A5101554832- Cancer-related molecular mechanisms research
- RNA modifications and cancer
- Genomics and Chromatin Dynamics
- Energy and Environment Impacts
- Circular RNAs in diseases
- Epigenetics and DNA Methylation
- Climate Change and Health Impacts
- RNA Research and Splicing
- Gene expression and cancer classification
- Bioinformatics and Genomic Networks
- Air Quality and Health Impacts
- Cancer Genomics and Diagnostics
- MicroRNA in disease regulation
- DNA Repair Mechanisms
- Lung Cancer Research Studies
- Cholangiocarcinoma and Gallbladder Cancer Studies
- Chronic Kidney Disease and Diabetes
- ATP Synthase and ATPases Research
- Plant Surface Properties and Treatments
- Cancer therapeutics and mechanisms
- Genomic variations and chromosomal abnormalities
- Plant and Fungal Interactions Research
- Cancer Cells and Metastasis
- PI3K/AKT/mTOR signaling in cancer
- Chemokine receptors and signaling
China Pharmaceutical University
2024
Eastern Hepatobiliary Surgery Hospital
2021-2024
Second Military Medical University
2021-2024
Second Affiliated Hospital of Xi'an Jiaotong University
2016-2022
Northwest A&F University
2022
International Institute for Applied Systems Analysis
2022
Peking University
2022
Zhejiang University
2020-2021
First Affiliated Hospital Zhejiang University
2020
First People's Hospital of Yunnan Province
2020
Chronic kidney disease (CKD) is a public health problem largely caused by diabetes. The epidemiology of diabetes mellitus-related CKD (CKD-DM) could provide specific support to lessen global, regional, and national burden.Data were derived from the GBD 2019 study, including four measures age-standardized rates (ASRs). Estimated annual percentage changes 95% CIs calculated evaluate variation trend ASRs.Diabetes majority new cases patients with in all regions. All ASRs for type 2...
Cuticular waxes cover the aerial surfaces of land plants and protect them from various environmental stresses. Alkanes are major wax components contribute to plant drought tolerance, but biosynthesis regulation alkanes remain largely unknown in wheat (Triticum aestivum L.). Here, we identified functionally characterized a key alkane gene ECERIFERUM1-6A (TaCER1-6A) wheat. The clustered regularly interspaced short palindromic repeat (CRISPR)/CRISPR-associated protein 9 (Cas9)-mediated knockout...
Human papillomavirus (HPV) is a clear etiology of cervical cancer (CC). However, the associations between HPV infection and DNA methylation have not been thoroughly investigated. Additionally, it remains unknown whether HPV‐related signatures can identify subtypes CC stratify prognosis patients. profiles were obtained from The Cancer Genome Atlas to sites. Unsupervised clustering analysis sites was performed determine different subtypes. patients categorized into cluster 1 (Methylation‐H), 2...
Background: Exposure to ambient particulate matter pollution (APMP) is a global health issue that directly affects the human respiratory system. Thus, we estimated spatiotemporal trends in burden of APMP-related diseases from 1990 2019. Methods: Based on Global Burden Disease Study 2019, data were analyzed by age, sex, cause, and location. Joinpoint regression analysis was used analyze temporal different over 30 years. Results: Globally, APMP contributed most chronic obstructive pulmonary...
To identify a glycolysis-related gene signature for the evaluation of prognosis in patients with breast cancer, we analyzed data training set from TCGA database and four validation cohorts GEO ICGC databases which included 1,632 cancer. We conducted GSEA, univariate Cox regression, LASSO, multiple regression analysis. Finally, an 11 - related to glycolysis predicting survival cancer was developed. And Kaplan–Meier analysis ROC analyses suggested that showed good prognostic ability BC TCGA,...
Background Epidemiological trends of type 2 diabetes mellitus attributable to fine particulate matter (PM 2.5 ) pollution remain unclear. Here, we estimated spatiotemporal burden PM pollution, including ambient (APMP) and household air (HAP), from 1990–2019. Methods Data were obtained the Global Burden Disease Study 2019 analyzed by age, sex, year, location. Joinpoint regression analysis was applied in temporal over 30 years. Results Globally, contributed 292.5 thousand deaths 13 million...
The UGT1A1*28 polymorphism was suggested to be significantly connected with irinotecan-induced toxicity and response chemotherapy.However, the results of previous studies are controversial.Hence we carried out a meta-analysis investigate effect on severe diarrhea, neutropenia, patients who had undergone irinotecan-based chemotherapy.The PubMed, Web Science, Wanfang, CNKI databases were searched for clinical trials assessing association combined odds ratios (ORs) 95% confidence intervals...
Abstract Background LncRNA MEG3 expressed abnormally in various cancers including breast cancer, but no studies reported the correlation between SNPs and cancer susceptibility among Chinese women. Methods This study is aimed to explore association three of (rs3087918, rs7158663, rs11160608) cancer. The a population-based case-control 434 patients 700 healthy controls. Genotyping was performed using Sequenom MassArray technique. Function prediction rs3087918 were based on RNAfold lncRNASNP2...
Trophoblast cell surface antigen 2 (TROP2) has been linked to disease prognosis in various human cancers and plays a critical role tumor development, progression, metastasis. A number of relevant studies have published on this topic. meta-analysis the latest literature evaluate value TROP2 as predictive prognosticator cancer was performed.Several online databases were searched, articles retrieved. Overall subcategory meta-analyses performed, results collated.Twenty-seven articles, including...
Motor neuron and pancreas homeobox 1 (MNX1) is a key developmental gene. Previous studies found that it was upregulated in several tumors, but its role breast cancer (BC) remains unclear. In order to have better understanding of this gene BC, we examined the expression MNX1 BC tissues normal by qRT-PCR analyzing data from The Cancer Genome Atlas (TCGA) database. We also assessed association with clinicopathological features investigated impact on survival. Potential molecular function...
Mammalian target of rapamycin (mTOR) gene polymorphisms exert the major effects on regulation transcriptional activity and miRNA binding or splicing, which may be associated with cancer risk by affecting mTOR expression. However, inconsistent results have been previously reported. The present study evaluated correlation between rs2536/rs2295080 breast risk. This case-control was performed 560 patients 583 healthy controls from northwest China. (rs2536 rs2295080) were genotyped Sequenom...
This study explored the associations between common PSCA single-nucleotide polymorphisms (rs2294008, rs2978974, and rs2976392) breast cancer among 560 cases 583 controls (Chinese Han women). We found rs2294008 was significantly associated with a high risk of (homozygote model, odds ratio [OR]: 1.67, 95% confidence interval [CI]: 1.06-2.59; recessive, OR: 1.64, CI: 1.06-2.53). And stratification by menopausal status revealed an association minor allele premenopausal 2.41, 1.03-5.66; 2.80, 95...
This study aimed to assess the associations of two common Flap endonuclease 1 (FEN1) polymorphisms (rs4246215 and rs174538) with breast cancer risk in northwest Chinese women. We conducted a case-control 560 patients 583 age-matched healthy controls from Northwest China. Odds ratios (ORs) 95% confidence intervals (95% CIs) were used estimate associations. found significantly reduced associated T allele rs4246215 (allele model: OR 0.81, CI 0.68-0.96; homozygote = 0.59, 0.40-0.87; recessive...
Abstract Background Previous studies suggested that CXCL12 was involved in the development, metastasis, and invasion of breast cancer, genetic variants were associated with diagnosis prognosis patients cancer. The present study aimed to assess relationships between polymorphisms (rs1801157, rs2297630, rs2839693) susceptibility clinicopathological features Methods A case-control conducted 434 cancer 450 health controls. Student t -test chi-square test used analyze differences age distribution...
Abstract Lung cancer is the leading cause of related deaths worldwide. Nonsmall cell lung cancers (NSCLC), most common histological type cancer, are known to be less well characterized. Long noncoding RNAs a new class regulators. Here, we aimed investigate effect lncRNA PLIC11 in NSCLC progression. In our study, found that was upregulated particularly metastatic tissues. Overexpression enhanced proliferation, migration, and metastasis vitro vivo. Mechanically, could interact with YY1 promote...
Abstract Background Immunohistochemistry (IHC) is an essential technique in surgical and clinical pathology for detecting diagnostic, prognostic, predictive biomarkers personalized cancer therapy. However, the lack of standardization reference controls results poor reproducibility, a reliable tool IHC quantification urgently required. The objective this study was to describe novel approach which H3F3B (histone H3, family 3B) can be used as internal standard quantify protein expression levels...
Serrated lesions are common precancerous pathways in colorectal cancer (CRC), but the process by which they progress to malignancy remains unclear. We aimed elucidate this progression through a single-cell RNA landscape. conducted sequencing on three normal colonic tissues and fifteen SLs (including HPs, SSLs, SSLD, TSAs) integrated these data with datasets containing tumor samples. identified invasive malignant epithelial cell subtypes related CRC progression: SLC1, SLC2, cell. specific is...
Background Increasing evidences have proposed that kisspeptins may be involved in polycystic ovary syndrome (PCOS) including hyperandrogenism. This work aimed to investigate the effect of kisspeptin hyperandrogenism induced by testosterone.Methods The most suitable concentration testosterone induce was determined detecting mRNA changes and macrophages pro-inflammatory cytokines. role investigated RT-PCR cytokines, CCK-8 cell viability, Annexin V-FITC/PI staining followed flow cytometry...
Abstract This study aimed to explore the roles of ERCC1 / XPF gene polymorphisms in occurrence breast cancer Uygur and Han ethnic groups Xinjiang, China. Single nucleotide (SNPs) were detected by TaqMan real‐time PCR. The rs11615 G>A rs2276466 C>G variant frequencies higher patients with than patients, while frequency rs2298881 C>A was patients. We found that (CA vs. CC: OR = 0.35, 95% CI 0.20‐0.60; AA 0.13, 0.04‐0.34; CA + 0.33, 0.18‐0.51; 0.24, 0.08‐0.62; 0.49, 0.29‐0.82)...
Phosphoglycerate mutase (PGAM) is a critical enzyme in glycolysis. PGAM2 abundant several types of tissues and malignant tumours. However, there limited information regarding their clinicopathological significance dysplastic nodules hepatocellular carcinoma (HCC). This study aims to investigate the prognostic value as new biomarker for HCC. The expression level was evaluated by immunohistochemistry liver cirrhosis (n = 10), low-grade 15), high-grade 15) HCCs 20) 178 pairs HCC adjacent...