A5015497258- CAR-T cell therapy research
- Immunotherapy and Immune Responses
- Cancer Immunotherapy and Biomarkers
- Immune Cell Function and Interaction
- Viral Infectious Diseases and Gene Expression in Insects
- T-cell and B-cell Immunology
- Aquaculture disease management and microbiota
- Cell Adhesion Molecules Research
- Biosimilars and Bioanalytical Methods
- Plant-Microbe Interactions and Immunity
- Constructed Wetlands for Wastewater Treatment
- CRISPR and Genetic Engineering
- Immune Response and Inflammation
- Orthoptera Research and Taxonomy
- Hippo pathway signaling and YAP/TAZ
- Polysaccharides and Plant Cell Walls
- Wastewater Treatment and Nitrogen Removal
- Ubiquitin and proteasome pathways
- Hepatocellular Carcinoma Treatment and Prognosis
- Cancer, Hypoxia, and Metabolism
- Enzyme Production and Characterization
- Wnt/β-catenin signaling in development and cancer
- Legume Nitrogen Fixing Symbiosis
- Cancer Mechanisms and Therapy
- Studies on Chitinases and Chitosanases
Minzu University of China
2025
St. Jude Children's Research Hospital
2021-2024
Beijing Chao-Yang Hospital
2024
Capital Medical University
2023-2024
Liaocheng University
2023
South China Agricultural University
2017-2023
China Rehabilitation Research Center
2023
Northwestern University
2017-2020
Zhengzhou University
2020
Loyola University Chicago
2014-2019
Abstract Background The performance of the sepsis-induced coagulopathy (SIC) and sequential organ failure assessment (SOFA) scores in predicting prognoses patients with sepsis has been validated. This study aimed to investigate time course SIC SOFA their association outcomes sepsis. Methods prospective enrolled 209 admitted emergency department. were assessed on days 1, 2, 4. Patients categorized into survivor or non-survivor groups based 28-day survival. We conducted a generalized...
Hepatocellular carcinoma (HCC) is the third most common cause of cancer death worldwide and patients with HCC have limited treatment options. Focal adhesion kinase (FAK) overexpressed in many specimens, offering a potential target for treatment. However, role FAK hepatocarcinogenesis remains elusive. Establishing whether expression plays development necessary to determine it viable therapeutic target. In this study, we generated mice hepatocyte‐specific deletion Fak investigated an oncogenic...
There is an urgent need to understand the molecular signaling pathways that drive or mediate development of hepatocellular carcinoma (HCC). The focal adhesion kinase (FAK) gene protein tyrosine 2 amplified in 16.4% Cancer Genome Atlas HCC specimens, and its amplification leads increased FAK mRNA expression. It not known whether overexpression alone sufficient induce it must cooperate some ways with other oncogenes. In this study, we found 34.8% human samples also show β‐catenin mutations,...
Financial Risk Management (FRM) is crucial for organizations navigating complex and volatile economic conditions, as it aids in identifying mitigating potential losses. Conventional FRM approaches are inadequate because they do not incorporate vagueness variability financial data. To overcome these challenges, this research presents interval-valued picture fuzzy measurement alternatives rankings according to the Compromise Solution (IVPF-MARCOS) method. The IVPF-MARCOS method ranks...
Liver fibrosis can progress to cirrhosis and result in serious complications of liver disease. The pathogenesis involves the activation hepatic stellate cells (HSCs), underlying mechanisms which are not fully known. Emerging evidence suggests that classic histone deacetylases play a role fibrosis, but another subfamily deacetylases, sirtuins, development remains unknown. In this study, we found blocking activity sirtuin 2 (SIRT2) by using inhibitors or shRNAs significantly suppressed...
UDP-xylose (UDP-Xyl) is synthesized by UDP-glucuronic acid decarboxylases, also termed UDP-Xyl synthases (UXSs). The Arabidopsis genome encodes six UXSs, which fall into two groups based upon their subcellular location: the Golgi lumen and cytosol. latter group appears to play an important role in xylan biosynthesis. Cytosolic transported three transporters (UXT1, 2, 3). However, while single mutants affected transporter 1 (UXT1) showed a substantial reduction cell wall xylose content,...
Hepatocellular carcinoma (HCC) is the fifth most common primary cancer and second largest cause of cancer‐related death worldwide. The first‐line oral chemotherapeutic agent sorafenib only increases survival in patients with advanced HCC by less than 3 months. Most have shown limited response rates benefits sorafenib. Although an inhibitor multiple kinases, including serine/threonine‐protein kinase c‐Raf, B‐Raf, vascular endothelial growth factor receptor (VEGFR)‐1, VEGFR‐2, VEGFR‐3,...
There is an urgent need to develop new and more effective therapeutic strategies agents treat hepatocellular carcinoma (HCC). We have recently found that deletion of Fak in hepatocytes before tumors form inhibits tumor development prolongs survival animals a c-MET (MET)/β-catenin (CAT)-driven HCC mouse model. However, it has yet be determined whether FAK expression promotes MET/CAT-induced progression after initiation. In addition, remains unclear through its kinase activity. generated...
Understanding the molecular mechanisms of liver regeneration is essential to improve survival rate patients after surgical resection large amounts tissue. Focal adhesion kinase (FAK) regulates different cellular functions, including cell survival, proliferation and migration. The role FAK in remains unknown. In this study, we found that Fak activated induced during two-thirds partial hepatectomy (PHx). We used mice with liver-specific deletion investigated 2/3 PHx model (removal liver)....
Purpose To test the hypothesis that biomarkers of fluorine 18 (18F) fluorodeoxyglucose (FDG) positron emission tomography (PET) can be used for early detection therapeutic response to irreversible electroporation (IRE) liver tumor in a rodent model. Materials and Methods The institutional animal care use committee approved this study. Rats were inoculated with McA-RH7777 cells left median lateral lobes. Tumors allowed grow 7 days reach size typically at least 5 mm longest diameter, as...
Abstract Purpose To investigate the association between body composition and adverse clinical outcomes in older patients with sepsis emergency department. Methods Body composition, including skeletal muscle area, index (SMI), mean density (SMD), intramuscular fat was measured at level of third lumbar vertebra (L3) on abdominal computed tomography scans. Clinical included 90-day mortality, readmission, discharge to long-term care. According sex-specific cut-off values L3 SMI SMD, were divided...