Cancer-associated fibroblasts (CAFs) function as a crucial factor in tumor progression by carrying exosomes to neighboring cells. This study was assigned expound the underlying mechanism of CAFs-derived exosomal miR-210 non-small cell lung cancer (NSCLC) progression. CAFs and normal (NFs) were isolated identified. Exosomes secreted from NFs analyze their effects on volume epithelial-mesenchymal transition (EMT). Exosomal expression level measured. The UPF1 viability, EMT, PTEN/PI3K/AKT...

Abstract Objective Non-small cell lung cancer (NSCLC) often exhibits resistance to radiotherapy, posing significant treatment challenges. This study investigates the role of SMAD3 in NSCLC, focusing on its potential influencing radiosensitivity via ITGA6/PI3K/Akt pathway. Methods The utilized gene expression data from GEO database identify differentially expressed genes related radiotherapy NSCLC. Using GSE37745 dataset, prognostic were identified through Cox regression and survival...

One major reason for the failure of advanced colorectal cancer (CRC) treatment is occurrence chemoresistance to fluoropyrimidine (Fu)-based chemotherapy. Accumulating evidence indicates that long non-coding RNAs (lncRNAs) play a critical role in cancerous processes as either oncogenes or tumor suppressor genes. Here, we observed lncRNA TUG1 was associated 5-Fu resistance cancer. Firstly, quantitative analysis indicated significantly increased recurrence CRC patient samples. Kaplan-Meier...

number is SRX249046).

Our study aimed to explore the effects of long noncoding RNA (lncRNA)-ANCR on invasion and migration colorectal cancer (CRC) cells by regulating enhancer zeste homolog 2 (EZH2) expression. CRC tissues adjacent normal were collected SW620 line human int estinal epithelial (HIECs) incubated. was transfected with ANCR-siRNA. The expressions ANCR EZH2 mRNA measured real-time quantitative polymerase chain reaction (RT-qPCR). trimethylation H3K27 (H3K27me3) protein detected using Western blotting....

Triple-negative breast cancer (TNBC) is a particular subtype with poor prognosis due to its aggressive biological behavior and lack of targets for therapy. This study aimed explore the expression profile potential function lncRNAs in TNBC through bioinformatic methods.Two microarrays were obtained from Gene Expression Omnibus database. Differentially expressed mRNAs screened out expressions top overlapping validated using data The Cancer Genome Atlas co-expression analysis was conducted R...

Abstract Aberrant lipid metabolism has recently been recognized as a new hallmark of malignancy, but the characteristics fatty acid in breast cancer stem cells (BCSC) and potential interventions targeting this pathway remain to be addressed. Here, by using vitro BCSC models, mammosphere-derived MCF-7 HMLE-Twist-ER cells, we found that with cell-like properties exhibited very distinct profile compared their parental characterized increased lipogenesis, especially activity stearoyl-CoA...

Despite great advances in the treatment of liver hepatocellular carcinoma (LIHC), such as immunotherapy, prognosis remains extremely poor, and there is an urgent need to develop novel diagnostic prognostic markers. Recently, RNA methylation-related long non-coding RNAs (lncRNAs) have been demonstrated be potential biomarkers for tumor diagnosis well immunotherapy response, N6-methyladenine (m6A) 5-methylcytosine (m5C). N7-Methylguanosine (m7G) a widespread modification eukaryotes, but...

This study aimed to explore the correlation between proton density fat fraction (PDFF) of infrapatellar pad and severity knee osteoarthritis (KOA), with a focus on identifying potential imaging biomarkers for KOA progression. Seventy patients forty-four healthy controls (HCs) were prospectively recruited conventional MR mDIXON-Quant sequence scanning. The technique was selected its precision in quantification ability provide three-dimensional water-fat separation, offering superior accuracy...

C-X-C chemokine receptor type 4 (CXCR4) plays an important role in determining the metastatic potential of non-small cell lung cancer. In order to elucidate effect and mechanism CXCR4 tumor angiogenesis we evaluated clinical significance CXCR4, phosphorylated signal transducer activator transcription 3 (P-STAT3), vascular endothelial growth factor (VEGF) expression patients with completely resected cancer (NSCLC). A total 208 cases NSCLC were collected, P-STAT3 VEGF-A tissue was investigated...

Lung adenocarcinoma (LUAD) poses a significant threat to public health worldwide, while the genetic and epigenetic abnormalities involved in oncogenesis of LUAD remains unknown. This study aimed identify validate key genes during development progression by multiomics analysis. First, Empirical Analysis Digital Gene Expression Data R (EdgeR) was used differentially regulated between normal samples samples. Then significance analysis microarrays (SAM) methylated microRNAs (miRNAs) Following...

Abstract Background LncRNA MEG3 expressed abnormally in various cancers including breast cancer, but no studies reported the correlation between SNPs and cancer susceptibility among Chinese women. Methods This study is aimed to explore association three of (rs3087918, rs7158663, rs11160608) cancer. The a population-based case-control 434 patients 700 healthy controls. Genotyping was performed using Sequenom MassArray technique. Function prediction rs3087918 were based on RNAfold lncRNASNP2...

Abnormal metabolism, including abnormal fatty acid is an emerging hallmark of cancer. The current study sought to investigate the potential prognostic value metabolism-related long noncoding RNAs (lncRNAs) in colorectal cancer (CRC). To this end, we obtained gene expression data and clinical patients with CRC from Cancer Genome Atlas (TCGA) database. Through set variation analysis (GSVA), found that metabolism pathway was related stage prognosis CRC. After screening differentially expressed...

Soft tissue sarcomas (STSs) are rare, heterogeneous mesenchymal neoplasias. Understanding the tumor microenvironment (TME) and identifying potential biomarkers for prognosis associated with TME of STS might provide effective clues immune therapy. We evaluated scores stromal patients by using RNA sequencing dataset from The Cancer Genome Atlas (TCGA) database ESTIMATE algorithm. Then, differentially expressed mRNAs (DEGs), miRNAs (DEMs) lncRNAs (DELs) were identified after comparing high-...

Abstract Background Aberrant DNA methylation is an epigenetic marker that has been linked to the pathogenesis of colorectal cancer (CRC). Long noncoding RNAs (lncRNAs) have increasingly identified be associated with tumorigenic processes CRC. Identifying epigenetically dysregulated lncRNAs and characterizing their effects during carcinogenesis are focuses research. Methods Differentially methylated loci expressed were by integrating methylome transcriptome analyses using The Cancer Genome...

Audio-Visual Video Parsing is a task to predict the events that occur in video segments for each modality. It often performs weakly supervised manner, where only event labels are provided, i.e., modalities and timestamps of unknown. Due lack densely annotated labels, recent work attempts leverage pseudo enrich supervision. A commonly used strategy generate by categorizing known However, still limited level, temporal boundaries remain unlabeled. In this paper, we propose new label generation...

Background: Forkhead box P3 ( FOXP3 ) is a key gene in the immune system which also plays role tumor development. This study aims to explore association of two polymorphisms (rs3761548 and rs3761549) with susceptibility breast cancer (BC). Method: A case–control was conducted, involving 560 patients 583 healthy individuals from Chinese Han population. The genotypes were detected using Sequenom MassARRAY method. between BC risk evaluated χ2 test an odds ratio (OR) 95% confidence intervals...

Long non-coding RNAs (lncRNAs) have been reported to be vital participants in tumor progression.Recently, lncRNA PSMB8-AS1 has uncovered facilitate pancreatic cancer progression by regulating miR-382-3p/STAT1/PD-L1 network.Nonetheless, the role of and its underlying mechanism not well-explored colorectal (CRC).The expression or proteins was detected via qRT-PCR western blot assays.Functional assays were involved evaluating effects PSMB8-AS1/miR-1299/ADAMTS5 on malignant behaviors CRC...

Growing oocytes acquire the ability to mature through two-way communication between gametes and surrounding somatic cumulus cells (CCs). Granulosa (GCs) support oocyte growth, regulate meiosis progression, modulate global transcription activity. However, proliferation differentiation of yak ovary in GCs CCs remain unclear. To characterize important roles long non-coding RNA, (lncRNA), microRNA (miRNA), messenger RNA (mRNA), whole-transcriptome analysis was performed. Real-time quantitative...