A5064250591- Adipose Tissue and Metabolism
- Diet and metabolism studies
- Fatty Acid Research and Health
- Cancer-related Molecular Pathways
- Dietary Effects on Health
- Mitochondrial Function and Pathology
- Adipokines, Inflammation, and Metabolic Diseases
- DNA Repair Mechanisms
- Ferrocene Chemistry and Applications
- Microtubule and mitosis dynamics
- Lymphoma Diagnosis and Treatment
- Phytochemicals and Antioxidant Activities
- Birth, Development, and Health
- Metal complexes synthesis and properties
- Liver Disease Diagnosis and Treatment
- Cancer-related gene regulation
- Acute Myeloid Leukemia Research
- Circadian rhythm and melatonin
- Diet, Metabolism, and Disease
- Diabetes Treatment and Management
- Bioactive Compounds in Plants
- Viral-associated cancers and disorders
- Exercise and Physiological Responses
- Genetic factors in colorectal cancer
- Bariatric Surgery and Outcomes
University of Massachusetts Amherst
2024-2025
Shanghai Jiao Tong University
2024
Anhui Medical University
2024
Nanjing University of Chinese Medicine
2019-2022
University of Nebraska–Lincoln
2017-2021
First Affiliated Hospital of Xi'an Jiaotong University
2021
Xinqiao Hospital
2016-2021
Army Medical University
2016-2021
Chongqing Medical University
2021
Second Affiliated Hospital of Chongqing Medical University
2021
Obesity, which is caused by an energy imbalance between calorie intake and consumption, has become a major international health burden. Obesity increases the risk of insulin resistance age-related cognitive decline, accompanied peripheral inflammation. (—)-Epigallocatechin-3-gallate (EGCG), polyphenol in green tea, possesses antioxidant, anti-inflammatory, cardioprotective activities; however, few reports have focused on its potential effect disorders. In this study, our goal was to...
Neuroinflammation has been intensively demonstrated to be related various neurodegenerative diseases including Parkinson's disease (PD), amyotrophic lateral sclerosis (ALS), and Alzheimer's (AD). A natural polymethoxylated flavone, nobiletin (NOB) reported alleviate oxidative stress, insulin resistance, obesity. In this study, we evaluated the protection effects of NOB on neuroinflammation memory deficit. Three-month mice were administrated with by oral gavage every day for 6 weeks (100...
Immunogenic cell death (ICD) can engage a specific immune response and establish long-term immunity in hepatocellular carcinoma (HCC). Herein, we design synthesize series of Pt(II)-N-heterocyclic carbene (Pt(II)-NHC) complexes derived from 4,5-diarylimidazole, which show strong anticancer activities vitro. Among them, 2c displays much higher than cisplatin other Pt(II)-NHC complexes, especially HCC cancer cells. In addition, find that is type II ICD inducer, successfully induce endoplasmic...
Background/Objectives: Menopause induces substantial metabolic changes, including a reduction in rate and an elevated risk of developing diseases. Fish oil (FO) supplementation has been shown to ameliorate menopause-associated risks. Hyperthermia treatment (HT) recently gained attention for its potential improve immune health. However, it remains be determined whether HT can confer benefits comparable those FO or enhance the supplementation. This study aims delineate distinctive...
Abstract DNA-dependent protein kinase catalytic subunit (DNA-PKcs) is well known as a critical component involving the nonhomologous end joining pathway of DNA double-strand breaks repair. Here, we showed another important role DNA-PKcs in stabilizing spindle formation and preventing mitotic catastrophe response to damage. Inactivation by small interfering RNA or specific inhibitor NU7026 resulted an increased outcome polyploidy after 2-Gy 4-Gy irradiation. Simultaneously, high incidence...
Objective Urolithin A (UroA) is a major metabolite of ellagic acid produced following microbial catabolism in the gut. Emerging evidence has suggested that UroA modulates energy metabolism various cells. However, UroA’s physiological functions related to obesity and insulin resistance remain unclear. Methods Male mice were intraperitoneally administrated either or dimethyl sulfoxide (vehicle) along with high‐fat diet for 12 weeks. Insulin sensitivity was evaluated via glucose tolerance tests...
Soluble dietary fiber (DF) reduces the risk of developing diabetes and may have therapeutic effects in patients with type 2 mellitus (DM2). The present study aimed to investigate effect soluble DF on metabolic control DM2. A total 117 DM2 between ages 40 70 were assessed. Patients randomly assigned one two groups, administered extra (10 or 20 g/day), a group (0 g/day) for month. Blood glucose, serum insulin connecting peptide (C-peptide) levels, resistance index, as determined using...
Abstract Many cancer cells critically rely on antioxidant systems for cell survival and are vulnerable to further oxidative impairment triggered by agents generating reactive oxygen species (ROS). Therefore, the classical design development of inhibitors that target defense enzymes such as thioredoxin reductase (TrxR) can be a promising anticancer strategy. Herein, it is shown gold(I) complex containing an oleanolic acid derivative ( 4 b ) induces apoptosis ovarian A2780 activating...
Nonalcoholic fatty liver disease (NAFLD) is one of the common causes chronic in world.The problem NAFLD had become increasingly prominent.However, its pathogenesis still indistinct.As we all know, begins with accumulation triglyceride (TG), leading to degeneration, inflammation and other tissues damage.Notably, structure nucleoporin 85 (NUP85) related lipid metabolism diseases.In this study, results researches indicated that NUP85 played a critical role NAFLD.Firstly, expression level...
Together with cell cycle checkpoint control, DNA repair plays a pivotal role in protecting the genome from endogenous and exogenous damage. Although increased genetic instability has been associated prostate cancer progression, relative of double-strand break malignant versus normal epithelial cells is not known. In this study, we determined RNA protein expression series genes both (PrEC-epithelial PrSC-stromal) (LNCaP, DU-145, PC-3) cultures. Expression downstream ATM after ionizing...
A series of halo and pseudohalo gold(I)–NHC complexes (NHC–Au–X) (X = Cl, Br, I, NCO, OAc) derived from 4,5-diarylimidazoles were synthesized, structurally characterized, analyzed for their biological activities. The most active complex was iodo(1,3-diethyl-4,5-bis(4-methoxyphenyl)imidazol-2-ylidene)gold(I) (6), which at least 2-fold more cytotoxic than cisplatin auranofin against hepatocellular carcinoma (HCC) cells. In vivo studies indicated that 6 exhibited a considerably higher...
Abstract Aim Aging decreases the metabolic rate and increases risk of diseases, highlighting need for alternative strategies to improve health. Heat treatment (HT) has shown various benefits, but its ability counteract aging‐associated slowdown remains unclear. This study aimed investigate impact whole‐body HT on energy metabolism, explore potential mechanism involving heat sensor TRPV1, examine modulation gut microbiota. Methods Ten‐month‐old female C57BL/6 mice a high‐fat (HF) diet (45%...
Lotus seedpod procyanidins (LSPCs) could effectively prevent learning and memory damage oxidative caused by extremely low frequency electromagnetic field (ELF-EMF) exposure. However, LSPCs protect neurons from ELF-EMF-induced mechanisms currently not clear. An excessive release of glutamate is considered to be one the molecular neuronal in several neurological diseases. In this study we determined whether ELF-EMF (50 Hz, 8 mT, 28 days) exposure induced alterations mice hippocampus explored...
Early-onset preeclampsia (EOS-PE) refers to that occurred before 34 gestation weeks. This study is conducted explore the relationship between mitochondrial dysfunction and pathogenesis of EOS-PE using proteomic strategy.To identify altering expressed proteins severe healthy pregnancies, enrichment mitochondria coupled with iTRAQ-based quantitative method performed. Immunohistochemistry (IHC) western blot are performed detect alteration changing expression proteins, confirmed accuracy...
Abstract Background Medulloblastoma comprises approximately 20% of all primary pediatric brain tumors. Despite recent advances, the survival rate for high‐risk patients and morbidity associated with these treatments remains suboptimal. To improve outcomes decrease morbidity, more targeted therapy is required. One possible target Aurora Kinase family. The objective this study was to evaluate impact A inhibition in medulloblastoma cell lines. Procedure Cell proliferation measured using an MTS...
Supplementation with n-3 long-chain (LC) polyunsaturated fatty acids (PUFA) is known to promote thermogenesis via the activation of brown adipose tissue (BAT). Agricultural products that are biofortified α-linolenic acid (ALA), precursor LC PUFA, have been launched market, but their impact on BAT function unknown. This study aimed evaluate effects ALA-biofortified butter lipid metabolism and thermogenic functions in BAT. C57BL/6 mice were fed a high-fat diet containing (n3Bu, 45% calorie...