Melvilí Cintrón

ORCID: 0000-0003-2053-2541
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About
Contact & Profiles
Research Areas
  • Pneumonia and Respiratory Infections
  • Respiratory viral infections research
  • Antifungal resistance and susceptibility
  • Mycobacterium research and diagnosis
  • Fungal Infections and Studies
  • Tuberculosis Research and Epidemiology
  • Viral gastroenteritis research and epidemiology
  • Viral Infections and Outbreaks Research
  • Salmonella and Campylobacter epidemiology
  • Infectious Diseases and Mycology
  • Yersinia bacterium, plague, ectoparasites research
  • Clinical Nutrition and Gastroenterology
  • Pneumocystis jirovecii pneumonia detection and treatment
  • Aquaculture disease management and microbiota
  • Free Radicals and Antioxidants
  • Clinical Laboratory Practices and Quality Control
  • Cystic Fibrosis Research Advances
  • Pregnancy and Medication Impact
  • Vibrio bacteria research studies
  • Bacterial Infections and Vaccines
  • Infectious Diseases and Tuberculosis
  • COVID-19 and healthcare impacts
  • Interstitial Lung Diseases and Idiopathic Pulmonary Fibrosis
  • Phytochemicals and Antioxidant Activities
  • Neutropenia and Cancer Infections

Memorial Sloan Kettering Cancer Center
2019-2025

Johnson University
2019

Rutgers, The State University of New Jersey
2011-2019

University of Puerto Rico-Mayaguez
2011

The antioxidant response element (ARE) is a critical regulatory for the expression of many phase II drug metabolizing enzymes (DME), III transporters and enzymes, mediated by transcription factor Nrf2. aim this study was to examine potential activation synergism Nrf2-ARE-mediated transcriptional activity between four common phytochemicals present in cruciferous vegetables; indoles: indole-3-carbinol (I3C), 3,3′-diindolylmethane (DIM); isothiocyanates (ITCs): phenethyl isothiocyanate (PEITC)...

10.1002/bdd.759 article EN Biopharmaceutics & Drug Disposition 2011-06-08

Abstract Background Cancer patients have a 2.4-fold higher risk of dying from pneumonia compared to the general population. Streptococcus pneumoniae is one most common etiologies community-acquired pneumonia. Serotype specific information nonbacteremic pneumococcal in oncology settings limited. Thus, we described frequency S. serotypes detected by serotype-specific urinary antigen (SSUAD) assay cancer patients.Table 1.Clinical characteristics adult tested with SSUAD Methods This was an...

10.1093/ofid/ofae631.850 article EN cc-by Open Forum Infectious Diseases 2025-01-29

The Mycobacterium tuberculosis genome harbors an unusually high number of toxin-antitoxin (TA) systems. These TA systems have been implicated in establishing the nonreplicating persistent state this pathogen during latent infection. More than half M. belong to VapBC (virulence associated protein) family. In work, we first identified RNA targets for VapC-mt11 (VapC11, Rv1561) toxin vitro learn more about general function family toxins. Recombinant cleaved 15 45 tRNAs at a single site within...

10.1038/s41598-019-41548-9 article EN cc-by Scientific Reports 2019-04-11

Abstract Identification of pathogens with pulmonary presentation in patients hematologic malignancies may be challenging because diagnostic difficulty related to the underlying malignancy and limitations conventional microbiologic methods. Herein, we present a case series 3 consolidations due Legionella bozemanae necrotizing pneumonia, Pneumocystis jirovecii disseminated Scedosporium infection, who were diagnosed by microbial cell-free DNA next-generation sequencing. We observed that this...

10.1097/ipc.0000000000001101 article EN Infectious Diseases in Clinical Practice 2022-02-03

Initial workup [e.g., identification (ID) and/or antimicrobial susceptibility testing (AST)] of bacterial growth on solid media traditionally occurs 16-24 h after sub-culturing positive blood cultures (BC). Early ID and AST can be facilitated by reviewing digital images captured using a Microbiology Laboratory Automation (MLA) system. The goal this study was to evaluate the utility at 4 WASPLab MLA system for rapid AST. Retrospective review all BCs results between 1 January 2021 31 July 2022...

10.1128/jcm.01320-24 article EN cc-by Journal of Clinical Microbiology 2024-12-20

Abstract Background Cancer patients with pneumonia (PNA) have 2 to 21 times higher mortality rate compared the general population. The Pneumonia Severity Index (PSI) and CURB-65 scale been used predict for community acquired (CAP). While these scales are well studied in population, there is a paucity of research on utility PSI predicting outcomes from CAP cancer. In this study, we assessed relationship between score 30-day cancer at Memorial Sloan Kettering Center (MSKCC). Methods A...

10.1093/ofid/ofad500.2195 article EN cc-by Open Forum Infectious Diseases 2023-11-27
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