A5027815446- Gestational Diabetes Research and Management
- Bariatric Surgery and Outcomes
- Birth, Development, and Health
- Pregnancy and preeclampsia studies
- Obesity, Physical Activity, Diet
- Adipokines, Inflammation, and Metabolic Diseases
- Diabetes, Cardiovascular Risks, and Lipoproteins
- Nutritional Studies and Diet
- Obesity and Health Practices
- Cardiovascular Disease and Adiposity
- Health disparities and outcomes
- Folate and B Vitamins Research
- Sleep and Work-Related Fatigue
- Liver Disease Diagnosis and Treatment
- Lipid metabolism and disorders
- Phytoestrogen effects and research
- Adipose Tissue and Metabolism
- Physical Activity and Health
- Diabetes Management and Education
- Fatty Acid Research and Health
- Diet and metabolism studies
- Pregnancy-related medical research
- Diet, Metabolism, and Disease
- Gut microbiota and health
- Environmental Justice and Health Disparities
Dalhousie University
2016-2025
Community Health Center
2024
Anhui Polytechnic University
2024
McMaster University
2019-2023
Xinjiang University
2018
Tianjin Children's Hospital
2017
Brock University
2012-2014
Shanghai Institutes for Biological Sciences
2007-2012
Chinese Academy of Sciences
2007-2012
Institute for Biological Sciences
2008-2010
OBJECTIVE To evaluate the association between 25-hydroxyvitamin D [25(OH)D] and metabolic syndrome in Chinese population. RESEARCH DESIGN AND METHODS Plasma 25(OH)D was measured a cross-sectional sample of 1,443 men 1,819 women aged 50–70 years from Beijing Shanghai. Metabolic defined according to updated National Cholesterol Education Program Adult Treatment Panel III criteria for Asian Americans. Fasting plasma glucose, insulin, lipid profile, A1C, inflammatory markers were measured....
OBJECTIVE Elevated lipopolysaccharide-binding protein (LBP), a marker of subclinical endotoxemia, may be involved in the pathogenesis obesity and metabolic risk. We aimed to investigate association between plasma LBP disorders apparently healthy Chinese. RESEARCH DESIGN AND METHODS A population-based study including 559 overweight/obese (BMI ≥24.0 kg/m2) 500 normal-weight (18.0 ≤ BMI <24.0 subjects aged 35–54 years was conducted Shanghai, China. Fasting glucose, lipid profile, LBP,...
We compared the increases in prevalence of gestational diabetes mellitus (GDM) based on 1999 World Health Organization (WHO) criteria and its risk factors Tianjin, China, over a 12-year period. also examined changes using International Association Diabetes Pregnancy Study Group (IADPSG).In 2010-2012, 18589 women who registered within 12 weeks gestation underwent glucose challenge test (GCT) at 24-28 weeks. Amongst them, 2953 with 1-hour plasma ≥ 7.8 mmol/L 75-gram 2-hour oral tolerance...
Genome-wide association studies have identified common variants in CDKAL1, CDKN2A/B, IGF2BP2, SLC30A8, HHEX/IDE, EXT2, and LOC387761 loci that significantly increase the risk of type 2 diabetes. We aimed to replicate these observations a population-based cohort Chinese Hans examine associations with diabetes diabetes-related phenotypes.We genotyped 17 single nucleotide polymorhisms (SNPs) 3,210 unrelated Hans, including 424 participants diabetes, 878 impaired fasting glucose (IFG), 1,908...
High retinol-binding protein 4 (RBP4) is thought to be associated with insulin resistance in humans. However, evidence from large-scale populations about the relationship between RBP4 and metabolic diseases scarce.We evaluated plasma distribution its association syndrome (MetS) among middle-aged older Chinese.We a cross-sectional sample of 3289 Chinese aged 50 70 yr Beijing Shanghai by using an in-house developed validated sandwich ELISA. MetS was defined according updated National...
Context: Elevated ferritin concentrations frequently cluster with well-established risk factors of diabetes including obesity, metabolic syndrome, chronic inflammation, and altered circulating adipokines. Few studies, however, have systematically evaluated the effect these on ferritin-diabetes association, particularly in Chinese populations. Objective: We aimed to investigate, a middle-aged elderly population, whether elevated are associated higher syndrome type 2 what extent associations...
Diabet. Med. 28, 652–657 (2011) Abstract Aims To investigate the trend in prevalence of gestational diabetes mellitus during 1999–2008 women living urban Tianjin, China. Methods A universal screening for has become an integral part antenatal care China from 1998. total 105 473 pregnant six districts China, participated programme between December 1998 and 2008. The test consisted a 50‐g 1‐h glucose test. Women who had reading ≥ 7.8 mmol/l at initial were invited to undergo standard 2‐h oral...
Flaxseed consumption has been shown to improve blood lipids in humans and flaxseed-derived lignan enhance glycemic control animals. The study aimed investigate the effect of a supplement on control, lipid profiles insulin sensitivity type 2 diabetic patients.This was randomized, double-blind, placebo-controlled, cross-over trial it conducted between April December 2006 Shanghai, China. Seventy-three patients with mild hypercholesterolemia were enrolled into study. Patients randomized...
Inflammatory factors, adipocytokines, and the metabolic syndrome are important determinants of cardiometabolic disease. It remains unclear how physical activity is related to these risk factors. Our objective was investigate single joint associations with inflammatory among middle-aged older Chinese people.A total 3289 individuals (1458 men, 1831 women) 50 70 years age participated in a population-based cross-sectional survey Beijing Shanghai, China. Levels were assessed International...
Few studies assessed effects of individual and multiple ions simultaneously on metabolic outcomes, due to methodological limitation.By combining advanced ionomics mutual information, a quantifying measurement for dependence between two random variables, we investigated associations ion modules/networks with overweight/obesity, syndrome (MetS) type 2 diabetes (T2DM) in 976 middle-aged Chinese men women. Fasting plasma were measured by inductively coupled mass spectroscopy. Significant modules...
Abstract Aims To examine the association between sleep disturbances during pregnancy and risk of gestational diabetes mellitus. Methods From 2010 to 2012, 12 506 women in Tianjin, China, were screened using a 50‐g 1‐h glucose challenge test at 24–28 weeks’ gestation. Those with values ≥ 7.8 mmol/l invited further undergo 75‐g 2‐h oral tolerance test. Gestational was determined according International Association Diabetes Pregnancy Study Group's definition. Self‐reported duration quality...
There are no randomised controlled trials to demonstrate whether lifestyle modifications can improve pregnancy outcomes of gestational diabetes mellitus (GDM) diagnosed by the International Association Diabetes and Pregnancy Study Group's (IADPSG) criteria. We tested effectiveness implemented in a 3-tier's shared care (SC) on GDM.
This study aimed to develop a machine learning-based prediction model for gestational diabetes mellitus (GDM) in early pregnancy Chinese women.We used an established population-based prospective cohort of 19,331 pregnant women registered as before the 15th week Tianjin, China, from October 2010 August 2012. The dataset was randomly divided into training set (70%) and test (30%). Risk factors collected at registration were examined construct dataset. Machine learning, that is, extreme...
Elevated C-reactive protein (CRP), IL-6 and retinol-binding 4 (RBP4) levels are associated with insulin resistance diabetes mellitus. Phytoestrogens (including lignans isoflavones) may enhance the management of hypothesized to act through inflammation pathways. The present study explored effects flaxseed-derived lignan on inflammatory factors RBP4 concentrations in type 2 diabetics, who have higher these biomarkers. Seventy community-dwelling diabetic patients (twenty-six men forty-four...
Abstract Background Self-rated health (SRH) has been demonstrated to be an accurate reflection of a person's and valid predictor incident mortality chronic morbidity. We aimed evaluate the distribution factors associated with SRH its association biomarkers cardio-metabolic diseases among middle-aged elderly Chinese. Methods Survey 1,458 men 1,831 women aged 50 70 years, conducted in one urban two rural areas Beijing Shanghai 2005. status was measured categorized as good (very good) vs. not...
Objective To evaluate the effects of prepregnancy BMI and weight change from to postpartum on type 2 diabetes (T2D) risk among women with gestational (GDM). Methods A retrospective cohort study in 1,263 GDM at 1-5 years after delivery was performed. Cox proportional hazards regression models were used association T2D prediabetes risks. Results The multivariable-adjusted hazard ratios based different levels (<23, 23-24.9, 25-29.9, ≥30 kg/m2) 1.00, 1.77, 2.35, 6.54 (Ptrend < 0.001) for...
To examine the relative contributions of β-cell dysfunction and insulin resistance to postpartum diabetes risk among obese nonobese women with prior gestational mellitus (GDM).We performed a cross-sectional survey 1-5 years after 1,263 who had GDM gave birth. Polytomous logistic regression models were used assess associations (the lower quartile HOMA-%β), upper HOMA-IR), decreased sensitivity HOMA-%S), different categories BMI prediabetes risk.β-Cell dysfunction, resistance, all...