A5101547590- Schizophrenia research and treatment
- Diet and metabolism studies
- Tryptophan and brain disorders
- Gestational Diabetes Research and Management
- Bipolar Disorder and Treatment
- Birth, Development, and Health
- Pregnancy and preeclampsia studies
- Metabolism, Diabetes, and Cancer
- Bariatric Surgery and Outcomes
- Spaceflight effects on biology
- Neurological Disease Mechanisms and Treatments
- Circadian rhythm and melatonin
- Diabetes Treatment and Management
- Child and Adolescent Psychosocial and Emotional Development
- Phytochemistry and biological activity of medicinal plants
- Biochemical Acid Research Studies
- Thyroid Cancer Diagnosis and Treatment
- Cholesterol and Lipid Metabolism
- Traditional Chinese Medicine Analysis
- Cancer Risks and Factors
- Pituitary Gland Disorders and Treatments
- Mitochondrial Function and Pathology
- Barrier Structure and Function Studies
- Ginseng Biological Effects and Applications
- Acute Ischemic Stroke Management
Second Xiangya Hospital of Central South University
2008-2025
Central South University
2012-2025
VA San Diego Healthcare System
2012-2025
University of California, San Diego
2012-2025
University of Illinois Chicago
2012-2025
Nathan Kline Institute for Psychiatric Research
2025
Xiangya Hospital Central South University
2008-2025
Columbia University
2025
First Affiliated Hospital of Zhengzhou University
2025
New York University
2025
Weight gain, a common adverse effect of antipsychotic medications, is associated with medical comorbidities in psychiatric patients.To test the efficacy lifestyle intervention and metformin alone combination for antipsychotic-induced weight gain abnormalities insulin sensitivity.A randomized controlled trial (October 2004-December 2006) involving 128 adult patients schizophrenia Mental Health Institute Second Xiangya Hospital, Central South University, China. Participants who gained more...
Data on the treatment of antipsychotic-induced amenorrhea, particularly when occurring with weight gain, are limited. The authors investigated efficacy and safety metformin in amenorrhea gain women first-episode schizophrenia. Eighty-four (ages 18-40 years) schizophrenia who suffered from during antipsychotic were randomly assigned, a double-blind study design, to receive 1000 mg/day or placebo addition their for 6 months. primary outcome measures restoration menstruation change body mass...
Abstract Drug delivery systems have become a research priority in the biomedical field. The incorporation of liposomes to hydrogels further forms more robust multifunctional for effective and sustained topical drug delivery. In this study, carboxymethyl‐modified chitosan/hyaluronic acid (CMC/HA, CMH) thermosensitive hydrogel is developed transdermal liposomes. Hydrogels are crosslinked by hydrogen bonding, hydrophobic interaction electrostatic interaction. gel properties can be regulated...
Objective: There are few established treatments for negative symptoms in schizophrenia, which persist many patients after positive reduced.Oxidative stress, inflammation, and epigenetic modifications involving histone deacetylase (HDAC) have been implicated the pathophysiology of schizophrenia.Sulforaphane has antioxidant properties is an HDAC inhibitor.We conducted a 24-week, double-blind, placebo-controlled study, Hunan, China, to assess effect high-dose sulforaphane (Nutramax extra...
OBJECTIVE—The aim of this study was to investigate the prevalence gestational diabetes mellitus (GDM) and risk factors for development GDM in pregnant women Tianjin, China, where is still unknown. STUDY DESIGN AND METHODS—A total 9,471 living six urban districts took part initial screening between December 1998 1999. The test consisted a 50-g 1-h glucose test. Women with reading ≥7.8 mmol/l at were invited undergo 75-g 2-h oral tolerance (OGTT). confirmed using World Health Organization’s...
Dyslipidemia is one of the most common adverse effects in schizophrenia patients treated with antipsychotics. However, there are no established effective treatments. In this study, data were pooled from two randomized, placebo-controlled trials, which originally designed to examine efficacy metformin treating antipsychotic-induced weight gain and other metabolic abnormalities. total, 201 dyslipidemia after being an antipsychotic assigned take 1000 mg day-1 (n=103) or placebo (n=98) for 24...
BackgroundBile acid metabolism plays an important role in but it is uncertain whether bile metabolites early pregnancy are associated with risk of gestational diabetes mellitus (GDM).MethodsWe organized a 1:1 case-control study nested prospective cohort 22,302 pregnant women recruited from 2010 to 2012 China: 243 GDM were matched non-GDM controls on age (±1 year). Conditional logistic regression and restricted cubic spline used examine full-range associations GDM.FindingsAll the 9 detectable...
Abstract Objective. There is a notable need of quantifiable and objective methods for the classification schizophrenia. Patients with schizophrenia exhibit atypical eye movements compared healthy individuals. To address this need, we have developed model based on eye-tracking data to assist physicians in intelligent auxiliary diagnosis Approach. This study employed three experiments—Picture-Free Viewing, Smooth Pursuit Tracking, Fixation Stability—to collect from patients controls. The 292...
Early-onset preeclampsia (EOS-PE) refers to that occurred before 34 gestation weeks. This study is conducted explore the relationship between mitochondrial dysfunction and pathogenesis of EOS-PE using proteomic strategy.To identify altering expressed proteins severe healthy pregnancies, enrichment mitochondria coupled with iTRAQ-based quantitative method performed. Immunohistochemistry (IHC) western blot are performed detect alteration changing expression proteins, confirmed accuracy...
Antipsychotic intake may induce weight gain in drug-naive individuals with schizophrenia, leading to poor compliance clinical management. However, there is still a lack of effective approaches treat or prevent this side-effect. Therefore, we conducted pilot study investigate the effect continuous theta burst stimulation (cTBS), non-invasive magnetic technique, on preventing olanzapine-induced gain. Thirty-nine first-episode schizophrenia were randomly assigned receive either active sham cTBS...
Objective To investigate the developmental effects of clozapine and other atypical antipsychotics on infants who were exposed to as fetus. Method The progress 33 fetus was compared 30 risperidone, olanzapine or quetiapine by assessing Apgar scoring, birth weight at birth, body weight, height, Bayley Scales Infant Toddler Development, Third Edition (BSID-III) months 2, 6 12 age. Five subscale scores BSID-III including cognitive, language, motor, social-emotional, adaptive behavior also...
Abstract Background To explore the influence of CYP2D6 genetic polymorphism on risperidone metabolism, thereby affecting risperidone’s effects and safeties in patients with chronic schizophrenia. Methods Sixty-nine subjects schizophrenia treated were recruited. genotypes was determined using targeted sequencing translated into phenotype activity system. Risperidone plasma concentrations measured HPLC. Positive Negative Symptom Scale (PANSS) Brief Psychiatric Rating (BPRS) used to evaluate...
Second-generation antipsychotics are widely used to treat schizophrenia but their use could induce metabolic dysfunction. To balance efficacy and side effects, various guidelines recommend the of therapeutic drug monitoring. Given controversial relationship between olanzapine serum concentration dysfunction, its in clinical practice is still debated. address this issue, we conducted a prospective cohort study explore associations patients with schizophrenia. Specifically, first-episode...
This study aimed to evaluate the consistency or stability of mental disorders diagnosed in psychiatry ward setting, investigate factors associated with consistency, and observe disease distribution over decade.A total 20,359 psychiatric inpatients were included this retrospective from June 2011 December 2020. Diagnoses first admission discharge evaluated determine diagnostic during hospitalization. Readmissions selected as subgroup, whose last diagnoses compared analyze relatively long-term...
To determine associations between weight gain induced by antipsychotic and the polymorphisms of HTR2C gene -759C/T -697G/C, histamine-1 receptor gene, leptine -2548G/A, adiponectin +276G/T +45T/G.In case-matched study, 85 patients who gained more than 7% their pre-drug body served as study group another less control group. The ligation diction reaction technique was used to analyze frequencies -697G/C polymorphism -2548A/G leptin +45T/G glu349asp H1 gene.The presence -759C allele, -697G...
<b><i>Introduction:</i></b> Previous analysis showed that passive smoking and overweight were associated with an increased risk of gestational diabetes mellitus (GDM) in a synergistic manner, while GDM the macrosomia/large for age (LGA). This study aimed to examine any interactive effects between overweight/obesity on macrosomia/LGA. <b><i>Methods:</i></b> From 2010 2012, 22,302 pregnant women registered pregnancy at primary hospital Tianjin,...
Background: Cognitive impairment is one of the core symptoms schizophrenia, which considered to be significantly correlated prognosis. In recent years, many studies have suggested that metabolic disorders could related a higher risk cognitive defects in general setting. However, there has been limited evidence on association between metabolism and function patients with early-stage schizophrenia. Methods: this study, we recruited 172 Relevant parameters were examined was evaluated by using...
Bone resorption shows a circadian rhythm in human subjects, but the physiological mechanisms underlying this are unknown. We compared of bone collagen degradation 18 premenopausal women before and after oral calcium supplementation (1000 mg for 14 days). Subjects were randomized to receive at either 0800 h or 2300 h. Continuous 48-h urine collections 1 day 4-h obtained 14-day period. measured urinary deoxypyridinoline (Dpd) cross-linked N-telopeptide type I (NTx) as biochemical markers...