A5026820173- Sepsis Diagnosis and Treatment
- Transplantation: Methods and Outcomes
- Hemodynamic Monitoring and Therapy
- Respiratory Support and Mechanisms
- Mechanical Circulatory Support Devices
- Intensive Care Unit Cognitive Disorders
- Organ Transplantation Techniques and Outcomes
- Nosocomial Infections in ICU
- Interstitial Lung Diseases and Idiopathic Pulmonary Fibrosis
- Emergency and Acute Care Studies
- Cardiac Arrest and Resuscitation
- Lung Cancer Treatments and Mutations
- SARS-CoV-2 and COVID-19 Research
- Hepatocellular Carcinoma Treatment and Prognosis
- Chronic Obstructive Pulmonary Disease (COPD) Research
- Renal Transplantation Outcomes and Treatments
- COVID-19 Clinical Research Studies
- Thermal Regulation in Medicine
- Clinical Reasoning and Diagnostic Skills
- Renal function and acid-base balance
- Lung Cancer Research Studies
- Machine Learning in Healthcare
- Bacterial Identification and Susceptibility Testing
- Pneumonia and Respiratory Infections
- Venous Thromboembolism Diagnosis and Management
Asan Medical Center
2012-2024
University of Ulsan
2010-2024
Ulsan College
2012-2024
Seoul National University Hospital
2021-2023
Samsung Medical Center
2013-2021
Sungkyunkwan University
2013-2017
Abstract Background Timely administration of antibiotics is one the most important interventions in reducing mortality sepsis. However, administering within a strict time threshold all patients suspected with sepsis will require huge amount effort and resources may increase risk unintentional exposure to broad-spectrum without infection its consequences. Thus, controversy still exists on whether clinicians should target different time-to-antibiotics thresholds for versus septic shock....
In Asian populations, the correlation between sepsis outcomes and body mass is unclear. A multicenter, prospective, observational study conducted September 2019 December 2020 evaluated obesity's effects on in a national cohort.Nineteen tertiary referral hospitals or university-affiliated South Korea.Adult patients with ( n = 6,424) were classified into obese 1,335) nonobese groups 5,089).Obese propensity score-matched ratio of 1:1. Inhospital mortality was primary outcome. After score...
Worldwide, sepsis is the leading cause of death in hospitals. If mortality rates patients with can be predicted early, medical resources allocated efficiently. We constructed machine learning (ML) models to predict a hospital emergency department.
Monocyte distribution width (MDW) has been suggested as an early biomarker of sepsis, but few studies have compared MDW with conventional biomarkers, including C-reactive protein (CRP) and procalcitonin (PCT). This study evaluated a for sepsis it CRP PCT.Patients aged 18-80 years who visited the emergency department were screened prospectively enrolled in tertiary medical center. Complete blood count, MDW, CRP, PCT examined. Diagnostic performance was tested using area under curve (AUC)...
Abstract Background Numerous epidemiological studies investigating gender-dependent clinical outcomes in sepsis have shown conflicting evidence. This study aimed to investigate the effect of gender on in-hospital mortality due according age group. Methods used data from Korean Sepsis Alliance, an ongoing nationwide prospective multicenter cohort 19 participating hospitals South Korea. All adult patients diagnosed with emergency departments between September 2019 and December 2021 were...
The prevalence of obesity is increasing in the intensive care unit (ICU). Although a known risk factor for chronic kidney disease, its association with early sepsis-associated acute injury (SA-AKI) and their combined patient outcomes warrant further investigation.
OBJECTIVES: Frailty is a multidimensional syndrome or state of increased vulnerability to poor resolution homoeostasis following stressor event. common in patients with sepsis. Sepsis and frailty are both associated older age chronic medical conditions. However, there limited evidence about the direct association between The aim this study determine preexisting clinical outcomes DESIGN: A nationwide propensity score–matched cohort analyzing data prospectively collected September 2019...
OBJECTIVES: To investigate whether administration of a vasopressor within 1 hour first fluid loading affected mortality and organ dysfunction in septic shock patients. DESIGN: Prospective, multicenter, observational study. SETTING: Sixteen tertiary or university hospitals the Republic Korea. PATIENTS: Patients with ( n = 415) were classified into early late groups according to was initiated resuscitative load. Early 149) patients 1:1 propensity matched INTERVENTIONS: None. Measurement Main...
Mortality rates associated with sepsis have increased progressively in Korea, but domestic epidemiologic data remain limited. The objective of this study was to investigate the characteristics, management and clinical outcomes patients Korea.This is a multicenter retrospective cohort study. A total 64,021 adult who visited an emergency department (ED) within one 19 participating hospitals during 1-month period were screened for eligibility. Among these, diagnosed based on third International...
Although bridge to lung transplantation (BTT) with extracorporeal membrane oxygenation (ECMO) is increasingly performed, the impact of BTT and its duration on post-transplant outcomes are unclear.We retrospectively reviewed medical records adult patients who underwent or heart-lung in our institution between January 2008 December 2018. Data were compared did (n = 41; BTT) not 36; non-BTT) require pre-transplant ECMO support. also short-term (<14 days; n 21; ST-BTT) long-term (≥14 20; LT-BTT)...
Background The understanding of shock indices in patients with septic is limited, and their values may vary depending on cardiac function. Methods This prospective cohort study was conducted across 20 university-affiliated hospitals (21 intensive care units [ICUs]). Adult (≥19 years) admitted to the ICUs during a 29-month period were included. index (SI), diastolic (DSI), modified (MSI), age (Age-SI) calculated at sepsis recognition (time zero) ICU admission. Left ventricular (LV) function...
Background: Successful liberation from mechanical ventilation is one of the most crucial processes in critical care because it first step by which a respiratory failure patient begins to transition out intensive unit and return their own life. Therefore, when devising appropriate strategies for removing ventilation, essential consider not only individual experiences healthcare professionals, but also scientific systematic approaches. Recently, numerous studies have investigated methods tools...
OBJECTIVES: In 2018, the Centers for Disease Control and Prevention introduced Adult Sepsis Event (ASE) definition, using electronic health records (EHRs) data surveillance sepsis quality improvement. However, regarding ASE outside United States remain limited. We therefore aimed to validate diagnostic accuracy of assess prevalence mortality ASE. DESIGN: Retrospective cohort study. SETTING: A single center in South Korea, with 2732 beds including 221 ICU beds. PATIENTS: During validation...
Abstract Background Although several trials were conducted to optimize the oxygenation range in intensive care unit (ICU) patients, no studies have yet reached a universal recommendation on optimal partial pressure of oxygen arterial blood (PaO 2 ) patients with sepsis. Our aim was evaluate whether relatively high tension is associated longer survival sepsis compared conservative tension. Methods From Korean Sepsis Alliance nationwide registry, treated liberal PaO ≥ 80 mm Hg) 1:1 matched...
Vitamin C has shown several beneficial effects on sepsis in preclinical studies. However, clinical data supporting these reports are scarce. This study aimed to evaluate whether adjunctive intravenous vitamin therapy could reduce hospital mortality patients with severe or septic shock requiring mechanical ventilation.For this retrospective cohort study, consecutive medical ICU ventilation were included. The classified into the control groups depending administration of (2 g every 8 hours)....
Right heart decompensation is a fatal complication in patients with respiratory failure, particularly those transitioned to lung transplantation using veno-venous extracorporeal membrane oxygenation (V-V ECMO). In these patients, veno-arterial (V-A ECMO) or veno-arterialvenous (V-AV used support both cardiac and function. However, processes may increase the risk of device-related complications such as bleeding, thromboembolism, limb ischemia. present case, 64-year-old male patient idiopathic...
Use of extracorporeal membrane oxygenation in patients with acute high-risk pulmonary embolism: a case series literature review Background: Although (ECMO) has been used for the treatment embolism (PE), there are limited reports which focus on this approach.Herein, we described our experience ECMO PE.Methods: We retrospectively reviewed medical records diagnosed highrisk PE and treated between January 2014 December 2018.Results: Among 16 included, median age was 51 years (interquartile range...
Background The current early warning scores may be insufficient for medical emergency teams (METs) to use in assessing the severity and prognosis of activated patients. We evaluated predictive powers Modified Early Warning Score (MEWS) National (NEWS) 28-day mortality analyze predictors general ward patients who activate MET. Methods Adult inpatients MET a tertiary referral teaching hospital between March 2009 December 2016 were included. demographic clinical characteristics physiologic...
Sepsis is a leading cause of mortality in patients with neutropenia; however, data on whether neutropenic sepsis associated distinct clinical characteristics and outcomes are limited. Thus, this study was designed to clarify the compared those without diagnosed based Third International Consensus Definitions for Septic Shock criteria.We analyzed from Korean Alliance, nationwide prospective multicenter cohort evaluating characteristics, management, September 2019 February 2020. Eligible were...
Administration of adequate antibiotics is crucial for better outcomes in sepsis. Because no uniform tool can accurately assess the risk multidrug-resistant (MDR) pathogens, a local antibiogram necessary. We aimed to describe MDR bacteria based on locations sepsis onset South Korea.We performed prospective observational study adult patients diagnosed with according Sepsis-3 from 19 institutions (13 tertiary referral and 6 university-affiliated general hospitals) Korea. Patients were divided...