A5100341983- Cancer-related molecular mechanisms research
- Prostate Cancer Treatment and Research
- Prostate Cancer Diagnosis and Treatment
- Maritime Ports and Logistics
- Pancreatic and Hepatic Oncology Research
- MicroRNA in disease regulation
- Circular RNAs in diseases
- Epigenetics and DNA Methylation
- Plant Molecular Biology Research
- Hedgehog Signaling Pathway Studies
- Cancer Research and Treatments
- Adipokines, Inflammation, and Metabolic Diseases
- Lung Cancer Diagnosis and Treatment
- Global Cancer Incidence and Screening
- RNA and protein synthesis mechanisms
- Nutrition and Health in Aging
- Gastric Cancer Management and Outcomes
- RNA Research and Splicing
- RNA modifications and cancer
- Pancreatitis Pathology and Treatment
- Colorectal Cancer Screening and Detection
- Smart Grid Energy Management
- Liver Disease Diagnosis and Treatment
- Cancer, Hypoxia, and Metabolism
- Plant Reproductive Biology
Changhai Hospital
2011-2025
Dalian University of Technology
2024-2025
Second Military Medical University
2011-2025
Zhejiang University
2023-2025
Dalian Medical University
2022-2025
Chongqing Medical University
2022-2025
Second Affiliated Hospital of Chongqing Medical University
2022-2025
Qingdao University
2023-2025
Peking University
2025
Fudan University
2024-2025
OBJECTIVE Elevated lipopolysaccharide-binding protein (LBP), a marker of subclinical endotoxemia, may be involved in the pathogenesis obesity and metabolic risk. We aimed to investigate association between plasma LBP disorders apparently healthy Chinese. RESEARCH DESIGN AND METHODS A population-based study including 559 overweight/obese (BMI ≥24.0 kg/m2) 500 normal-weight (18.0 ≤ BMI <24.0 subjects aged 35–54 years was conducted Shanghai, China. Fasting glucose, lipid profile, LBP,...
No AccessJournal of UrologyCLINICAL UROLOGY: Original Articles1 May 2003Pretreatment Total Testosterone Level Predicts Pathological Stage in Patients With Localized Prostate Cancer Treated Radical Prostatectomy JASON C. MASSENGILL, LEON SUN, JUDD W. MOUL, HONGYU WU, DAVID G. McLEOD, CHRISTOPHER AMLING, RAYMOND LANCE, JOHN FOLEY, WADE SEXTON, LEO KUSUDA, ANDREW CHUNG, DOUGLAS SODERDAHL, and TIMOTHY DONAHUE MASSENGILLJASON MASSENGILL More articles by this author , SUNLEON SUN MOULJUDD MOUL...
Hormonal therapy (HT) is the current mainstay of systemic treatment for prostate specific antigen (PSA) only recurrence (PSAR), however, there virtually no published literature comparing HT to observation in clinical setting. The goal this study was examine Department Defense Center Prostate Disease Research observational database compare outcomes men who experienced PSAR after radical prostatectomy by early versus delayed use and a risk stratified approach.Of 5,382 underwent primary (RP),...
No AccessJournal of UrologyCLINICAL UROLOGY: Original Articles1 Mar 2004Early Versus Delayed Hormonal Therapy for Prostate Specific Antigen Only Recurrence Cancer After Radical Prostatectomyis companion ofEarly Prostatectomy JUDD W. MOUL, HONGYU WU, LEON SUN, DAVID G. McLEOD, CHRISTOPHER AMLING, TIMOTHY DONAHUE, LEO KUSUDA, WADE SEXTON, KEITH O'REILLY, JAVIER HERNANDEZ, ANDREW CHUNG, and DOUGLAS SODERDAHL MOULJUDD MOUL , WUHONGYU WU SUNLEON SUN McLEODDAVID McLEOD AMLINGCHRISTOPHER AMLING...
Higher intake of whole grains has been associated with a lower risk major chronic diseases, such as type 2 diabetes mellitus and cardiovascular disease (CVD), although limited prospective evidence exists regarding grains' association mortality.To examine the between dietary grain consumption mortality.We investigated 74 341 women from Nurses' Health Study (1984-2010) 43 744 men Professionals Follow-Up (1986-2010), large cohort studies. All patients were free CVD cancer at baseline.Hazard...
Objectives: Rare pathogenic variants in the SPINK1, PRSS1, CTRC, and CFTR genes have been strongly associated with a risk of developing chronic pancreatitis (CP). However, their potential impact on age disease onset clinical outcomes, as well interactions environmental factors, remain unclear. These issues are addressed here large Chinese CP cohort. Methods: We performed targeted next-generation sequencing four CP-associated 1061 Han patients 1196 controls. To evaluate gene-environment...
The incidence of ulcerative colitis (UC) is increasing annually, and UC has a serious impact on patients’ lives. Polysaccharides have gained attention as potential drug candidates for treating in recent years. Huaier (Trametes robiniophila Murr) fungus that been used clinically more than 1000 years, its bioactive polysaccharide components reported to possess immunomodulatory effects, antitumour potential, renoprotective effects. In this study, we aimed examine the protective effects...
Ankylosing spondylitis (AS) is a systemic chronic inflammatory disease. Andersson lesion (AL) late complication of advanced AS. Idiopathic spinal cord hernia (ISCH) rare disorder the cord. However, according to our literature review, simultaneous occurrence AL together with ISCH in single AS patient had never been reported. A 49-year-old male reported 30-year history thoracolumbar pain and limited mobility was diagnosed dual complications ICSH. Before correction surgery, physical...
ABSTRACT Imaging‐guided phototherapy holds promise for precision cancer treatment. However, most photosensitizers have only a singular modality of photodynamic therapy (PDT) or photothermal (PTT), which make their therapeutic efficacy severely limited by the hypoxic and complex tumor microenvironment (TME). In this article, we provide smart platform design (BOD‐D) based on visualized light‐triggered phototherapeutic switch transforming from near‐infrared (NIR)‐I imaging‐guided PDT to...
Abstract The U.S. active-duty military population may differ from the general in its exposure to cancer risk factors and access medical care. Yet, it is not known if incidence rates between these two populations. We therefore compared of four cancers common adults (lung, colorectal, prostate, breast cancers) more young (testicular cervical Data Automated Central Tumor Registry (ACTUR) Department Defense nine registries Surveillance, Epidemiology End Results (SEER) National Cancer Institute...
The mammalian collecting duct comprises principal and intercalated cells, which maintain sodium/water acid/base balance, respectively, but the epigenetic contributors to differentiation of these cell types remain unknown. Here, we investigated whether histone H3 K79 methyltransferase Dot1l, is highly expressed in participates this process. Taking advantage distribution aquaporin 2 (Aqp2), localizes cells duct, developed mice lacking Dot1l Aqp2-expressing (Dot1lAC) found that had...
GRAS transcriptional factors have diverse functions in plant growth and development, are named after the first three transcription factors, namely, GAI (GIBBERELLIC ACID INSENSITIVE), RGA (REPRESSOR OF GAI) SCR (SCARECROW) identified this family. Knowledge of gene family maize remains was largely unknown, their characterization is necessary to understand importance life cycle. This study 86 genes maize, further characterized with phylogenetics, structural analysis, genomic loci, expression...
Associations of overall and regional body fat measured by dual-energy X-ray absorptiometry with total cause-specific mortality in the National Health Nutrition Examination Survey (NHANES) 1999-2006 were investigated.This study included 9,471 participants (≥20 years) free major chronic diseases at baseline. Death information was obtained from Index (mean follow-up duration: 8.8 years).A 682 died after 12 months since baseline, 206 170 deaths attributed to cardiovascular (CVD) cancer,...
As an important complication of diabetes mellitus, diabetic cardiomyopathy (DCM) is characterized by a silent development in its earlier stage and deficient cardiomyocyte contractility late stage. So far, little advance has been achieved to reverse this pathological change. LncRNAs are defined as large cluster RNAs without the function encoding proteins, but have capacity controlling gene expression. Interleukin-17 (IL-17), proinflammatory cytokine, key regulator host inflammation....
Previous studies reported that patients with preexisting radiological interstitial lung abnormalities (ILAs) were more susceptible to developing radiation pneumonitis (RP) after thoracic therapy (TRT). The present study aimed evaluate the incidence and predictors of RP TRT in small-cell cancer (SCLC) or without ILAs.A total 95 consecutive SCLC between January 2015 December 2015, who treated intensity-modulated at Shanghai Pulmonary Hospital,Tongji University School Medicine, analyzed....
One major reason for the failure of advanced colorectal cancer (CRC) treatment is occurrence chemoresistance to fluoropyrimidine (Fu)-based chemotherapy. Accumulating evidence indicates that long non-coding RNAs (lncRNAs) play a critical role in cancerous processes as either oncogenes or tumor suppressor genes. Here, we observed lncRNA TUG1 was associated 5-Fu resistance cancer. Firstly, quantitative analysis indicated significantly increased recurrence CRC patient samples. Kaplan-Meier...
Abstract Resistance of chemotherapy is one causes recurrence and poor prognosis in patients with colorectal cancer (CRC). The role differentially expressed long non-coding RNA (lncRNA) 5-fluorouracil (5-Fu) resistance has not been fully elucidated. Here we observed that lncRNA NEAT1 was associated 5-Fu CRC. Our Functional studies showed promoted cells. In addition, A-TAC sequencing chromatin immunoprecipitation (ChIP) affected remodeling, increased the acetylation levels histones, their...
Abstract Prunus species include many important perennial fruit crops, such as peach, plum, apricot, and related wild species. Here, we report de novo genome assemblies for five species, including the cultivated peach ( persica ), plum salicina apricot armeniaca Tibetan mira ) Chinese davidiana ). The genomes ranged from 240 to 276 Mb in size, with contig N50 values of 2.27−8.30 25,333−27,826 protein-coding gene models. As phylogenetic tree shows, diverged its common ancestor ~7 million years...
This study used three-stage data envelopment analysis (DEA) and Tobit regression models to comprehensively evaluate the performance levels, trends, differences of marine ecological welfare (MEW) in China, explore its influencing factors derive relevant policy suggestions. The evaluation results indicate that DEA model performed better on MEW than traditional by effectively eliminating influence random errors external environmental factors. However, it underestimated coastal country. southern...