A5047976862- Epigenetics and DNA Methylation
- Bladder and Urothelial Cancer Treatments
- Ferroptosis and cancer prognosis
- Genomics and Chromatin Dynamics
- Acute Myeloid Leukemia Research
- RNA modifications and cancer
- Cancer Mechanisms and Therapy
- Lung Cancer Research Studies
- Vitamin D Research Studies
- Protein Degradation and Inhibitors
- Cancer Genomics and Diagnostics
- Cancer Research and Treatments
- Atherosclerosis and Cardiovascular Diseases
- RNA Research and Splicing
- Adipokines, Inflammation, and Metabolic Diseases
- CRISPR and Genetic Engineering
- Chromatin Remodeling and Cancer
- Metastasis and carcinoma case studies
Northwestern University
2020-2025
Midwestern University
2022-2024
Abstract Recent studies have identified a previously uncharacterized protein C11orf53 (now named POU2AF2/OCA-T1), which functions as robust co-activator of POU2F3, the master transcription factor is critical for both normal and neoplastic tuft cell identity viability. Here, we demonstrate that POU2AF2 dictates opposing transcriptional regulation at distal enhance elements. Loss leads to an inhibition active enhancer nearby genes, such derepression Polycomb-dependent poised are viability...
Colorectal cancer (CRC) is one of the most lethal and prevalent malignancies. While overexpression pioneer factor GATA6 in CRC has been linked with metastasis, its role genome-wide gene expression dysregulation remains unclear. Through studies primary human tissues analysis TCGA data, we found that preferentially binds at CRC-specific active enhancers, enrichment enhancer-promoter loop anchors. protein also physically interacts CTCF, suggesting critical 3D genome organization. The ablation...
Muscle-invasive bladder cancers are characterized by their distinct expression of luminal and basal genes, which could be used to predict key clinical features such as disease progression overall survival. Transcriptionally, FOXA1, GATA3, PPARG shown essential for subtype-specific gene regulation subtype switching, while TP63, STAT3, TFAP2 family members critical genes. Despite these advances, the underlying epigenetic mechanisms 3D chromatin architecture responsible in cancer remain...
Chronic unresolved vascular inflammation is a critical factor in the development of atherosclerosis. Cardiovascular immunotherapy has therefore become recent focus for treatment, with objective to develop approaches that can suppress excessive inflammatory responses by modulating specific immune cell populations. A benefit such immunomodulatory strategies low dosage stimulation key populations, like antigen presenting cells, subsequently propagate strong proliferation and therapeutic from...
Abstract Colorectal cancer (CRC) is one of the most lethal and prevalent malignancies with elusive molecular causes. While abnormal activity transcription factors has been reported as a vital component progression, mechanism through which they function remains unclear. Here, analysis primary human CRC tissue data, we identified GATA6 specific regulator, whose expression upregulation potentially associated promoter hypomethylation. In genome, showed preferential binding at tumor active...
Abstract Acute myeloid leukemia (AML) represents a set of heterogeneous malignancies hallmarked by mutations in epigenetic modifiers, transcription factors, and kinases that can cause reshaping. It is unclear to what extent AML drive chromatin 3D structure alteration contribute transformation. We first performed Hi-C whole-genome sequencing 25 patient samples seven healthy donor samples, identified recurrent alterations A/B compartments, TADs, loops are unique different subtypes. To...