A5100625978- Lung Cancer Research Studies
- Epigenetics and DNA Methylation
- RNA modifications and cancer
- Cancer-related gene regulation
- MicroRNA in disease regulation
- Peptidase Inhibition and Analysis
- Cancer, Hypoxia, and Metabolism
- Cancer-related molecular mechanisms research
- Cancer-related Molecular Pathways
- Pancreatic and Hepatic Oncology Research
- Protein Degradation and Inhibitors
- Cancer Research and Treatments
- Circular RNAs in diseases
- Genomics and Chromatin Dynamics
- Chromatin Remodeling and Cancer
- Plant nutrient uptake and metabolism
- Plant Stress Responses and Tolerance
- SARS-CoV-2 and COVID-19 Research
- Photosynthetic Processes and Mechanisms
- Hydrogen's biological and therapeutic effects
- Mesenchymal stem cell research
- RNA Research and Splicing
- Liver Disease Diagnosis and Treatment
- Tissue Engineering and Regenerative Medicine
- Pluripotent Stem Cells Research
Northwestern University
2020-2025
Second Affiliated Hospital of Zhengzhou University
2024
Midwestern University
2024
Tianjin Medical University General Hospital
2017-2023
Beihang University
2021-2023
Guiyang Medical University
2022
Affiliated Hospital of Guizhou Medical University
2022
Zhongda Hospital Southeast University
2021
Xuzhou Medical College
2020-2021
Fourth People's Hospital of Sichuan Province
2021
NF-κB-mediated inflammatory phenotypic switching of vascular smooth muscle cells (VSMCs) plays a central role in atherosclerosis and neointimal formation. However, little is known about the roles circRNAs regulation NF-κB signaling. Here, we identify involvement circ-Sirt1 that was one transcripts SIRT1 host gene VSMC response hyperplasia. First, cytoplasm, directly interacts with sequesters p65 from nuclear translocation induced by TNF-α sequence-dependent manner. The inhibitory complex...
Colorectal cancer (CRC) is one of the most lethal and prevalent malignancies. While overexpression pioneer factor GATA6 in CRC has been linked with metastasis, its role genome-wide gene expression dysregulation remains unclear. Through studies primary human tissues analysis TCGA data, we found that preferentially binds at CRC-specific active enhancers, enrichment enhancer-promoter loop anchors. protein also physically interacts CTCF, suggesting critical 3D genome organization. The ablation...
Abstract Background Small cell lung cancer (SCLC) is a more aggressive subtype of that often results in rapid tumor growth, early metastasis, and acquired therapeutic resistance. Consequently, such phenotypical characteristics SCLC set limitations on viable procedural options, making it difficult to develop both screenings effective treatments. In this study, we examine novel mechanistic insight cells could potentially provide sensitive alternative for patients. Methods Biochemistry studies,...
Small cell lung cancer (SCLC), accounting for around 13% of all cancers, often results in rapid tumor growth, early metastasis, and acquired therapeutic resistance. The POU class 2 homeobox 3 (POU2F3) is a master regulator tuft identity defines the SCLC-P subtype that lacks neuroendocrine markers. Here, we have identified previously uncharacterized protein, C11orf53, which coexpressed with POU2F3 both SCLC lines patient samples. Mechanistically, C11orf53 directly interacts recruited to...
The long-term survival of patients with advanced urothelial carcinoma (UCa) is limited because innate resistance to treatment. We identified elevated expression the histone methyltransferase EZH2 as a hallmark aggressive UCa and hypothesized that inhibition, via small-molecule catalytic inhibitor, might have antitumor effects in UCa. Here, carcinogen-induced mouse bladder cancer model, reduction tumor progression an increase immune infiltration upon inhibition were observed. Treatment mice...
Abstract Recent studies have identified a previously uncharacterized protein C11orf53 (now named POU2AF2/OCA-T1), which functions as robust co-activator of POU2F3, the master transcription factor is critical for both normal and neoplastic tuft cell identity viability. Here, we demonstrate that POU2AF2 dictates opposing transcriptional regulation at distal enhance elements. Loss leads to an inhibition active enhancer nearby genes, such derepression Polycomb-dependent poised are viability...
Aims: microRNA-101 (miR-101) is down-regulated in several cancers. In this study, we explored the effects of dysregulated miR-101 on breast cancer cells and underlying mechanisms. Methods: level was quantified by real-time RT-PCR. Cell viability analyzed MTT assay. Apoptosis detected flow cytometry TUNEL Moreover, protein expression determined Western blot. Results: markedly reduced both human samples cultured cell lines (MCF-7, MDA-MB-231). Overexpression inhibited proliferation promoted...
Set1A and Set1B, two members of the COMPASS family methyltransferases that methylate histone H3 lysine 4 (H3K4) residue, have been accredited as primary depositors global H3K4 trimethylation (H3K4me3) in mammalian cells. Our previous studies mouse embryonic stem cells (ESCs) demonstrated deleting enzymatic SET domain does not perturb bulk H3K4me3, indicating possible compensatory roles played by other methyltransferases. Here, we generated a series ESC lines harboring compounding mutations...
Small cell lung cancer (SCLC) is an aggressive disease, with patients diagnosed either early-stage, limited stage, or extensive stage of SCLC tumor progression. Discovering and targeting the functional biomarkers for will be crucial in understanding molecular basis underlying tumorigenesis to better assist improving clinical treatment. Emerging studies have demonstrated that dysregulations BAP1 histone H2A deubiquitinase complex are collectively associated pathogenesis human SCLC. Here, we...
Neural inflammatory response is a crucial pathological change in intracerebral hemorrhage (ICH) which accelerates the formation of perihematomal edema and aggravates neural cell death. Although surgical drug treatments for ICH have advanced rapidly recent years, therapeutic strategies that target control neuroinflammation are still limited. Exosomes important carriers information transfer among cells. They also been regarded as promising tool translational medicine, with low immunogenicity,...
The testis-specific BET protein BRDT structurally resembles the ubiquitous BRD4 and is misexpressed in cancer, we show that misexpression may affect lung cancer progression. knockdown cells slowed tumor growth prolonged survival a xenograft model. Comparative characterization of PTEFb complex participation chromatin binding indicates BRD4-redundant BRD4-distinct functions. Unlike dual depletion, individual or did not impair transcriptional responses to hypoxia BRDT-expressing cells,...
Alzheimer’s disease (AD) is the most common neurodegenerative in world. Although exact causes of AD have not yet been fully elucidated, cholinergic dysfunction, mitochondrial damage, oxidative stress and neuroinflammation recognized as influential factors. Current drugs that are designed to address only a single target unable mitigate or prevent progression this complicated disease, so new disease-modifying urgently needed. Chinese herbs with thousand years effective usage might be good...
Background: Sinapine thiocyanate (ST), an alkaloid isolated from the seeds of cruciferous species, has exhibited anti-inflammatory, anti-malignancy, and anti-angiogenic effects in previous studies. However, molecular mechanisms action ST pancreatic cancer (PC) are still limited. Materials methods: PC cells were treated with different concentrations (0, 20, 40, 80 μM) ST. The proliferative ability vitro was determined using cell count kit-8 (CCK-8), 5-ethynyl-2' deoxyuridine, colony...
Antisense oligodeoxynucleotide (A-ODN) inhibition works well in animal cells. However, there have been few successful examples to date of its application plants, and more specifically whether the technique can be used pollen tubes as a model plant cell growth. NtGNL1 plays an important role tube development was thus selected indicator assess biological effects A-ODN. An A-ODN down-regulate expression tobacco showed that A-ODNs could quickly enter through thick wall membrane effectively block...
// Ping Niu 1,* , Aibek Smagul 2,* Lu Wang 3 Aiman Sadvakas 2 Ying Sha Laura M. Pérez 4 Aliya Nussupbekova Aday Amirbekov Akan A. Akanov Beatriz G. Gálvez I. King Jordan 3,5 and Victoria V. Lunyak 6 1 Department of Pediatrics, Renmin Hospital Wuhan University, Wuhan, China S.D. Asfendiyarov Kazakh National Medical Almaty, Kazakhstan School Biology, Georgia Institute Technology, Atlanta, GA Cardiac Development Repair Department, Center for Cardiovascular Research (CNIC), Madrid, Spain 5...
Ankylosing spondylitis (AS) is a systemic, chronic, and inflammatory rheumatic disease that affects 0.2% of the population. Current diagnostic criteria for activity rely on subjective Bath Spondylitis Disease Activity Index scores. Here, we aimed to discover panel serum protein biomarkers. First, tandem mass tag (TMT)-based quantitative proteomics was applied identify differential proteins between 15 pooled active AS 60 healthy subjects. Second, cohort 1 328 humans, including 138 190...
Vaccination is a cost-effective medical intervention. Inactivated whole virusor large protein fragments-based severe acute respiratory syndrome coronavirus (SARS-CoV-2) vaccines have high unnecessary antigenic load to induce allergenicity and/orreactogenicity, which can be avoided by peptide of short fragments that may highly targeted immune response. However, epitope identification and delivery remain the major obstacles in developing vaccines. Here, multi-source data integrated linear...
An imbalance in the activities of Polycomb and Trithorax complexes underlies numerous human pathologies, including cancer. The BRCA1 associated protein-1 (BAP1) deubiquitinase negatively regulates activity recruits histone H3K4 methyltransferase, mixed-lineage leukemia protein 3 (MLL3) within Complex Proteins Associated with Set1 (COMPASS), to enhancers tumor suppressor genes. We previously demonstrated that BAP1-MLL3 pathway is mutated several cancers, yet how BAP1 MLL3 its target loci...
Emotional conflict refers to the influence of task irrelevant affective stimuli on current set. Previously used emotional face-word tasks have produced certain electrophysiological phenomena, such as an enhanced N450 and slow potential; however, it remains unknown whether these effects emerge in other tasks. The present study body-word investigate neural dynamics reflected by response time, accuracy, event-related potentials, which were recorded with aim replicating previously observed...
Mechanical ventilation can cause ventilator-induced lung injury (VILI) and fibrosis; however, the underlying mechanisms are still not fully understood. RNA sequencing is a powerful means for detecting vitally important protein-coding transcripts long non-coding RNAs (lncRNAs) on genome-wide scale, which may be helpful reducing this knowledge gap. Ninety C57BL/6 mice were subjected to either high tidal volume or sham operation, then with randomly allocated periods of recovery 0, 1, 3, 5, 7,...