A5100661990- Cytomegalovirus and herpesvirus research
- Virus-based gene therapy research
- Polyomavirus and related diseases
- Herpesvirus Infections and Treatments
- Parvovirus B19 Infection Studies
- Mycobacterium research and diagnosis
- Antifungal resistance and susceptibility
- CAR-T cell therapy research
- Fungal Infections and Studies
- Cystic Fibrosis Research Advances
- Pneumocystis jirovecii pneumonia detection and treatment
- COVID-19 and healthcare impacts
- Bacterial Identification and Susceptibility Testing
- Hematopoietic Stem Cell Transplantation
- Thyroid Cancer Diagnosis and Treatment
- Nutrition, Health and Food Behavior
- Pneumonia and Respiratory Infections
- Gut microbiota and health
- Neutropenia and Cancer Infections
- COVID-19 Clinical Research Studies
- Transplantation: Methods and Outcomes
- Acute Myeloid Leukemia Research
- Viral-associated cancers and disorders
- Immune Cell Function and Interaction
- Nutrition and Health in Aging
Memorial Sloan Kettering Cancer Center
2016-2025
Cornell University
2015-2025
Seoul National University
2024
Seoul National University Bundang Hospital
2018-2024
Weill Cornell Medicine
2022-2024
Office of Infectious Diseases
2017-2024
City Of Hope National Medical Center
2023
Seattle Children's Hospital
2023
Emory University
2023
Fred Hutch Cancer Center
2023
Bacteremia is a frequent complication of allogeneic hematopoietic stem cell transplantation (allo-HSCT). It unclear whether changes in the intestinal microbiota during allo-HSCT contribute to development bacteremia. We examined patients undergoing allo-HSCT, and correlated microbial shifts with risk bacteremia.Fecal specimens were collected longitudinally from 94 before transplant until 35 days after transplant. The was characterized by 454 pyrosequencing V1-V3 region bacterial 16S ribosomal...
As of 10 April 2020, New York State had 180,458 cases severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) and 9,385 reported deaths. Patients with cancer comprised 8.4% deceased individuals1. Population-based studies from China Italy suggested a higher disease 2019 (COVID-19) death rate in patients cancer2,3, although there is knowledge gap as to which aspects its treatment confer risk COVID-194. This information critical balance the competing safety considerations reducing...
BACKGROUND. Understanding outcomes and immunologic characteristics of cellular therapy recipients with SARS-CoV-2 is critical to performing these potentially life-saving therapies in the COVID-19 era. In this study allogeneic (Allo) autologous (Auto) hematopoietic cell transplant CD19-directed chimeric antigen receptor T (CAR T) at Memorial Sloan Kettering Cancer Center, we aimed identify clinical variables associated severity assess lymphocyte populations.
Abstract Background Pneumonia is a common cause of morbidity and mortality, yet causative pathogen identified in minority cases. Plasma microbial cell-free DNA sequencing may improve diagnostic yield immunocompromised patients with pneumonia. Methods In this prospective, multicenter, observational study adults undergoing bronchoscopy to establish pneumonia etiology, plasma was compared standardized usual care testing. etiology adjudicated by blinded independent committee. The primary...
Clostridium difficile infection (CDI) is a frequent complication in recipients of allogeneic hematopoietic stem cell transplantation (allo-HSCT), who receive intensive treatments that significantly disrupt the intestinal microbiota. In this study, we examined microbiota composition allo-HSCT to identify bacterial colonizers confer protection against CDI after engraftment.Feces collected from adult at engraftment were analyzed; 16S ribosomal RNA genes sequenced and analyzed each sample....
Clostridium difficile infection (CDI) is frequently diagnosed in recipients of allogeneic hematopoietic stem cell transplantation (allo-HSCT). We characterized early-transplant CDI and its associations, analyzed serially-collected feces to determine intestinal carriage toxigenic C. difficile. Fecal specimens were collected longitudinally from 94 patients during allo-HSCT hospitalization, the start pre-transplant conditioning until up 35 days after infusion. Presence 16S rRNA tcdB genes was...
Adenovirus (ADV) is an important cause of viral mortality in hematopoietic stem cell transplantation (HSCT). Recipients T cell-depleted (TCD) HSCT are at increased risk for infections. We compared the rates and outcomes ADV viremia disease between TCD conventional (CONV) our institution. This was observational study 624 adult pediatric recipients myeloablative Memorial Sloan-Kettering Cancer Center January 1, 2006, March 11, 2011. Viral cultures PCR were ordered as clinically indicated. by...
New York State had 180,458 cases of SARS-CoV-2 and 9385 reported deaths as April 10 th , 2020. Patients with cancer comprised 8.4% deceased individuals 1 . Population-based studies from China Italy suggested a higher COVID-19 death rate in patients 2,3 although there is knowledge gap to which aspects its treatment confer risk severe disease 4 This information critical balance the competing safety considerations reducing exposure continuation. Since March 2020 Memorial Sloan Kettering Cancer...
Isavuconazole is a broad-spectrum triazole approved for treatment of invasive fungal infections (IFIs). In this open-label, single-arm study, we evaluated isavuconazole antifungal prophylaxis after allogeneic hematopoietic cell transplantation (HCT). Adult patients admitted first HCT received micafungin 150 mg i.v. daily from admission through day +7 (D+7) post-transplantation (±2 days) followed by (i.v./p.o. 372 every 8 hours 6 doses and then daily) maximum D+98 post-HCT. Patients were...
Abstract Limited understanding of the immunopathogenesis human herpesvirus 6B (HHV-6B) has prevented its acceptance as a pulmonary pathogen after hematopoietic cell transplant (HCT). In this prospective multicenter study patients undergoing bronchoalveolar lavage (BAL) for pneumonia allogeneic HCT, we test blood and BAL fluid (BALF) HHV-6B DNA mRNA transcripts associated with lytic infection perform RNA-seq on paired blood. Among 116 participants, is detected in 37% BALs, 49% which also have...
Invasive pulmonary infections are a significant cause of morbidity and mortality in patients with hematological malignancies hematopoietic stem cell transplantation (HCT) recipients. A delay identifying causative agent may result late initiation appropriate treatment adverse clinical outcomes. We examine the diagnostic utility PCR-based assays evaluating invasive from bronchoalveolar lavage (BAL). Patients HCT recipients who underwent bronchoscopy BAL January 2020 to 2024 for unexplained...
Abstract Background Invasive pulmonary infections are a significant cause of morbidity and mortality in patients with hematological malignancies hematopoietic stem cell transplantation (HCT) recipients. A delay identifying causative agent may result late initiation appropriate treatment worse outcomes. We explore the diagnostic utility incorporating commercially available polymerase chain reaction (PCR)-based assays performed on bronchoalveolar lavage (BAL) specimens into evaluating invasive...
Characteristics of Non-typhoidal Salmonella Isolates from Human and Broiler-chickens in Southwestern Seoul, KoreaNon-typhoidal (NTS) is an important commensal microorganism.The purpose this study was to determine the epidemiological relation between NTS isolates livestock human by analyzing antimicrobial susceptibilities performing molecular typing.We determined serotypes 36 clinical 64 isolates, performed susceptibility testing against 8 antibiotics, types isolated spp.by pulsed field gel...
What is known and objective Linezolid-induced thrombocytopenia one of the many confounding conditions in critically ill patients. It rare but prognostic importance linezolid-induced ICU population has not been well investigated. The study to assess incidence risk factors Methods We conducted a retrospective with patients treated linezolid between January 2005 December 2015 at adult medical, surgical, emergency, neurological ICUs 1500-bed tertiary university medical center. Results discussion...
Recipients of ex vivo T cell–depleted (TCD) hematopoietic cell transplantation (HCT) are at risk infection by double-stranded (ds) DNA viruses. We report rates dsDNA viremia, end-organ disease (EOD), infection-related mortality, and overall survival (OS) in a contemporary cohort adult TCD HCT recipients routinely monitored for cytomegalovirus (CMV), adenovirus (ADV), human herpesvirus 6 (HHV6), Epstein-Barr virus (EBV). Healthcare utilization the first months post-HCT was compared between...
Voriconazole is frequently discontinued prematurely as primary antifungal prophylaxis (AFP) in allogeneic hematopoietic cell transplant (HCT) recipients due to adverse events. Limited data exists for isavuconazole AFP. We analyzed adult HCT who received voriconazole or AFP estimate rate of premature discontinuation, identify risk factors and compare incidence invasive fungal infection (IFI) survival at day + 180 post-HCT between patients voriconazole/isavuconazole-AFP. This was a propensity...
Abstract Background Bacterial colonization is an essential aspect of bronchiectasis. Although Haemophilus influenzae a frequent colonizer in some regions, its clinical impacts are poorly understood. This study aimed to elucidate the impact H. patients with Methods retrospective screened adult diagnosed bronchiectasis at tertiary referral center between April 1, 2003, and May 16, 2021, South Korea. Propensity score matching was used match without colonization. We assessed severity as per...
Hematopoietic stem cell transplant (HSCT) recipients are at significant risk for BK virus (BKV) reactivation, hemorrhagic cystitis (HC), and renal dysfunction. We prospectively monitored 98 patients who had received HSCT by serial BKV PCR in the urine through day (D) +100 to analyze relationship between viruria HC, serum creatinine (Cr), clearance (CrCl) D +180 or death. Patients, median age 52 years (range, 20 73), T cell-depleted (50%) cord blood allografts (21%). Median pre-HSCT IgG...
Adenovirus (ADV) infections after hematopoietic cell transplantation (HCT) range in severity from self-limited to fatal. We have previously reported high mortality rates CD34(+) selected T cell-depleted (TCD) HCT recipients using symptomatic testing and culture methods for ADV detection. report outcomes of viremia 215 adult TCD the CliniMACS selection system. This was a prospective observational study adults transplanted March 21, 2012 through November 30, 2014 at Memorial Sloan-Kettering...
The applications of the 16S rRNA gene pyrosequencing has expanded our knowledge respiratory tract microbiome originally obtained using conventional, culture-based methods. In this study, we employed DNA-based molecular techniques for examining sputum in bronchiectasis patients, relation to disease severity. Of sixty-three study subjects, forty-two had mild and twenty-one moderate or severe bronchiectasis, which was classified by calculating FACED score, based on FEV₁ (forced expiratory...