A5002721802- Acute Myeloid Leukemia Research
- Hematopoietic Stem Cell Transplantation
- Acute Lymphoblastic Leukemia research
- Immune Cell Function and Interaction
- Myeloproliferative Neoplasms: Diagnosis and Treatment
- Blood disorders and treatments
- Chronic Myeloid Leukemia Treatments
- Neutropenia and Cancer Infections
- Immunodeficiency and Autoimmune Disorders
- Histone Deacetylase Inhibitors Research
- Chronic Lymphocytic Leukemia Research
- Lymphoma Diagnosis and Treatment
- Mycobacterium research and diagnosis
- Autoimmune and Inflammatory Disorders Research
- Multiple Myeloma Research and Treatments
- Pneumocystis jirovecii pneumonia detection and treatment
- CAR-T cell therapy research
- Polyomavirus and related diseases
- Cancer Genomics and Diagnostics
- Platelet Disorders and Treatments
- Lung Cancer Treatments and Mutations
- T-cell and B-cell Immunology
- Tuberculosis Research and Epidemiology
- Cancer-related Molecular Pathways
- Epigenetics and DNA Methylation
University of Ulsan
2016-2025
Ulsan College
2016-2025
Asan Medical Center
2016-2025
DDX41 mutations are associated with hematologic malignancies including myelodysplastic syndrome (MDS) and acute myeloid leukemia (AML), but the incidence in idiopathic cytopenia of undetermined significance (ICUS) is unknown. We investigated incidence, genetic characteristics, clinical features Korean patients ICUS, MDS, or AML. performed targeted deep sequencing 61 genes 457 ICUS (n=75), MDS (n=210), AML (n=172). Germline causality were identified 28 (6.1%) patients, whom 27 (96.4%) had...
We report a case of cytomegalovirus retinitis in hematopoietic stem cell transplant recipient during valganciclovir pre-emptive therapy followed by maribavir. Analysis UL97 mutation revealed C480F substitution associated with high maribavir resistance and low ganciclovir resistance.
The optimum method of donor natural killer cell infusion (DNKI) after allogeneic hematopoietic transplantation (HCT) remains unclear. Fifty-one patients (age range, 19 years to 67 years) with refractory acute leukemia underwent HLA-haploidentical HCT and DNKI on days 6, 9, 13, 20 HCT. Median doses were .5, 1.0, 2.0 × 108/kg cells, respectively. During DNKI, 33 the 45 evaluated (73%) developed fever (>38.3°C) along weight gain (median, 13%; 2% 31%) and/or hyperbilirubinemia 6.2 mg/dL; 1.0...
We performed a prospective study to determine the efficacy and safety of rituximab including chemotherapy in CD20-positive acute lymphoblastic leukemia (ALL).Patients with newly diagnosed ALL, aged ≥ 15 years, were eligible for if their leukemic blast cells bone marrow expressed CD20 20% at time diagnosis. Patients received multiagent rituximab. After achieving complete remission (CR), patients five cycles consolidation concomitant Rituximab was administered monthly from day 90...
To investigate the role of antithymocyte globulin (ATG)-containing reduced-intensity conditioning (RIC) in hematopoietic cell transplantation (HCT) from unrelated (UD) or haploidentical family donors (HFD), we conducted a phase 2 trial 237 patients (age range, 16 to 69 years) with acute myeloid leukemia (AML) remission. Patients undergoing UD-HCT (n = 93) HFD-HCT 59) received RIC comprising busulfan, fludarabine, and ATG, 9 mg/kg, whereas those HCT matched sibling (MSD, n 85) myeloablative...
Immune thrombocytopenia (ITP) is an autoimmune condition characterized by platelet destruction through antibody-mediated mechanism. ITP one of the manifestations a coronavirus disease, as well adverse event occurring after vaccination against severe acute respiratory syndrome 2 (SARS-CoV-2). Several cases have been described with two mRNA-based vaccines-BTN162b2 (Pfizer-BioNTech) and mRNA-1273 (Moderna)-against SARS-CoV-2. Herein, we report case ChAdOx1 adenovirus vector nCoV-19...
Summary Clonal cytopenia of undetermined significance (CCUS) is characterized by persistent cytopenias with genetic aberrations, which do not meet the diagnostic criteria for myelodysplastic syndrome (MDS). We aimed to compare clinical and characteristics CCUS lower‐risk MDS identify patients a high risk progression. performed targeted sequencing bone marrow (BM) samples from idiopathic (ICUS) ( n = 139) 226). Overall survival (OS) 78) was worse than non‐clonal ICUS 61) superior 99)....
Efforts to overcome poor outcomes in patients with adult acute lymphoblastic leukemia (ALL) have focused on combining new therapeutic agents targeting immunophenotypic markers (IPMs) classical cytotoxic agents; therefore, it is important evaluate the clinical significance of IPMs.Baseline characteristics and ALL were retrospectively analyzed. The percentage blasts expressing IPMs at diagnosis was measured by multicolor flow cytometry analysis. Samples which ≥20% expressed an IPM considered...
Abstract Background We analyzed expression profiles of immune checkpoint receptors on T cell subsets and ligands leukemic blasts in patients with B‐lymphoblastic leukemia (B‐ALL). Methods Total 149 bone marrow (BM) samples obtained from 65 B‐ALL four different clinical status (41 at diagnosis, 54 complete remission [CR], 34 persistence, 20 relapse), 32 BM control were prospectively enrolled. Expression receptor (programmed death protein‐1 [PD‐1]) (PD‐L1, PD‐L2) was evaluated by flow...
In hematopoietic stem cell transplant recipients, the incidence of tuberculosis in positive interferon-γ release assay (IGRA) without isoniazid prophylaxis (3.58/100 person-years) was higher than negative or indeterminate IGRA (1.15/100 person-years; P = .01) and with (0/100 .09). The number needed to treat 22 (95% confidence interval, 12-99) results.
This study presents outcomes of management in graft failure (GF) after allogeneic hematopoietic stem cell transplantation (HCT) and provides prognostic information including rare cases autologous reconstitution (AR).We analyzed risk factors primary secondary GF, occurrence AR 1,630 HCT recipients transplanted over period 18 years (January 2000-September 2017) at our center.Primary GF occurred 13 (0.80%), 69 patients (10-year cumulative incidence, 4.5%) respectively. No peri-transplant...
Our previous research indicated that a reduced-intensity conditioning regimen (fludarabine and melphalan at 100 mg/m2) was useful in allogeneic hematopoietic cell transplantation (HCT) for patients with lymphoma. This retrospective study evaluated the HCT adult hemophagocytic lymphohistiocytosis (HLH). Sixteen HLH were evaluated, including 6 who enrolled prospective clinical trial (NCT00772811) 10 received same 30 mg/m2/day on days -6 to -2 mg/m2 day -2). The median age 42 years (range, 18...
Abstract The prognosis of patients with acute leukemia relapsed after allogeneic hematopoietic stem cell transplantation (HSCT) is dismal. We aimed to evaluate the outcomes and prognostic factors second HSCT (HSCT2) in first (HSCT1). analyzed 80 who received HSCT2 for two Korean institutes. All but four from a donor other than matched sibling donor: an unrelated (URD) 30 familial haploidentical (FHD) 46. Forty‐four (55.0%) were complete remission (CR) or CR incomplete count recovery (CRi) at...
Disseminated Mycobacterium avium complex (MAC) infection can occur in immunocompromised patients, and rarely immunocompetent subjects. Due to the extensive distribution of disease, clinical presentation disseminated MAC may mimic malignancies, thorough examinations are required order make accurate diagnosis. We report a case intracellulare disease an patient, which involved lung, lymph nodes, spleen, multiple bones. F-18 fluorodeoxyglucose positron-emission tomography imaging showed...