A5018193643- Genetics, Aging, and Longevity in Model Organisms
- Circadian rhythm and melatonin
- Genetic and Kidney Cyst Diseases
- Autophagy in Disease and Therapy
- Microtubule and mitosis dynamics
- Logic, Reasoning, and Knowledge
- Protein Kinase Regulation and GTPase Signaling
- Cellular transport and secretion
- Birth, Development, and Health
- Biomedical Research and Pathophysiology
- Orthopedic Infections and Treatments
- Hormonal Regulation and Hypertension
- Mitochondrial Function and Pathology
- Spaceflight effects on biology
- Orthopaedic implants and arthroplasty
- Logic, programming, and type systems
- Semantic Web and Ontologies
- Neuroinflammation and Neurodegeneration Mechanisms
- Immune cells in cancer
- Total Knee Arthroplasty Outcomes
- Biochemical and Molecular Research
- Endoplasmic Reticulum Stress and Disease
- Telomeres, Telomerase, and Senescence
- Hedgehog Signaling Pathway Studies
- Multi-Agent Systems and Negotiation
Center for Excellence in Molecular Cell Science
2003-2025
University of Chinese Academy of Sciences
2019-2025
Nantong University
2024-2025
Yancheng First People's Hospital
2024-2025
Chinese Academy of Sciences
2003-2024
Chongqing Medical University
2024
The Affiliated Yongchuan Hospital of Chongqing Medical University
2024
Chongqing Municipal Health Commission
2024
Fudan University
2023
Shanghai CASB Biotechnology (China)
2023
Gonads and Life Span Animals develop through successive life stages have spans that are determined by their genes the environment. Yet how molecular circuitry underlying life-stage structure relates to longevity is poorly understood. Shen et al. (p. 1472 ) now show components of a steroid receptor-microRNA switch used for Caenorhabditis elegans developmental timing co-opted regulate adult in response signals from reproductive system. Thus, gonad can be coupled metazoan span via clock.
Resource7 March 2022Open Access Transparent process Ageing induces tissue-specific transcriptomic changes in Caenorhabditis elegans Xueqing Wang orcid.org/0000-0003-3136-2568 State Key Laboratory of Cell Biology, Shanghai Institute Biochemistry and Center for Excellence Molecular Science, Chinese Academy Sciences, Shanghai, China University Beijing, Contribution: Resources, Data curation, Formal analysis, Validation, Investigation, Visualization, Methodology, Writing - original draft,...
Emerging evidence supports the idea that a signaling pathway containing orthologs of at least mammalian NudE and Nudel, Lis1, cytoplasmic dynein is conserved for eukaryotic nuclear migration. In mammals, this has profound impact on neuronal migration during development central nervous system. Lis1 are also involved in other cellular functions, such as mitosis. Here we show Nudel participates subset function M phase. was specifically phosphorylated phase its serine/threonine phosphorylation...
Dietary restriction (DR) extends lifespan in a wide variety of species, yet the underlying mechanisms are not well understood. Here we show that Caenorhabditis elegans HNF4α-related nuclear hormone receptor NHR-62 is required for metabolic and physiologic responses associated with DR-induced longevity. nhr-62 mediates longevity eat-2 mutants, genetic mimetic dietary restriction, blunts response DR induced by bacterial food dilution at low nutrient levels. Metabolic changes DR, including...
Abstract Macroautophagy, a key player in protein quality control, is proposed to be systematically impaired distinct tissues and causes coordinated disruption of homeostasis ageing throughout the body. Although tissue-specific changes autophagy have been extensively explored, mechanism underlying inter-tissue regulation with poorly understood. Here, we show that secreted microRNA, mir-83 /miR-29, controls age-related decrease macroautophagy across Caenorhabditis elegans . Upregulated...
Abstract Background Abnormal activation of microglia is involved in the pathogenesis schizophrenia. Minocycline and antipsychotics have been reported to be effective inhibiting thus alleviating negative symptoms patients with However, specific molecular mechanism by which minocycline inhibit microglial not clear. In this study, we aimed explore treatment effect on Methods Microglia cells were activated lipopolysaccharide (LPS) further treated minocycline, haloperidol, risperidone. Then cell...
Parkinson's disease (PD), one of the most devastating neurodegenerative brain disorders, is characterized by progressive loss dopaminergic neurons in substantia nigra (SN) and deposits α-synuclein aggregates. Currently, pharmacological interventions for PD remain inadequate. The cell necroptosis executor protein MLKL (Mixed-lineage kinase domain-like) involved various diseases, including inflammatory bowel diseases; however, its precise role remains unclear. Here, we investigated...
Abstract: Periprosthetic joint infection (PJI) is a catastrophic complication following replacement surgery, posing significant challenges to orthopedic surgeons. Due the lack of definitive diagnostic gold standard, timely treatment initiation problematic, resulting in substantial economic burdens on patients and society. In this review, we thoroughly analyze complexities PJI emphasize importance accurate diagnosis effective treatment. The article specifically focuses advancements...
Bile acids are cholesterol-derived signaling molecules that regulate mammalian metabolism through sterol-sensing nuclear receptor transcription factors. In C. elegans, bile acid-like steroids called dafachronic (DAs) control developmental timing and longevity by activating the DAF-12. However, little is known about biosynthesis of these molecules. Here, we show DAF-36/Rieske oxygenase works at first committed step, converting cholesterol to 7-dehydrocholesterol. Its elucidation as a...
Endogenous small molecule metabolites that regulate animal longevity are emerging as a novel means to influence health and life span. In C. elegans, bile acid-like steroids called the dafachronic acids (DAs) developmental timing through conserved nuclear hormone receptor DAF-12, homolog of mammalian sterol-regulated receptors LXR FXR. Using metabolic genetics, mass spectrometry, biochemical approaches, we identify new activities in DA biosynthesis characterize an evolutionarily short chain...
Food is critical for survival. Many animals, including the nematode <i>Caenorhabditis elegans</i>, use sensorimotor systems to detect and locate preferred food sources. However, signaling mechanisms underlying food-choice behaviors are poorly understood. Here, we characterize molecular that regulates recognition preference between different odors in <i>C. elegans</i>. We show major olfactory sensory neurons, AWB AWC, play essential roles this behavior. A canonical Gα-protein, together with...
Abstract Ageing exhibits common and distinct features in various tissues, making it critical to decipher the tissue-specific ageing mechanisms. MiRNAs are essential regulators recently highlighted as a class of intercellular messengers. However, little is known about transcriptomic changes miRNAs during ageing. C. elegans well-established model organism research. Here, we profile age-dependent miRNAomic five isolated worm tissues. Besides diverse ageing-regulated miRNA expression across...
Abstract In growing children, growth plate cartilage has limited self-repair ability upon fracture injury always leading to limb arrest. Interestingly, one type of injuries within the achieve amazing self-healing, however, mechanism is unclear. Using this mouse model, we discovered activation Hedgehog (Hh) signaling in injured plate, which could activate chondrocytes and promote repair. Primary cilia are central transduction mediator Hh signaling. Notably, ciliary Hh-Smo-Gli pathways were...
Axonal transport is critical for neuronal function and survival. Cytoplasmic dynein its accessory complex dynactin form a microtubule minus end‐directed motor in charge of retrograde transport. In this study, we show that Nudel, regulator, was highly expressed dorsal root ganglion (DRG) neurons. Microinjection anti‐Nudel antibody into cultured DRG neurons abolished membranous organelles the axon led to dispersions Golgi cisternae soma. As result, lysosomes, which are normally enriched soma,...
Muscle function relies on the precise architecture of dynamic contractile elements, which must be fine-tuned to maintain motility throughout life. is also plastic, and remodeled in response stress, growth, neural metabolic inputs. The conserved muscle-enriched microRNA, miR-1, regulates distinct aspects muscle development, but whether it plays a role during aging unknown. Here we investigated Caenorhabditis elegans miR-1 proteostatic stress. mir-1 deletion improved mid-life motility,...
Abstract Sensory perception and metabolic homeostasis are known to deteriorate with ageing, impairing the health of aged animals, while mechanisms underlying their deterioration remain poorly understood. The potential interplay between declining sensory impaired metabolism during ageing is also barely explored. Here, we report that intraflagellar transport (IFT) in cilia neurons nematode Caenorhabditis elegans due a daf-19 /RFX-modulated decrease IFT components. We find reduced thus impairs...
In a seminal paper, Gelfond and Lifschitz [34] introduced simple disjunctive logic programs, where in rule heads the disjunction operator "|" is used to express incomplete information, defined answer set semantics (called GL-semantics for short) based on program transformation GL-reduct) minimal model requirement. Our observations reveal that requirement of GL-semantics, i.e., an should be rules GL-reduct, may sometimes too strong condition exclude some sets would reasonably acceptable. To...