A5101651498- Photorefractive and Nonlinear Optics
- Cancer Genomics and Diagnostics
- Advanced Optical Imaging Technologies
- Molecular Biology Techniques and Applications
- Digital Holography and Microscopy
- Environmental DNA in Biodiversity Studies
- Photonic and Optical Devices
- Genetic Mapping and Diversity in Plants and Animals
- Meningioma and schwannoma management
- Virtual Reality Applications and Impacts
- Genomics and Phylogenetic Studies
- Crop Yield and Soil Fertility
- Pituitary Gland Disorders and Treatments
- Diverse Approaches in Healthcare and Education Studies
- Adrenal and Paraganglionic Tumors
- Genetic factors in colorectal cancer
- MicroRNA in disease regulation
- Optical measurement and interference techniques
- Cancer-related molecular mechanisms research
- Epigenetics and DNA Methylation
- Image Processing Techniques and Applications
- Genomics and Rare Diseases
- Cardiovascular Health and Risk Factors
- HER2/EGFR in Cancer Research
- Advanced Fiber Laser Technologies
Hallym University Sacred Heart Hospital
2024-2025
Hallym University
2024
Sungkyunkwan University
2018-2024
Kangbuk Samsung Hospital
2024
Samsung Medical Center
2017-2023
Loras College
2023
Samsung (South Korea)
2014-2023
Pohang University of Science and Technology
2021
Kangwon National University
2009-2020
Korea University
2020
Single-cell RNA-seq reveals the cellular heterogeneity inherent in population of cells, which is very important many clinical and research applications. Recent advances droplet microfluidics have achieved automatic isolation, lysis, labeling single cells compartments without complex instrumentation. However, barcoding errors occurring cell encapsulation process because multiple-beads-in-droplet insufficient throughput low concentration beads for avoiding multiple-beads-in-a-droplet remain...
To examine the effects of high-fat diet (HFD) on melanoma progression, HFD-fed C57BL/6N mice were subcutaneously injected with syngeneic B16F10 cells. At 3 weeks post-injection, tumors resected; then sacrificed at 2 post-resection. HFD stimulated growth and lymph node (LN) metastasis as well tumor LN lymphangiogenesis. Lipid vacuoles in M2-macrophage (MΦ)s adipose tissues increased mice. CCL19 CCL21 contents higher LNs than tumors. both levels CCR7 Adipose tissue-conditioned media (CM) from...
Flowering time is an important factor determining yield and seed quality in maize. A change flowering a strategy used to survive abiotic stresses. Among stresses, drought can increase anthesis-silking intervals (ASI), resulting negative effects on maize yield. We have analyzed the correlation between stress using RNA-seq bioinformatics tools. Our results identified total of 619 genes 126 transcripts whose expression was altered by B73 leaves under short-day condition. responsive genes, we...
Targeted deep sequencing is increasingly used to detect low-allelic fraction variants; it therefore essential that errors constitute baseline noise and impose a practical limit on detection are characterized. In the present study, we systematically evaluate extent which incurred during specific steps of capture-based targeted process. We removed most artifacts by filtering out low-quality bases then analyze remaining background noise. By recognizing plasma DNA naturally fragmented be size...
Targeted deep sequencing across broad genomic regions has been used to detect circulating tumor DNA (ctDNA) in pancreatic ductal adenocarcinoma (PDAC) patients. However, since most PDACs harbor a mutation KRAS, of needs be systemically compared analyzing only KRAS mutations for PDAC. Using capture-based targeted sequencing, we detected somatic 17 fine needle aspiration biopsy and 69 longitudinal cell-free (cfDNA) samples from PDAC were 10 out pretreatment patient plasma samples. Next,...
Background/Objectives: Dynapenia, age-associated loss in muscle strength, is an emerging risk factor for atherosclerotic cardiovascular disease (ASCVD), which may have different effects depending on sex. This study aims to investigate the association between dynapenia and ASCVD risk, evaluate its predictive significance among traditional factors, explore sex-specific patterns through machine learning models. Methods: retrospective case–control uses data from 19,582 participants aged 40–79...
<sec> <title>BACKGROUND</title> The risk of developing atherosclerotic cardiovascular disease (ASCVD) varies among individuals and is related to a variety lifestyle factors in addition the presence chronic diseases. </sec> <title>OBJECTIVE</title> We aimed assess predictive accuracy machine learning (ML) models incorporating behaviors for ASCVD using Korean nationwide database. <title>METHODS</title> Utilizing data from Korea National Health Nutrition Examination Survey, five ML algorithms...
Abstract Background Although the invasive lobular carcinoma (ILC) is second most frequent histologic subtype in Western countries, its incidence much lower Asia, and characteristics are less well known. Methods We assessed clinical outcomes of 83 Korean patients (2.8%) with ILC for comparison 2,833 (97.2%) ductal (IDC), including 1,088 (37.3%) luminal A (LA-IDC). Results The mean age all was 48.2 years, no significant differences among groups. Compared to IDC, showed a larger tumor size...
To identify complex cases of tympanojugular paraganglioma (TJP) and to analyze their management surgical outcome. present strategy guidelines on how deal with the perioperative complicating factors.Retrospective analysis.We retrospectively studied 212 TJP patients analyzed The criteria for are: 1) very large size; 2) intradural extension (IDE); 3) cavernous sinus, foramen magnum, clivus; 4) significant involvement internal carotid artery (ICA); 5) a solitary ICA lesion side; 6) vertebral...
In the integral imaging system, viewing angle is limited by size and focal length of elemental lens. this regard, we propose a new method for enhancement in InIm. The proposed employs refractive index medium between image plane lens array. enhanced InIm display analyzed based on terms. experimental result shows that doubled.
Supplementation with n-3 long-chain (LC) polyunsaturated fatty acids (PUFA) is known to promote thermogenesis via the activation of brown adipose tissue (BAT). Agricultural products that are biofortified α-linolenic acid (ALA), precursor LC PUFA, have been launched market, but their impact on BAT function unknown. This study aimed evaluate effects ALA-biofortified butter lipid metabolism and thermogenic functions in BAT. C57BL/6 mice were fed a high-fat diet containing (n3Bu, 45% calorie...
Purpose The feasibility of sequencing circulating tumor DNA (ctDNA) in plasma as a biomarker to predict early relapse or poor prognosis patients with follicular lymphoma (FL) receiving systemic immunochemotherapy is not clear.Materials and Methods We sequenced from cell-free that was serially obtained newly diagnosed FL undergoing immunochemotherapy. mutation profiles ctDNA at the time diagnosis response evaluation and/or progression were compared clinical course treatment outcomes.Results...
Background: Patients with chronic obstructive pulmonary disease (COPD) have a high risk of developing lung cancer. Due to the rates complications from invasive diagnostic procedures in this population, detecting circulating tumor DNA (ctDNA) as non-invasive method might be useful. However, clinical characteristics that are predictive ctDNA mutation detection remain incompletely understood. This study aimed investigate factors associated COPD patients Methods: Herein, 177 and cancer were...
We propose a depth extraction method by using the correlation between an elemental image and periodic function in computational integral imaging. Because each corresponds to different perspective of three-dimensional (3-D) object, is regarded as sum spatial frequencies depending on 3-D object. In this regard, we analyze property same functions vice versa. To show feasibility proposed method, carried out our experiment presented results.
Abstract Background The classic infratemporal fossa type A approach (IFTA‐A) permits superior and anterior exposure of the jugular foramen. transcondylar‐transtubercular extension facilitates posteroinferior medial access to purpose this study was present IFTA‐A with assess its surgical results. Methods review patients tympanojugular paraganglioma who underwent resection through performed. Results In all, 39 were included in study. average follow‐up 23.6 months. Gross total tumor removal...
DNA methylation markers are considered robust diagnostic features in various cancer types, as epigenetic marks commonly altered during progression. Differentiation between benign prostatic hyperplasia (BPH) and early-stage prostate (PCa) is clinically difficult, relying on the information of patient's symptoms or levels prostate-specific antigen.A total 42 PCa patients 11 BPH were recruited. Genomic was purified from tissues used for library preparation target-enriched methylome with...
Although targeted deep sequencing of cell-free DNA (cfDNA) was recently used to investigate tumor somatic mutations in particular subtypes non-Hodgkin lymphomas (NHLs), the immense genetic heterogeneity across poses a hurdle design universal gene panel applicable for diverse NHLs. We designed targeting 66 genes associated with NHLs and performed analyze plasma cfDNA from patients various Genetic profiling using method resulted 88.0% sensitivity >99% specificity detecting present at frequency...
MicroRNAs (miRNAs) are single‑stranded RNA species that constitute a class of non‑coding RNAs, and emerging as key regulators gene expression. Since each miRNA is capable regulating multiple genes, miRNAs attractive markers for studies coordinated In this study, we investigated expression profiling using massively parallel sequencing technique to compare non‑small‑cell lung cancer (NSCLC) tissue normal tissue. Lung were obtained from nine NSCLC patients. isolated these samples was processed...
Customized gene-panel tests, based on next-generation sequencing, have demonstrated their usefulness in a plethora of clinical settings. As with other diagnostic techniques, sequencing for purposes requires precise quality control (QC) measures to ensure its reliability. Only detected variants are currently recorded reports; however, identifying whether nondetected variant is true or false negative regarded essential setting and, thus, comprehensive QC measure demand. Conventional metrics,...
We propose a method to implement speckle-reduced coherent three-dimensional (3D) display system by combination of integral imaging and photorefractive volume holographic storage. The 3D real object is imaged through the microlens array stored in crystal. During reconstruction process phase conjugate reading beam used minimize aberration, rotating diffuser located on plane lens employed reduce speckle noise. image with wide viewing angle can be reconstructed use proposed system. Experimental...
Omega-3 fatty acids, such as eicosapentaenoic acid (EPA) and docosahexaenoic (DHA), have anti-inflammatory properties recently been considered essential factors for maintaining muscle health. This study aimed to investigate the relationship between omega-3 intakes sarcopenia by assessing grip strength in elderly Koreans who are at risk of sarcopenia. was conducted on 5529 individuals (2449 males 3080 females) aged ≥65 years from raw data Korea National Health Nutrition Examination Survey...
Epidemiologic studies have shown an association between tuberculosis and lung cancer. The al-tered tumor microenvironment after infection appears to contribute cancer pro-gression. Pleural effusions are enriched in exosomes, which act as mediators of intercellular communication. We hypothesized that tuberculous pleural effusion (TPE)-derived exosomes mediate Then we examined the interaction TPE-derived cells. Exosomal miRNA profiling TPE was performed using a microRNA array. An vitro cell...