A5075267220- Liver Disease Diagnosis and Treatment
- Cancer-related molecular mechanisms research
- Pancreatic and Hepatic Oncology Research
- Pancreatitis Pathology and Treatment
- Circular RNAs in diseases
- Metabolism, Diabetes, and Cancer
- Urban Transport and Accessibility
- Vibrio bacteria research studies
- Sulfur Compounds in Biology
- Gastrointestinal disorders and treatments
- Congenital heart defects research
- Molecular Sensors and Ion Detection
- Autophagy in Disease and Therapy
- Genomics and Chromatin Dynamics
- Electrospun Nanofibers in Biomedical Applications
- Circadian rhythm and melatonin
- Nanoparticles: synthesis and applications
- Immune Response and Inflammation
- Urban and Freight Transport Logistics
- HER2/EGFR in Cancer Research
- Bacteriophages and microbial interactions
- Tea Polyphenols and Effects
- Transportation Planning and Optimization
- Ginkgo biloba and Cashew Applications
- Tissue Engineering and Regenerative Medicine
Second Military Medical University
2012-2024
Hainan Medical University
2019-2024
Guangdong Ocean University
2023-2024
Qingdao University
2019-2023
Affiliated Hospital of Qingdao University
2019-2023
Shanghai Ocean University
2020-2022
Shanghai University
2022
Henan Provincial People's Hospital
2018-2022
Zhengzhou University
2021-2022
Ocean University of China
2021
Objectives: Rare pathogenic variants in the SPINK1, PRSS1, CTRC, and CFTR genes have been strongly associated with a risk of developing chronic pancreatitis (CP). However, their potential impact on age disease onset clinical outcomes, as well interactions environmental factors, remain unclear. These issues are addressed here large Chinese CP cohort. Methods: We performed targeted next-generation sequencing four CP-associated 1061 Han patients 1196 controls. To evaluate gene-environment...
We have established a near-infrared two-photon fluorescent probe for the detection of CE2 with high selectivity and sensitivity.
Following the wisdom of nature to assemble functional candidates into exquisite nanoarchitectures is emerging as a promising field research and has been widely applied in biomedical sciences. Owing their excellent properties structural controllability, diversity, dynamic adjustability, prominent biocompatibility, self-assembled come play pivotal role fighting against cancer. This review outlines most up-to-date developments constructing phototherapeutic nanomaterials for photodynamic...
The incidence and burden of stroke in China is increasing rapidly. However, little known about trends mortality during hospitalization. objectives this study were to assess in-hospital among patients with explore influence factors death after China. 109 grade III class A hospitals sampled by multistage stratified cluster sampling. All admitted between 2007 2010 a discharge diagnosis included. Trends assessed. Influence explored using multivariable logistic regression. Overall...
Breast cancer stem cells (BCSCs) are implicated in the initiation and progression of breast responsible for metastasis recurrence. In this study, we attempted to simultaneously target differentiated (DBCCs) BCSCs by using a combination docetaxel (DTX)- sulforaphane (SFN)-loaded poly(D, L-lactide-coglycolide)/hyaluronic acid (PLGA-b-HA)-based nanoparticles. were identified as having an ESA+CD44+CD24– phenotype, which exhibited resistance. Drug-loaded nanoparticles enhanced cytotoxicity...
Purpose: To explore the influence of indoleamine 2,3-dioxygenase (IDO) on macrophage recruitment, polarization and phagocytosis in Aspergillus fumigatus keratitis. Methods: A murine model A. keratitis peritoneal macrophages incubated with hyphae were used. Macrophage recruitment corneas was evaluated using immunofluorescence staining. The macrophages, which stimulated by pretreatment or without 1-methyltryptophan (1-MT), interferon gamma (IFNG), extracellular regulated protein kinases (ERK)...
Abstract The overuse of antibiotics results in the development antibiotic resistance and limits useful life these drugs fighting bacteria, including Aeromonas hydrophila , a well-known opportunistic pathogen that causes serious infections fish other animals. In this study, we investigated adaptive mechanism A. by multiple proteomic methods. Dimethyl labeling label-free methods were performed to compare differential expression proteins response various doses oxytetracycline (OXY). point...
Efficient gene release after intracellular uptake is very important for non-viral delivery systems. To construct a glutathione-responsive system, we developed gold-cysteamine (AuCM)/plasmid DNA (pDNA)/poly TAT (pTAT)/hyaluronic acid (HA) nanocomplexes (AuCM/pDNA/pTAT/HA) in this study. The AuCM/pDNA/pTAT/HA possessed small size less than 200 nm and negative zeta potential of -17 ± 4 mV. multilayer structure was verified by UV-Vis spectra, surface charges, dynamic light scattering. Morphology...