A5068808118- Traditional Chinese Medicine Analysis
- Natural product bioactivities and synthesis
- Metabolomics and Mass Spectrometry Studies
- Phytochemistry and Biological Activities
- Ginseng Biological Effects and Applications
- Neurological Disease Mechanisms and Treatments
- Plant-based Medicinal Research
- Ginkgo biloba and Cashew Applications
- Analytical Chemistry and Chromatography
- Chromatography in Natural Products
- Plant biochemistry and biosynthesis
- Phytochemicals and Antioxidant Activities
- Traditional Chinese Medicine Studies
- Medicinal Plants and Neuroprotection
- Botanical Studies and Applications
- Phytochemical and Pharmacological Studies
- Microbial Metabolism and Applications
- Pharmacological Effects of Natural Compounds
- Pregnancy and preeclampsia studies
- Medicinal Plant Pharmacodynamics Research
- Essential Oils and Antimicrobial Activity
- Gestational Diabetes Research and Management
- Medicinal plant effects and applications
- Mass Spectrometry Techniques and Applications
- Ionic liquids properties and applications
China Pharmaceutical University
2016-2025
Guangdong Ocean University
2022-2024
Beijing Chao-Yang Hospital
2020-2024
Capital Medical University
2013-2024
Kyoto University
2024
Tianjin University of Science and Technology
2010-2024
Kyoto Pharmaceutical University
2024
Shanghai Clinical Research Center
2023
Huadong Hospital
2023
Fudan University
2023
Diabet. Med. 28, 652–657 (2011) Abstract Aims To investigate the trend in prevalence of gestational diabetes mellitus during 1999–2008 women living urban Tianjin, China. Methods A universal screening for has become an integral part antenatal care China from 1998. total 105 473 pregnant six districts China, participated programme between December 1998 and 2008. The test consisted a 50‐g 1‐h glucose test. Women who had reading ≥ 7.8 mmol/l at initial were invited to undergo standard 2‐h oral...
Ginkgo biloba is one of the oldest extant seed plants and has a number unique properties uses. Numerous efforts have characterized metabolites within ginkgo plant their corresponding biosynthesis pathways, but spatio-chemical information on lacking. Mass spectrometry (MS) imaging was used to interrogate localization with matrix-assisted laser desorption/ionization Fourier-transform ion cyclotron resonance MS across leaf. Flavonoids, particularly unexpected rare flavonoid cyclodimers, were...
Background and Purpose Non‐alcoholic steatohepatitis (NASH) is the most severe form of non‐alcoholic fatty liver disease a serious public health problem around world. There are currently no approved treatments for NASH. FGF21 has recently emerged as promising drug candidate metabolic diseases. However, disadvantages clinically useful medicine include its short plasma half‐life poor drug‐like properties. Here, we have explored effects PsTag600‐FGF21, an engineered long‐acting fusion protein,...
The metabolism of activated macrophages relies on aerobic glycolysis, while mitochondrial oxidation is disrupted. In lipopolysaccharide-activated macrophages, the citrate carrier (CIC) exports from mitochondria to enhance glycolytic genes through histone acetylation. CIC inhibition or Slc25a1 knockdown reduces occupancy H3K9ac hypoxia-inducible factor-1α (HIF-1α) binding sites in promoters restrain glycolysis. HIF-1α also transcriptionally upregulates immune-responsive gene 1 for itaconate...
Total ethanol extract and saponins from Chinese herb Radix Astragali (Huangqi) have been previously shown to possess anti-hepatitis B virus (HBV) activities in vitro. To identify the active ingredients, we isolated a triterpenoid saponin that was determined be astragaloside IV. In human HBV-transfected liver cell line HepG2 2.2.15, IV effectively suppressed secretion of HBV antigens with inhibition rates 23.6% for Hepatitis surface antigen (HBsAg) 22.9% e (HBeAg) at 100 μg/ml after 9 d...
Rowan, J.A.; Hague, W.M.; Gao, W.; Battin, M.R.; Moore, M.P. MiG Trial Investigators Author Information
In the area of image retrieval, post-retrieval processing is often used to refine retrieval results better satisfy users' requirements. Previous methods mainly focus on presenting users with relevant results. However, in most cases, cannot clearly present their requirements by several query words. Therefore, rich topic coverage are more likely meet ambiguous needs. this paper, a re-ranking method based richness analysis proposed enrich Furthermore, quantitative criterion called diversity...
Radix Astragali (Astragalus) has been used in Traditional Chinese Medicine for over 2000 years, and still widely Asian countries to enhance the immune system protect body against various stresses. In Europe United States, Astragalus is commonly as nutritional dietary supplements additives foods beverages. During last several we have witnessed a steady expansion number of publications made associated with this herb. This review focuses on latest advancements trends chemistry, analysis,...
Summary Lonicera macranthoides (LM) and L. japonica (LJ) are medicinal plants widely used in treating viral diseases, such as COVID‐19. Although the two species morphologically similar, their secondary metabolite profiles significantly different. Here, metabolomics analysis showed that LM contained ~86.01 mg/g hederagenin‐based saponins, 2000‐fold higher than LJ. To gain molecular insights into its production, a chromosome‐level genome of was constructed, comprising 9 pseudo‐chromosomes with...
Abstract Background Cell membrane chromatography (CMC) is a biochromatography with dual function of recognition and separation, offering distinct advantage in screening bioactive compounds from Chinese medicines (CMs). Yindan Xinnaotong soft capsule (YD), CM formulation, has been widely utilized the treatment cardiovascular disease. However, comprehensive mapping myocardial protective active remains elusive. Purpose To establish stable efficient 2D H9c2/CMC-RPLC-MS system, to utilize it for...
Background: Neuroinflammation has been proven as a significant factor linked to stroke, with NLRP3 inflammasome activation being common neuroinflammatory manifestation. Microtubule affinity regulating kinase 4 (MARK4) plays crucial role in the activation. However, impact of MARK4 on neuroinflammation stroke remains inadequately understood.Objective: To elucidate effects and underlying mechanisms microglial inflammasome, identify antagonists from safflower (the flower Carthamus tinctorius...
Fibrosis can damage the normal function of many organs, such as cardiac function, for which no effective clinical therapies exist. However, traditional approaches to anti-fibrosis drug discovery have primarily focused on final biological indicators, often overlooking dynamic morphological changes during fibrosis progression. Here, we present a novel approach, deep-DPC, integrates label-free, time-series digital phase contrast (DPC) imaging with cell morphology analysis and unsupervised...
Although the role of WRKY transcription factors (TFs) in colour formation has been reported several species, their function potato (Solanum tuberosum L.) anthocyanin biosynthesis remains unclear. In this study, gene StWRKY13 was isolated and characterised. Expression analysis revealed a significantly higher expression chromatic tubers than yellow ones. Transient activation assays showed that could enhance StAN2 promoting tobacco (Nicotiana tabacum L.). Over-expressing promoted tubers....