular Junctions and Nanostructures
- Coenzyme Q10 studies and effects
- Machine Learning in Bioinformatics
- Phytochemistry and Biological Activities
- Berberine and alkaloids research
- Microbial Metabolic Engineering and Bioproduction
- Immune cells in cancer
- Cancer-related molecular mechanisms research
- Silk-based biomaterials and applications
- Protein Tyrosine Phosphatases
Ministry of Education of the People's Republic of China
2017-2025
The University of Adelaide
2025
Anhui University of Traditional Chinese Medicine
2015-2024
China Medical University
2020-2024
Northwest A&F University
2024
Shanghai Institute of Technology
2023-2024
South Australia Pathology
2022-2023
Innovation Team (China)
2023
China Agricultural University
2023
Shenyang Agricultural University
2023
Critically ill infants and children with rare diseases need equitable access to rapid accurate diagnosis direct clinical management. Over 2 years, the Acute Care Genomics program provided whole-genome sequencing 290 families whose critically were admitted hospitals throughout Australia suspected genetic conditions. The average time result was 2.9 d diagnostic yield 47%. We performed additional bioinformatic analyses transcriptome in all patients who remained undiagnosed. Long-read functional...
The self-assembly of bis-biotinylated double-stranded DNA and the tetravalent biotin-binding protein strepta-vidin (STV) have been studied by non-denaturing gel electrophoresis atomic force microscopy (AFM). rapid reproducibly generated populations individual oligomeric complexes. Most strikingly, oligomers predominantly contained bivalent STV molecules bridging two adjacent fragments to form linear nanostructures. Trivalent branch points occurred with a lower frequency presence was scarce....
Huperzine A (Hup-A) is a poorly water-soluble drug with low oral bioavailability. self-microemulsifying delivery system (SMEDDS) was used to enhance the bioavailability and lymphatic uptake transport of Hup-A. single-pass intestinal perfusion (SPIP) technique chylomicron flow-blocking approach were study its absorption, mesenteric lymph node distribution uptake. The value area under plasma concentration-time curve (AUC) Hup-A SMEDDS significantly higher than that suspension (P<0.01)....
It is extremely important to develop a minimally invasive and efficient approach for treatment of superficial skin tumors (SSTs). In this work, near-infrared (NIR)-triggered transdermal therapeutic system based on two-stage separable microneedles (MNs) has been proposed synergistic chemo-photothermal therapy against SSTs. Lauric acid polycaprolactone as phase-change materials have used prepare the arrowheads MNs in which an anticancer drug (doxorubicin, DOX) photothermal agent (indocyanine...
Herein, an NIR-responsive polymeric microneedle (MN) system incorporated with metformin-loaded and polydopamine/lauric-acid-coated (PDA/LA-coated) hollow mesoporous SiO2 has been developed for transdermal delivery of antidiabetic drug (metformin). First, was loaded within nanoparticles (HMSNs) by a diffusion method. Then, PDA as photothermal conversion agent lauric acid (LA) phase change material (PCM) were coated onto the HMSN to form nanocarriers. Finally, these PDA/LA-coated HMSNs...
The development of multifunctional nanoformulations (NFs) include several features in a single nanosystem for these devices to overcome the disadvantages inefficiency and undesirable toxicity traditional therapies provide new opportunities management tumors. Herein, CaO2@Mn-PDA NFs with core-shell structure, integrating photothermal conversion properties Mn-PDA, chemodynamic doped Mn ions, relieving hypoxia tumor microenvironment (TME) were developed. as-fabricated embedded microneedles...
Drug resistance has emerged as a great challenge for achieving satisfactory therapeutic efficacy in platinum-based chemotherapy. Specifically, we synthesized series of host defense peptide mimics with different degrees polymerization (DP), i.e., poly(ethylene glycol)-poly(2-azepane ethyl methacrylate) (PEG45-PAEMAn, n = 8, 20, 43, 87, and 183), which displayed DP- pH-dependent plasma membrane-disruptive capability antitumor activity. Among these, PEG45-PAEMA43 exhibited the highest...
Quantifying the biodistribution of lipid nanoparticles (LNPs) is critical for optimizing mRNA delivery systems, yet current approaches have inherent limitations. This study introduces a cost-effective method utilizing double-stranded DNA (dsDNA) barcodes and quantitative polymerase chain reaction (qPCR) rapid analysis small library mRNA-LNPs functional in vivo. Three unique 100-bp dsDNA were designed to represent three FDA-approved LNP formulations. Concurrently, these formulations carrying...
Thermal denaturation and subsequent rapid cooling allow novel supramolecular DNA nanocircles to be obtained in high yields from oligomeric conjugates consisting of bisbiotinylated streptavidin (see scanning force microscopy image on the left). The endogenous protein molecule within (picture right) can conveniently used for further functionalization.
The traditional subcutaneous or intravenous injection of insulin can not effectively control the release insulin, resulting in an unregulated blood glucose levels on diabetic patients. It is urgently to develop a self-controllable delivery system with high sensitivity change vivo. In this work, polymer microneedles (MNs) integrated glucose-responsive mesoporous bioactive glass nanoparticles (BGNs) for transdermal had been developed self-regulate and painless administration. hypoglycaemic...