Abstract Drug delivery systems have become a research priority in the biomedical field. The incorporation of liposomes to hydrogels further forms more robust multifunctional for effective and sustained topical drug delivery. In this study, carboxymethyl‐modified chitosan/hyaluronic acid (CMC/HA, CMH) thermosensitive hydrogel is developed transdermal liposomes. Hydrogels are crosslinked by hydrogen bonding, hydrophobic interaction electrostatic interaction. gel properties can be regulated...

The regeneration of NAD(P)H and its analogues is crucial for biocatalytic processes. However, despite the efficiency enzymatic catalysis in regenerating NAD(P)H, sustainability enzymes often compromised, particularly under extreme catalytic conditions. Moreover, artificial cofactors may present advantages certain reactions due to their stability versatility, yet substrate specificity poses significant challenges through method. Therefore, it imperative develop a highly stable method that can...

Soundfield analysis based on spherical harmonic decomposition has been widely used in various applications; however, a drawback is the three-dimensional geometry of microphone arrays. In this paper, method to design two-dimensional planar arrays that are capable capturing (3D) spatial soundfields proposed. Through utilization both omni-directional and first order microphones, proposed array measuring soundfield components undetectable conventional arrays, thus providing same functionality as...

The application of pesticides is critical during the growth high-quality grape for wine making. However, pesticide residues have significant influence on flavor. In this study, gas chromatography-mass spectrometry (GC-MS) was performed and obtained datasets were analyzed with multivariate statistical methods to investigate changes in flavor substances fermentation. principal component analysis (PCA) score plot showed differences metabolites treated various pesticides. trials using five...

Allen and Berkley's image source method (ISM) is proven to be a very useful popular technique for simulating the acoustic room transfer function (RTF) in reverberant rooms. It based on assumption that receiver of interest are both omnidirectional. With inherent directional nature practical loudspeakers increasing use microphones, above often invalid. The main objective this paper generalize frequency domain ISM spherical harmonics such it could simulate RTF between transducers with...

A loudspeaker array is a key component in active noise cancellation (ANC) systems. Most in-car ANC systems utilize the car's own integrated loudspeakers to cancel due engine and other sources. In this paper, we evaluate loudspeakers' cancelling capabilities by analyzing field responses. We show that average power spatial region can be expressed using series of coefficients, decomposed into several basis patterns. Through analysing measurements car, built-in are capable attenuating driving up...

The direct-to-reverberant ratio (DRR), which describes the energy between direct and reverberant component of a soundfield, is an important parameter in many audio applications. In this paper, we present multichannel algorithm, utilizes blind recordings spherical microphone array to estimate DRR interest. algorithm developed based on spatial correlation model formulated harmonics domain. This expresses cross matrix recorded soundfield coefficients terms two matrices, one for sound other...

Liposome Hydrogels In article 2301933 by Ping Shao, Simin Feng, and co-workers, a carboxymethyl-modified chitosan/hyaluronic acid thermosensitive hydrogel dressing with good skin suitability is developed as an innovative solution for sustained transdermal delivery. This dressing, excellent compatibility, incorporates liposomes to combat UVA-induced photoaging. The liposome-hydrogel system acts versatile efficient delivery platform, enabling prolonged targeted

α-Arbutin is an effective skin-whitening cosmetic ingredient and hyperpigmentation therapy agent. It can be synthesized by one-step enzymatic glycosylation of hydroquinone (HQ), but limited the low yield. Amylosucrase (Amy-1) from Xanthomonas campestris pv. 8004 was recently identified with high HQ activity. In this study, whole-cell transformation Amy-1 optimized process scale-up evaluated in 5000-L reactor. comparison purified Amy-1, catalyst recombinant E. coli displays better tolerance...

The loudspeaker array plays a key role in an active noise cancellation (ANC) system. In most car ANC systems, the car's pre-installed multimedia loudspeakers are employed as secondary sources of this paper, we evaluate in-car system's capability multi-zone field by analyzing simultaneous at multiple control regions inside cabin. We show that average power spatial configurations can be expressed using series coefficients, and decomposed into several basis patterns. Based on model, also...

The localization of acoustic sound sources is beneficial to signal processing applications speech enhancement, dereverberation, separation and tracking. Difficulties in position estimation arise real world environments due coherent reflections degrading performance subspace techniques. This paper proposes a method multiple classification (MUSIC) localization, which suitable for reverberant rooms. based on the modal decomposition room's region-to-region transfer function, assumed be known. We...

Valinomycin is a cyclodepsipeptide antibiotic with broad spectrum of biological activities, such as antiviral, antitumor, and antifungal activities. However, the low yield valinomycin often limits its applications in medicine, agriculture, industry. In our previous report, Streptomyces sp. ZJUT-IFE-354 was identified high-yielding strain valinomycin. this study, Plackett-Burman design (PBD) response surface methodology (RSM) were used to optimize components medium. The optimal medium...

Cyclodextrin glycosyltransferase (CGTase) can catalyze the glycosylation of hesperidin, resulting in α-glycosyl hesperidin with significantly improved water solubility. In this study, a rational design CGTase to improve its activity was investigated. The strategy we employed involved docking near-attack conformation and virtually mutating surrounding residues, followed by calculating changes binding energy using Rosetta flex-ddG. mutations stabilization effect were then subjected an assay....

Dehydroepiandrosterone (DHEA) has a promising market due to its capacity regulate human hormone levels as well preventing and treating various diseases. We have established chemical esterification coupled biocatalytic-based scheme by lipase-catalyzed 4-androstene-3,17-dione (4-AD) hydrolysis obtain the intermediate product 5-androstene-3,17-dione (5-AD), which was then asymmetrically reduced ketoreductase from Sphingomonas wittichii (SwiKR). Co-enzyme required for KR is regenerated glucose...