A5058190706- Chronic Obstructive Pulmonary Disease (COPD) Research
- Sepsis Diagnosis and Treatment
- Antimicrobial Resistance in Staphylococcus
- Machine Learning in Healthcare
- Genomic variations and chromosomal abnormalities
- Pediatric health and respiratory diseases
- Inhalation and Respiratory Drug Delivery
- Pressure Ulcer Prevention and Management
- Folate and B Vitamins Research
- Single-cell and spatial transcriptomics
- Public Health and Nutrition
- Hydrological Forecasting Using AI
- Epigenetics and DNA Methylation
- Asthma and respiratory diseases
- Drug-Induced Adverse Reactions
- Fungal Infections and Studies
- Cancer Genomics and Diagnostics
- Antifungal resistance and susceptibility
- Immune cells in cancer
- Nail Diseases and Treatments
- Sleep and Work-Related Fatigue
- Contact Dermatitis and Allergies
- Frailty in Older Adults
- Analytical Methods in Pharmaceuticals
- Pneumonia and Respiratory Infections
Kangwon National University Hospital
2018-2025
Kangwon National University
2019-2025
Worldwide, sepsis is the leading cause of death in hospitals. If mortality rates patients with can be predicted early, medical resources allocated efficiently. We constructed machine learning (ML) models to predict a hospital emergency department.
Chronic obstructive pulmonary disease (COPD) is a leading cause of morbidity and mortality worldwide. Single-cell RNA sequencing (scRNA-seq) provides gene expression profiles at the single-cell level. Hence, we evaluated in peripheral blood patients with COPD. Peripheral samples from seven healthy controls eight COPD were obtained this study. The 10X Genomics Chromium Instrument cDNA synthesis kit utilized to generate barcoded library for single cell RNA-sequencing. We compared scRNA-seq...
Background/Objectives: The methacholine bronchial provocation test (MBPT) is a diagnostic frequently used to evaluate airway hyper-reactivity. MBPT essential for diagnosing asthma; however, it can be time-consuming and resource-intensive. This study aimed develop an artificial intelligence (AI) model predict the results using forced expiratory volume in one second (FEV1) bronchodilator measurements from spirometry. Methods: dataset of spirometry measurements, including Pre-...
Although physical activity is known to be beneficial lung function, few studies have been conducted investigate the correlation between and function in dusty areas. Therefore, purpose of this study a Korean cohort including normal COPD-diagnosed participants.Data obtained from COPD areas (CODA) was analyzed for following factors: symptoms, information about activity. Information on valuated using questionnaires, participants were categorized into two groups: active inactive. The evaluation...
Lung cancer is the leading cause of cancer-related deaths worldwide. Copy number variation (CNV) in several genetic regions correlate with susceptibility. Hence, this study evaluated association between CNV and non-small cell lung (NSCLC) peripheral blood.Blood samples 150 patients NSCLC normal controls were obtained from a bioresource center (Seoul, Korea). Through an epigenome-wide analysis using MethylationEPIC BeadChip method, we extracted CNVs by SVS8 software-supplied multivariate...
Vancomycin pharmacokinetics are highly variable in patients with critical illnesses, and clinicians commonly use population pharmacokinetic (PPK) models based on a Bayesian approach to dose. However, these population-dependent, may only sometimes meet the needs of individual patients, used by experienced as reference for making treatment decisions. To assist real-world clinicians, we developed deep learning-based decision-making system that predicts vancomycin therapeutic drug monitoring...
Pressure ulcers (PUs) are a prevalent skin disease affecting patients with impaired mobility and in high-risk groups. These increase patients’ suffering, medical expenses, burden on staff. This study introduces clinical decision support system verifies it for predicting real-time PU occurrences within the intensive care unit (ICU) by using MIMIC-IV in-house ICU data. We develop various machine learning (ML) deep (DL) models real time validate Kangwon National University Hospital (KNUH)...
Fluconazole is a triazole-based first-generation antifungal agent and has excellent effects on candidiasis cryptococcosis. Hyper sensitivity been reported as side effect of fluconazole. A 76-year-old female patient used fluconazole for consolidation therapy cryptococcal meningitis, but showed delayed hypersensitivity with skin rashes itching sensation the whole body. For de sensitization, was attempted by administering 12-step, 1:1 solutions were administered intravenously at sequentially...
Chronic obstructive pulmonary disease (COPD) is a progressive respiratory condition characterized by persistent inflammation in the airways, resulting narrowing and obstruction of air passages. The development COPD primarily attributed to long-term exposure irritants, such as cigarette smoke environmental pollutants. Among individuals hospitalized for exacerbations COPD, approximately one five readmitted within 30 days discharge or encounters immediate post-discharge complications,...
<b>Background:</b> Acid-suppressive medications (ASM) are increasingly used, especially in patients with underlying diseases. Long-term use of ASM causes various side effects. However, studies on the effects have report different results depending study design. Recently, researches using a Distributed Research Network (DRN) Common Data Model (CDM) become possible. Using DRN CDM, we confirmed hazard ratio pneumonia chronic obstructive pulmonary disease (COPD) after ASM. <b>Methods:</b>...
<b>Background:</b> Anemia is a well-known comorbidity of COPD. Previous studies regarding hemoglobin and polycythemia have been investigated to be associated with increased mortality. In this study , we aimed retrospectively investigate the risk mortality serum hemoglobin(Hb) concentration level in COPD patients. <b>Methods:</b> A retrospective cohort study was designed using the Korean National Health Insurance Service (NHIS) -National Sample Cohort...
서 론Nizatidine은 4세대 히스타민 H2 수용체 길항제로서 위궤양, 십 이지장궤양, 역류성식도염 및 스트레스성궤양에 사용된다
<sec> <title>BACKGROUND</title> Vancomycin pharmacokinetics are highly variable in patients with critical illnesses, and clinicians commonly use population pharmacokinetic (PPK) models based on a Bayesian approach to dose. However, these population-dependent, may only sometimes meet the needs of individual patients, used by experienced as reference for making treatment decisions. To assist real-world clinicians, we developed deep learning–based decision-making system that predicts vancomycin...