A5051583298- Genomics, phytochemicals, and oxidative stress
- Photodynamic Therapy Research Studies
- Nanoplatforms for cancer theranostics
- Glutathione Transferases and Polymorphisms
- Fatty Acid Research and Health
- Porphyrin and Phthalocyanine Chemistry
- Epigenetics and DNA Methylation
- Cancer Treatment and Pharmacology
- Cancer, Hypoxia, and Metabolism
- Pharmacological Effects of Natural Compounds
- Phytochemicals and Antioxidant Activities
- Curcumin's Biomedical Applications
- Ginseng Biological Effects and Applications
- Free Radicals and Antioxidants
- Vitamin C and Antioxidants Research
- Histone Deacetylase Inhibitors Research
- Medicinal Plants and Bioactive Compounds
- Adipokines, Inflammation, and Metabolic Diseases
- Cancer Risks and Factors
- Cancer, Lipids, and Metabolism
- Bladder and Urothelial Cancer Treatments
- Eicosanoids and Hypertension Pharmacology
- Skin Protection and Aging
- Antioxidant Activity and Oxidative Stress
- Plant-derived Lignans Synthesis and Bioactivity
Rutgers, The State University of New Jersey
2009-2018
Rutgers Sexual and Reproductive Health and Rights
2016
Rütgers (Germany)
2016
National Cancer Centre Singapore
2012
Weatherford College
2011
National University of Singapore
2005-2008
The purpose of this study was to compare the hepatic and small intestinal metabolism, examine bioavailability gastro-intestinal first-pass effects, kaempferol in rats. Liver microsomes fortified with either NADPH or UDPGA were incubated varying concentrations for up 120 min. Based on values kinetic constants (K(m) V(max)), propensity UDPGA-dependent conjugation compared NADPH-dependent oxidative metabolism higher both microsomes. Male Sprague-Dawley rats administered intravenously (i.v.)...
Ultraviolet (UV) of sunlight is a complete carcinogen that can burn skin, enhance inflammation, and drive skin carcinogenesis. Previously, we have shown sulforaphane (SFN) inhibited chemically induced carcinogenesis via nuclear factor (erythroid-derived 2)-like 2 (Nrf2) others broccoli sprout extracts containing high SFN protected against UV-induced in SKH-1 hairless mice. A recent study showed there was no difference between Nrf2 knockout (Nrf2 KO) wild-type (WT) BALB/C mice after exposing...
Abstract Apigenin (API) and luteolin (LUT) have been used as therapeutic agents in folk medicine for thousands of years. These compounds exert a variety biological activities, including anticancer, antioxidant antiinflammatory activities. This study investigated whether API LUT could activate Nrf2‐antioxidant response element (ARE)‐mediated gene expression induce activities human hepatoma HepG2 cells. The did not exhibit any substantial toxicity at low doses (1.56–6.25 µ m ). induction ARE...
The role of phytochemicals in preventive and therapeutic medicine is a major area scientific research. Several studies have illustrated the mechanistic roles Nrf2 transcriptional activation. present study aims to examine importance transcription factor by treating peritoneal macrophages from Nrf2(+/+) Nrf2(-/-) mice ex vivo with phenethyl isothiocyanate (PEITC) curcumin (CUR). were pretreated drugs challenged lipopolysaccharides (LPSs) alone combination PEITC or CUR assess their...
Cancer development has been linked to epigenetic modifications of cancer oncogenes and tumor suppressor genes; in advanced metastatic cancers, severe are present. We previously demonstrated that the progression prostate tumors TRAMP mice is associated with methylation silencing Nrf2 promoter a reduced level transcription target genes. Radix Angelicae Sinensis (RAS; Danggui) medicinal herb health food supplement widely used Asia for centuries. Z-Ligustilide (Lig) one bioactive components RAS....
The antioxidant response element (ARE) is a critical regulatory for the expression of many phase II drug metabolizing enzymes (DME), III transporters and enzymes, mediated by transcription factor Nrf2. aim this study was to examine potential activation synergism Nrf2-ARE-mediated transcriptional activity between four common phytochemicals present in cruciferous vegetables; indoles: indole-3-carbinol (I3C), 3,3′-diindolylmethane (DIM); isothiocyanates (ITCs): phenethyl isothiocyanate (PEITC)...
This study is to investigate the role of Nrf2 in suppressing LPS-mediated inflammation ex vivo macrophages by polyunsaturated fatty acids (PUFA) docosahexaenoic acid (DHA) and eicosapentaenoic (EPA). Primary peritoneal from wild-type (+/+; WT) knockout (-/-; KO) mice were treated with lipopolysaccharides (LPS) presence or absence DHA EPA. Quantitative real-time PCR (qPCR) analyses showed that LPS potently induced cyclooxygenase-2 (COX-2), inducible nitric oxide synthase (iNOS), interleukin-1...
Ginseng has long been used in Asian countries for more than 2000 years. Currently, the "Western World or Western Medicines", many reports have indicated that they herbal medicines, and ginseng is one of most popular herbs. Several recent antioxidant/antioxidative stress activities play a role benefits ginseng; however, precise mechanism lacking. The antioxidant response element (ARE) critical regulatory expression enzymes phase II/III drug metabolizing/transporter genes, mediated by...
Nrf2 plays a critical role in defending against oxidative stress and inflammation. We previously reported that confers protection ultraviolet-B (UVB)-induced inflammation, sunburn reaction, is involved sulforaphane-mediated photo-protective effects the skin. In this study, we aimed to demonstrate protective of inflammation-mediated extracellular matrix (ECM) damage induced by UVB irradiation. Ear biopsy weights were significantly increased both wild-type (Nrf2 WT) knockout KO) mice one week...
Abstract Background Eight medicinal plants were tested for their antimicrobial and antioxidant activities. Different extraction methods also effects on the bioactivities of plants. Methods plants, namely Herba Polygonis Hydropiperis ( Laliaocao ), Folium Murraya Koenigii Jialiye Rhizoma Arachis Hypogea Huashenggen Houttuyniae Yuxingcao Epipremnum pinnatum Pashulong Typhonium Flagelliforme Laoshuyu Cortex Magnoliae Officinalis Houpo ) Imperatae Baimaogen investigated potential properties....
Previous clinical and epidemiological studies of vitamin E have used primarily α-tocopherol for the prevention cancer. However, γ-tocopherol has demonstrated greater anti-inflammatory anti-tumor activity than in several animal models This study assessed potential chemopreventive activities a tocopherol mixture containing 58% (γ-TmT) an established rodent model mammary carcinogenesis. Female ACI rats were utilized due to their sensitivity 17β-estradiol (E2 ) induce hyperplasia neoplasia. The...
ABSTRACT The root of Angelica sinensis (Oliv.) Diels (abbreviated as AS) (Danggui) has a long history in Asian herbal medicine. Recently, it was demonstrated that AS possesses anti‐cancer and anti‐oxidant activities. Because the transcription factor Nrf2 mediates expression many cellular anti‐oxidative stress genes, including genes are involved phase II drug metabolism stress, this study sought to investigate whether pure compounds from or an extract could activate antioxidant response...
Abstract Indole‐3‐carbinol (I3C) found abundantly in crucifers has been shown to possess anti‐cancer effects. The present study aims examine the chemopreventive effects and molecular mechanism of I3C, particularly anti‐oxidative stress pathway regulated by nuclear erythroid related factor 2 (Nrf2). HepG2‐C8‐ARE‐luciferase cells were used for Nrf2‐ARE activity. TRAMP C1 investigate I3C on Nrf2‐mediated genes. To test efficacy transgenic adenocarcinoma mouse prostate (TRAMP) mice fed with 1%...
This article reviews recent basic and clinical studies of ginseng, particularly the anti-cancer effects potential chemopreventive actions by activating transcriptional factor, nuclear factor (erythroid-derived 2)-like 2 (Nrf2 or NFE2L2)-mediated anti-oxidative stress anti-inflammatory pathways. Nrf2 is a novel target for cancer prevention as it regulates antioxidant responsive element (ARE), critical regulatory in promoter region genes encoding cellular phase II detoxifying enzymes. The on...