A5067962158- Chronic Obstructive Pulmonary Disease (COPD) Research
- Asthma and respiratory diseases
- Sepsis Diagnosis and Treatment
- RNA modifications and cancer
- Cancer-related molecular mechanisms research
- Tuberculosis Research and Epidemiology
- Lung Cancer Treatments and Mutations
- Respiratory Support and Mechanisms
- Machine Learning in Healthcare
- Lung Cancer Research Studies
- Air Quality and Health Impacts
- Pneumonia and Respiratory Infections
- MicroRNA in disease regulation
- Inhalation and Respiratory Drug Delivery
- Antimicrobial Resistance in Staphylococcus
- Pleural and Pulmonary Diseases
- Diagnosis and treatment of tuberculosis
- Mycobacterium research and diagnosis
- Neuroscience of respiration and sleep
- IL-33, ST2, and ILC Pathways
- Global Health Care Issues
- Bone and Dental Protein Studies
- Circular RNAs in diseases
- Restraint-Related Deaths
- Glutathione Transferases and Polymorphisms
Kangwon National University
2015-2025
Seoul National University
2006-2025
Kangwon National University Hospital
2013-2024
University of Illinois Chicago
2018
Worldwide, sepsis is the leading cause of death in hospitals. If mortality rates patients with can be predicted early, medical resources allocated efficiently. We constructed machine learning (ML) models to predict a hospital emergency department.
Abstract Background Muscle wasting is associated with prognosis in patients chronic obstructive pulmonary disease (COPD). The cross-sectional area of skeletal muscles on computed tomography (CT) could serve as a method to evaluate body composition. present study aimed determine the ability CT-derived pectoralis muscle (PMA) and density (PMD) severity COPD change longitudinal function COPD. Methods A total 293 participants were enrolled this study, whom 222 had undergone at least two...
<h3>Objective</h3> To assess the effect of <i>Ginkgo biloba</i> and clonazepam, a γ-aminobutyric acid (GABA)-receptor agonist, upon tinnitus. <h3>Methods</h3> This was an open-label, randomised, crossover study. 27 men 11 women (aged 16–80 (mean 58)) with tinnitus for more than 2 months were enrolled. Participants randomised to either clonazepam or <i>G first 3 weeks. For next weeks washout no medication taken. final weeks, subjects given other drug. The initial dose one tablet daily...
Background/Objectives: The methacholine bronchial provocation test (MBPT) is a diagnostic frequently used to evaluate airway hyper-reactivity. MBPT essential for diagnosing asthma; however, it can be time-consuming and resource-intensive. This study aimed develop an artificial intelligence (AI) model predict the results using forced expiratory volume in one second (FEV1) bronchodilator measurements from spirometry. Methods: dataset of spirometry measurements, including Pre-...
Cadmium (Cd), a major component of cigarette smoke, disrupts the normal functions airway cells and can lead to development various pulmonary diseases such as chronic obstructive disease (COPD). However, molecular mechanisms involved in Cd-induced are poorly understood. Here, we identified cluster genes that altered response Cd exposure human bronchial epithelial (BEAS-2B) demonstrated ER stress inflammation mediated via CCAAT-enhancer-binding proteins (C/EBP)-DNA-damaged-inducible transcript...
Background: There is growing evidence about sex-related phenotypes of COPD. However, the sex differences in COPD mainly result from smokers. This study evaluated nonsmoking patients with COPD, focusing on structural changes lungs airway diseases and emphysema. Methods: Ninety-seven patients, defined as having <1 pack-year lifetime cigarette smoking, diagnosed were selected a Korean cohort. Emphysema extent mean wall area percentage (WA%) computed tomography compared between male female...
Osteopontin (OPN) and carbonic anhydrase IX (CAIX), which are expressed on the surface of tumor cells, associated with hypoxia during development progression. However, roles these proteins in plasma patients non-small cell lung cancer (NSCLC) poorly understood. Herein, we hypothesized that OPN CAIX levels could be used as diagnostic prognostic markers NSCLC.Fifty-three NSCLC 50 healthy control subjects were enrolled. We selected controls without malignancy matched them patient cases...
Chronic obstructive pulmonary disease (COPD) is a heterogeneous with variable clinical manifestations, structural changes, and treatment responses. In cohort study, we performed baseline cluster analysis to identify the subgroups of COPD assess outcomes each subgroup during 1-year follow-up. We analyzed dusty areas comprising 272 patients COPD. The main factors highest loading in 15 variables were selected using principal component (PCA) at baseline. classified by hierarchical clinical,...
Cerebral air embolism is a rare but fatal complication of central venous catheterization.Here, we report case paradoxical cerebral associated with catheterization.An 85-yr-old man underwent right internal jugular vein catheterization, and became obtunded.Brain MR imaging CT revealed acute infarction multiple bubbles on the side catheter insertion.The possibility should be considered in patients developing neurological impairment after efforts made to limit damage.
MicroRNAs (miRNAs) are single‑stranded RNA species that constitute a class of non‑coding RNAs, and emerging as key regulators gene expression. Since each miRNA is capable regulating multiple genes, miRNAs attractive markers for studies coordinated In this study, we investigated expression profiling using massively parallel sequencing technique to compare non‑small‑cell lung cancer (NSCLC) tissue normal tissue. Lung were obtained from nine NSCLC patients. isolated these samples was processed...
Abstract Introduction and Objectives Although tobacco smoking is a major risk factor for chronic obstructive pulmonary disease (COPD), more than one‐fourth of COPD patients are non‐smokers. In this cross‐sectional study, the differences in phenotypes between non‐smokers smokers male subjects were investigated focused on structural lung changes using quantitative assessment computed tomography (CT) images. Methods They divided participants with COPD, from Korean cohort near cement plant, into...
Abstract Human pluripotent stem cell (hPSC)-derived alveolar epithelial cells (AECs) provide new opportunities for understanding lung development and the treatment of pulmonary diseases. However, toxicity assessments using hPSC-AECs have not been undertaken. In this study, we generated functional AECs from hPSCs evaluated their inflammatory apoptotic responses to cadmium (Cd) exposure (1, 5, 10 μM) 24 h compared with human bronchial line (BEAS-2B) primary as controls. Our data showed that Cd...
Various studies have investigated the association between pulmonary tuberculosis (TB) and lung cancer However, how relationship TB may differ by age is not yet clear. This study risk for after age.This used National Health Insurance Service-National Sample Cohort in South Korea. We compared 3,776 patients with 18,880 controls matched sex during period from 2003 to 2013. analyzed incidence of diagnosis active TB. A multivariate Cox proportional hazard model was calculate adjusted ratio (HR)...
The aim of this study was to determine candidemia incidence among patients in a medical intensive-care unit (MICU) and the associated mortality rate identify risk factors with candidemia. We retrospectively performed 1:3 matched case-control MICU Controls were for sex, age, Acute Physiology Chronic Health Evaluation (APACHE) II score. Candidemia 9.1 per 1,000 admissions. most common pathogen Candida albicans. Crude 96% 52% controls (P<0.001). Mortality differed significantly between groups...
Vitamin D levels are associated with the extent of mycobactericidal activity. Interleukin (IL)-15 and IL-32 play roles in vitamin D-mediated tuberculosis (TB) defense mechanism. induces IL-1β, which plays an important role terms resistance to TB. We evaluated whether D-related cytokines distinguished between those active TB latent infection (LTBI). In total, 50 TB-infected patients (25 25 LTBI following a outbreak high school) were enrolled. Plasma 25-hydroxyvitamin (25[OH]D), IL-15, IL-32,...
Background: Lung cancer is the most common cause of cancer-related mortality worldwide.We previously reported identification a new genetic marker, cellular retinoic acid binding protein 2 (CRABP2), in lung tissues.The aim this study was to assess plasma levels CRABP2 from patients with non-small cell (NSCLC).Methods: Blood samples that were collected 122 NSCLC between September 2009 and 2013 selected for analysis, along age-(± 5 years), sex-, cigarette smoking history (± 10 pack-years...
Objective Healthcare workers (HCWs) are one of the target groups for systematic testing and treatment latent tuberculosis infection (LTBI) in a setting low TB incidence. We performed this study to describe HCWs LTBI analyse acceptance completion LTBI. Methods This retrospective cohort was conducted four university-affiliated hospitals between January 1 December 31, 2018. with positive interferon-gamma release assay (IGRA) during screening were analysed. assessed treatment. Results Overall,...
Objective: Asthma and chronic obstructive pulmonary disease (COPD) have distinct pathophysiological mechanisms but sometimes share similar clinical manifestations. Distinguishing between these diseases is important. This study compared the profiles of serum biomarkers patients with asthma those COPD. Methods: Serum levels chitinase like protein YKL-40, periostin, interleukin (IL)-18, chemokine (C--C motif) ligand 18 (CCL18) were measured in (n = 20), COPD 16), normal controls 20). Results:...
Lung cancer is the leading cause of cancer-related deaths worldwide. Copy number variation (CNV) in several genetic regions correlate with susceptibility. Hence, this study evaluated association between CNV and non-small cell lung (NSCLC) peripheral blood.Blood samples 150 patients NSCLC normal controls were obtained from a bioresource center (Seoul, Korea). Through an epigenome-wide analysis using MethylationEPIC BeadChip method, we extracted CNVs by SVS8 software-supplied multivariate...