A5100680718- Scoliosis diagnosis and treatment
- Spinal Fractures and Fixation Techniques
- Spine and Intervertebral Disc Pathology
- Pelvic and Acetabular Injuries
- Metal-Organic Frameworks: Synthesis and Applications
- Sepsis Diagnosis and Treatment
- Meat and Animal Product Quality
- Cerebrovascular and Carotid Artery Diseases
- Radiomics and Machine Learning in Medical Imaging
- RNA modifications and cancer
- Biochemical effects in animals
- Ferroptosis and cancer prognosis
- Toxic Organic Pollutants Impact
- Lung Cancer Treatments and Mutations
- Crystallization and Solubility Studies
- COVID-19 Clinical Research Studies
- Effects and risks of endocrine disrupting chemicals
- Effects of Environmental Stressors on Livestock
- Cancer-related molecular mechanisms research
- Adipose Tissue and Metabolism
- Inflammatory mediators and NSAID effects
- Estrogen and related hormone effects
- X-ray Diffraction in Crystallography
- SARS-CoV-2 and COVID-19 Research
- Extracellular vesicles in disease
Jinan University
2024-2025
Peking University
2016-2025
Peking University Third Hospital
2020-2025
Sinopec (China)
2025
Jiangxi Provincial Cancer Hospital
2018-2024
Kunming Medical University
2024
Chinese Academy of Sciences
2016-2024
University of Chinese Academy of Sciences
2014-2024
Hunan University
2024
Beijing Chao-Yang Hospital
2022-2024
Abstract Bisphenol A (BPA) is used in the production of plastic but has oestrogenic activity. Therefore, BPA substitutes, such as fluorene-9-bisphenol (BHPF), have been introduced for so-called ‘BPA-free’ plastics. Here we show that BHPF released from commercial bottles into drinking water and anti-oestrogenic effects mice. We demonstrate activity vitro and, an uterotrophic assay mice, induces low uterine weight, atrophic endometria causes adverse pregnancy outcomes, even at doses lower than...
Abstract Background With the effective prevention and control of COVID‐19 in China, number cured cases has increased significantly. Further monitoring disease prognosis “relapse” epidemic become next focus work. This study analysed clinical discharged patients by their SAR‐CoV‐2 nucleic acid status, which provided a theoretical basis for medical institutions to formulate discharge standards follow‐up management patients. Methods We included 13 who were quarantined 4 weeks at home. The...
<h3>Importance</h3> The proportion of daily wearers eyeglasses among patients with coronavirus disease 2019 (COVID-19) is small, and the association between wear COVID-19 susceptibility has not been reported. <h3>Objective</h3> To study wearing to COVID-19. <h3>Design, Setting, Participants</h3> This cohort enrolled all inpatients in Suizhou Zengdu Hospital, Suizhou, China, a designated hospital for treatment area, from January 27 March 13, 2020. was diagnosed according fifth edition Chinese...
Abstract Background The performance of the sepsis-induced coagulopathy (SIC) and sequential organ failure assessment (SOFA) scores in predicting prognoses patients with sepsis has been validated. This study aimed to investigate time course SIC SOFA their association outcomes sepsis. Methods prospective enrolled 209 admitted emergency department. were assessed on days 1, 2, 4. Patients categorized into survivor or non-survivor groups based 28-day survival. We conducted a generalized...
The tumor microenvironment (TME) is a dynamic system orchestrated by intricate cell-to-cell crosstalk. Specifically, macrophages within the TME play crucial role in driving progression. Exosomes are key mediators of communication between cells and TME. However, mechanisms underlying exosome-driven crosstalk during colorectal cancer (CRC) progression remain incompletely elucidated.
BACKGROUND Multimodal analgesia can improve postoperative pain and possibly accelerate functional recovery after surgery. Serratus plane block (SPB) is a novel, ultrasound-guided regional anaesthetic technique for complete of the anterolateral chest wall. But, effect SPB on quality breast cancer surgery has not been established. OBJECTIVE To test hypothesis that pre-operative would enhance following DESIGN A randomised, double-blind, parallel-group, placebo-controlled trial. SETTING Single...
In this paper, we describe the discovery and optimization of a series noncovalent reversible epidermal growth factor receptor inhibitors EGFRL858R/T790M/C797S. One most promising compounds, 25g, inhibited enzymatic activity EGFRL858R/T790M/C797S with an IC50 value 2.2 nM. Cell proliferation assays showed that 25g effectively selectively EGFRL858R/T790M/C797S-dependent cells. This which occupy both ATP binding site allosteric EGFR kinase, may serve as basis for development fourth-generation...
We aimed to report the epidemiological and clinical characteristics of hospitalized patients with coronavirus disease-19 (COVID-19) in Zengdu District, Hubei Province, China.Clinical data on COVID-19 inpatients Hospital from January 27 March 11, 2020 were collected; this is a community hospital an area surrounding Wuhan supported by volunteer doctors. All included study. The findings, features, laboratory radiologic manifestations, outcomes these analyzed. followed up for until 22, 2020....
Abstract The capability to gather heterogeneous data, alongside the increasing power of artificial intelligence examine it, leading a revolution in harnessing multimodal data life sciences. However, most approaches are limited unimodal leaving integrated across modalities relatively underdeveloped computational pathology. Pathogenomics, as an invasive method integrate advanced molecular diagnostics from genomic morphological information histopathological imaging, and codified clinical enable...
Abstract The estrogenicity of parabens at human exposure levels has become a focus concern due to the debate over whether is strong enough play role in increased incidence breast cancer. In this study, uterotrophic activities methylparaben (MP) and ethylparaben (EP) doses close acceptable daily intake as allocated by JECFA were demonstrated immature Sprague-Dawley rats intragastric administration, up-regulations estrogen-responsive biomarker genes found uteri quantitative real-time RT–PCR...
Leeches secrete various biologically active substances which have important medical and pharmaceutical values in antithrombotic treatments. Here, we provide a high quality genome of two Asian medicinal leeches Hirudo nipponia tianjinensis, based on which, identified 22 gene families, including fourteen coagulation inhibitors, four platelet aggregation three fibrinolysis enhancers, one tissue penetration enhancer. The total numbers genes were similar between H. (N = 86) tianjinensis 83)....
Abstract Background Radiotherapy can modulate systemic antitumor immunity, while immune status in the tumor microenvironment also influences efficacy of radiotherapy, but relevant molecular mechanisms are poorly understood lung adenocarcinoma (LUAD). Methods In this study, we innovatively proposed a radiotherapy response classification for LUAD, and discovered ESYT3 served as suppressor radioimmune sensitizer. expression was measured both radioresistant radiosensitive LUAD tissues cells. The...
Ankylosing spondylitis (AS) is a systemic chronic inflammatory disease. Andersson lesion (AL) late complication of advanced AS. Idiopathic spinal cord hernia (ISCH) rare disorder the cord. However, according to our literature review, simultaneous occurrence AL together with ISCH in single AS patient had never been reported. A 49-year-old male reported 30-year history thoracolumbar pain and limited mobility was diagnosed dual complications ICSH. Before correction surgery, physical...
Optimization of small molecule donor morphology in OSCs: allyl group-driven enhancements H35 for superior PCEs 15.21% (ASM) and 10.78% (SMD:PA) via improved miscibility, domain structure, charge transfer.
A prospective case-control study. This study aimed to analyze the paravertebral muscle changes in patients with adolescent idiopathic scoliosis (AIS) and determine myopathological associated clinical progression of AIS. The incidence AIS is significant globally worsens before bone maturation, causing a serious effect. Many studies have investigated its causes-such as genetic, epigenetic, hormonal factors-but more research remains warranted. enrolled 40 AIS, 20 congenital (CS), spinal...
Finding an optimal treatment strategy for adolescent idiopathic scoliosis (AIS) patients remains challenging because of its intrinsic complexity. For mild to moderate with lower skeletal growth potential (Risser 3-5), most clinicians agree observation treatment; however, the curve progression that occurs during puberty, period, and even in adulthood, a issue clinicians. The aim study is investigate efficacy Schroth exercise AIS 3-5) (Cobb angle 20°-40°).From 2015 2017, data 64 diagnosed...