In this paper, berberine hydrochloride-loaded liposomes-in-gel were designed and developed to investigate their antioxidant properties therapeutic effects on the eczema model of mouse. Berberine hydrochloride-liposomes (BBH-L) as nanoparticles prepared by thin-film hydration method then dispersed BBH-L evenly in gel matrix prepare hydrochloride liposomes-gel (BBH-L-Gel) natural swelling method. Their capacity was investigated free radical scavenging ability 2,2-diphenyl-1-picrylhydrazyl...

Kaempferol liposome hydrogel is a novel drug carrier designed to solve the problems of poor water solubility and low bioavailability kaempferol. By combining kaempferol with liposomes further forming hydrogel, this composite formulation not only improves stability but also enhances its penetration therapeutic effect on skin. It was demonstrated that liposomal had ex vivo in antioxidant activities, which could effectively inhibit inflammatory response oxidative stress and, thus, showed...

Tetramethylpyrazine (TMP) has low bioavailability due to its fast metabolism and short half-life, which is not conducive transdermal treatment of atopic dermatitis (AD). Therefore, in this study, TMP was encapsulated into liposomes (Lip) by film dispersion method, then the surface Lip modified sodium alginate (ALG) chitosan (CS). The tetramethylpyrazine-loaded hydrogel called T-Lip-AC hydrogel. In vitro experiments, we found that only antibacterial effect CS, but also enhances...

The purpose of this study was to prepare and evaluate kaempferol-loaded carbopol polymer (acrylic acid) hydrogel, investigate its antioxidant activity in vitro, compare the effects on drug release under different pH conditions. Drug studies were conducted three media (pH 3.4, 5.4, 7.4). hydrogel prepared by using 934 as matrix. morphology viscosity preparation tested understand fluidity hydrogel. studied scavenging hydrogen peroxide 2,2-diphenyl-1-picrilhidrazil (DPPH) radicals vitro...

Long-term sunlight exposure will cause the accumulation of free radicals in skin and lead to oxidative damage aging, antioxidant drugs have gradually become focus research, but there is little research on for percutaneous treatment. The purpose this study was prepare ligustrazine hydrochloride (TMPZ)-loaded liposome–hydrogel (TMPZ-LG), evaluate its properties, apply it mice observe whether had preventive therapeutic effect irradiation under ultraviolet rays, an attempt make into a new kind...

Psoriasis is a chronic skin disease caused by the interaction of multiple factors that leads to abnormal growth stratum corneum cells and has been called an immortal cancer. Docetaxel trialed for treatment psoriasis due its superior ability induce apoptosis, but insolubility low bioavailability have hampered development. Here, docetaxel (DTX)-loaded liposomes-in-gel (DTX-LP-G) as transdermal delivery was investigated via modulating IL6-HIF-1α-VEGF axis. The results demonstrated DTX-LP-G...

Abstract Graft copolymerization of maleic anhydride (MA) onto poly(3‐hydroxybutyrate) (PHB) was carried out by use benzoyl peroxide as initiator. The effects various polymerization conditions on graft degree were investigated, including solvents, monomer and initiator concentrations, reaction temperature, time. concentrations played an important role in copolymerization, could be controlled the range from 0.2 to 0.85% changing conditions. crystallization behavior thermal stability PHB...

Abstract: Aim: Berberine hydrochloride is a Traditional Chinese Medicine component with antibacterial, antiviral, anti-inflammatory, antioxidant and lowering blood sugar effects. However, the application of berberine has been hindered for long time due to its poor solubility low bioavailability. This study aims design liposomes-gel enhance bioavailability activity hydrochloride. Materials Methods: The thin-film dispersion hydration method was used prepare liposomes, prepared by natural...

Paeonol (PAE) is a hydrophobic drug. In this study, we encapsulated paeonol in lipid bilayer of liposomes (PAE-L), which delayed drug release and increased solubility. When PAE-L was dispersed gels (PAE-L-G) based on poloxamer matrix material for local transdermal delivery, observed amphiphilicity, reversible thermal responsiveness, micellar self-assembly behavior. These can be used atopic dermatitis (AD), an inflammatory skin disease, to change the surface temperature skin. prepared PAE-L-G...

Cutaneous eczema is a kind of skin disease characterized by inflammation. The main manifestations are various types dermatitis, eczema, and urticaria. There usually complications such as erythema, blisters, epidermal peeling. quercetin might have therapeutic effect on cutaneous due to its favorable antioxidant activity anti-inflammatory effects. Currently, there few studies transdermal administration drugs for the treatment eczema. aim this study was prepare quercetin-containing...

Extracellular vesicles (EVs) are nanoscale luminal that participate in the information transfer of proteins, nucleic acids, and lipids between cells, thereby playing a role treatment diseases delivery nutrients. In recent years, plant-derived EVs (PDEVs) containing bioactive compounds have attracted increasing interest due to their better biocompatibility lower cytotoxicity healthy tissues. biomedical field, PDEVs been used as cargo carriers achieve various functions through engineering...

Medium additives have been shown to affect the synthesis of active products in fungi. This study investigated effects corn stalk, poplar sawdust, Tween-80, and oleic acid on mycelial biomass physicochemical properties, as well bioactivity polysaccharides, including exopolysaccharides (EPS) intracellular polysaccharides (IPS), submerged culture Bjerkandera fumosa. Results showed that addition stalk or sawdust increased production EPS but decreased IPS; Tween-80 had less effect stimulated...

Sinomenine hydrochloride is an excellent drug with anti-inflammatory, antioxidant, immune-regulatory, and other functions. Atopic dermatitis inherited allergic inflammation that causes itchiness, redness, swelling in the affected area, which can have a significant impact on life of patient. There are many therapeutic methods for atopic dermatitis, sinomenine immunomodulatory activity might be effective treatment dermatitis. In this study, model was established experimental mice, physical...

An extracellular poly (β-hydroxybutyrate) (PHB) depolymerase was purified from Penicillium sp. DS9701-D2. The molecular weight of the enzyme estimated to be about 46.8 KDa by sodium dodecyl sulfate—polyacrylamide gel electrophoresis. isoelectric point 7.6 for determined capillary optimum activity detected at 30°C and pH 5.0. It found that Na+ K+ enhance activity, whereas Zn2+, Mg2+, Cu2+, Fe2+ inhibit it. secondary structure measured circular dichroism (CD) spectroscopy. main degradation...

When the skin is overexposed to ultraviolet rays, free radicals will accumulate in skin, causing lipid damage and even inducing photoaging of skin. Combination therapy with antioxidant drugs a good choice for topical treatment due its special physiological structure. In this paper, shikonin was encapsulated β-cyclodextrin (SH-β-CD) by precipitation crystallization method, which delayed release drug increased solubility. The average diameter SH-β-CD 203.0 ± 21.27 nm zeta potential -14.4 0.5...

Shikonin has anticancer activity, but it not yet been applied into clinical use. In the present study, shikonin was prepared using liposomes. We aimed to examine several aspects of sh-L (shikonin-containing liposomes): preparation, angiogenic suppression and cellular uptake through self-fluorescence. Sh-L were soybean phospholipid cholesterol form membrane encapsulated membrane. Three liposomes with shikonin. They had red fluorescence analysed a flow cytometer. Angiogenic determined MTT...