A5101648805- Electrocatalysts for Energy Conversion
- Electrochemical Analysis and Applications
- Advances in Cucurbitaceae Research
- PI3K/AKT/mTOR signaling in cancer
- RNA modifications and cancer
- Advanced battery technologies research
- Advanced Radiotherapy Techniques
- Ubiquitin and proteasome pathways
- Radiation Therapy and Dosimetry
- Adaptive Control of Nonlinear Systems
- Catalytic Processes in Materials Science
- Medical Imaging Techniques and Applications
- Energy Efficient Wireless Sensor Networks
- Fuel Cells and Related Materials
- Cancer, Lipids, and Metabolism
- Synthesis and Biological Activity
- Hippo pathway signaling and YAP/TAZ
- Stability and Control of Uncertain Systems
- Autophagy in Disease and Therapy
- Chemical Synthesis and Analysis
- Robotics and Sensor-Based Localization
- Protein Tyrosine Phosphatases
- Circular RNAs in diseases
- Inflammasome and immune disorders
- Berberine and alkaloids research
Northwestern University
2024-2025
Hubei University of Medicine
2017-2025
Tianjin University
2020-2024
Taihe Hospital
2024
Air Force Medical University
2022-2024
Chongqing Medical University
2024
Sun Yat-sen University
2021-2024
The Affiliated Yongchuan Hospital of Chongqing Medical University
2024
Xijing Hospital
2022-2024
Qingdao University
2020-2023
The aberrant expression of cancerous inhibitor protein phosphatase 2A (CIP2A) indicates poor prognosis and promotes EMT metastasis. EMT, a crucial cellular process that occurs during cancer progression metastasis, has been reported to promote drug resistance in several previous studies. Consequently, ongoing research focused on exploring therapeutic options for preventing delay or reverse resistance. Polyphyllin I (PPI) is natural component extracted from Paris polyphylla displays...
Abstract Recent studies have identified a previously uncharacterized protein C11orf53 (now named POU2AF2/OCA-T1), which functions as robust co-activator of POU2F3, the master transcription factor is critical for both normal and neoplastic tuft cell identity viability. Here, we demonstrate that POU2AF2 dictates opposing transcriptional regulation at distal enhance elements. Loss leads to an inhibition active enhancer nearby genes, such derepression Polycomb-dependent poised are viability...
Non-small cell lung cancer (NSCLC) patients carrying an epidermal growth factor receptor (EGFR) mutation are initially sensitive to EGFR-tyrosine kinase inhibitors (TKIs) treatment, but soon develop acquired resistance. The treatment effect of EGFR-TKIs-resistant NSCLC still faces challenges. Cucurbitacin B (CuB), a triterpene hydrocarbon compound isolated from plants various families and genera, elicits anticancer effects in variety types. However, whether CuB is viable option for...
PtCu/PdCu core–shell tripods with adjustable shell thickness and components were synthesized via seed-mediated galvanic replacement strategy. This study provides an effective strategy for the design of multicomponent catalysts.
Mutations or homozygous deletions of MHC class II (MHC-II) genes are commonly found in B cell lymphomas that develop immune-privileged sites and have been associated with patient survival. However, the mechanisms regulating MHC-II expression, particularly through genetic epigenetic factors, not yet fully understood. In this study, we identified a key signaling pathway involving histone H2AK119 deubiquitinase BRCA1 protein 1 (BAP1), interferon regulatory factor (IRF1), transactivator (CIITA),...
Polyphyllin I (PPI) is a natural compound extracted from the rhizomes of Paris polyphylla and has been used to treat fevers headaches in China. In present study, antitumor activity PPI prostate cancer (PC) cells was evaluated. At low doses, decreased proliferation, invasion epithelial-mesenchymal transition (EMT) PC cells. expression matrix metalloproteinase 7 (MMP7), an enzyme that critical for tumor metastasis. also Snail vimentin, which are EMT-associated factors. Additionally, suppressed...
Ethoxysanguinarine (Eth) is a benzophenanthridine alkaloid extracted from Macleaya cordata (Willd) R. Br. It possesses antibacterial and antiviral activities offers therapeutic benefits for the treatment of respiratory syndrome virus-induced cytopathic effects. However, effect Eth on human tumors its pharmacological effects remain to be elucidated, together with cellular target. Here, we examined breast cancer (BC) cells. We found that at low doses, strongly inhibited viability BC cell lines...
Without introducing any surfactants and capping agents, concave Pt nanocubes, willow-like nanocrystals, spherical nanoparticles were synthesized at different deposition potentials using a square-wave potential electrodeposition procedure. As the decreased from double layer region to hydrogen underpotential finally into evolution reaction under acidic conditions, morphology of nanocrystals changed nanocubes. We took advantage unique features adsorption/desorption on surface in regions achieve...
BACKGROUND Colorectal carcinoma (CRC) is one of the most frequently diagnosed malignancies. Cucurbitacin B (CuB) a natural compound isolated from herbs and shows anticancer activity in several cancers. MATERIAL AND METHODS Here, we analyzed effects different CuB concentrations on proliferative invasive behaviors CRC cells using MTT, clonogenic assay, Transwell invasion, wound healing assays. Flow cytometry was performed to measure apoptotic cells. Western blot real-time PCR were used...
Acute myeloid leukemia (AML) is the most common subtype of hematological malignancy in humans, and its incidence increases with age. The treatment AML still faces challenges. Therefore, there an urgent need to develop more effective targeted therapies. receptor tyrosine kinase C-KIT confers critical proliferative signals AML. Cancerous inhibitor protein phosphatase 2A (CIP2A) endogenous (PP2A), which promotes growth transformation various solid tumors. These actions make CIP2A a promising...
To address the surface reconstruction issue, this paper proposes an efficient and accurate approach for registration of multiview range scans. It has a good objective function designed, where all parameters are involved. solve function, coarse-to-fine is proposed, each scan should be sequentially registered to coarse model, which reconstructed by other scans with initial alignment. By applying trimmed iterative closest point algorithm, it can obtain results scan, then immediately utilized...
Alveolar bone loss has long been a challenge in clinical dental implant therapy. Simvastatin (SV) demonstrated to exert excellent anabolic effects on bone. However, the successful use of SV increase formation vivo largely depends local concentration at site action, and there have continuing efforts develop an appropriate delivery system. Specifically, nanostructured lipid carrier (NLC) systems become popular type encapsulation Therefore, SV-loaded NLCs (SNs) (179.4 nm diameter) were...
The development of catalysts with high efficiency and stability in acidic electrolytes for oxygen evolution reaction (OER) is critical to water electrolyzers renewable energy conversion has been eagerly explored the shape-controlled synthesis noble metals such as Ir Ru. However, expensive prices Ru severely hamper their wide use OER. In this work, we show an efficient method one-pot Ir0.4Cu0.6 microspheres. Electrochemical tests showed that Ir–Cu microspheres as-synthesized delivered a...
Cancerous inhibitor of protein phosphatase 2A (CIP2A) is a human oncoprotein that overexpressed in multiple types tumors and promotes the proliferation transformation cancer cells. However, whether CIP2A can be new drug target for glioblastoma multiforme (GBM) largely unclear. In present study, we demonstrated overexpression invasive behavior GBM, natural compound, cucurbitacin B (CuB), shows an anti‐proliferative anti‐invasion effect GBM cell lines. CuB effectively induces apoptosis,...
Signal transducer and activator of transcription 3 (STAT3) plays a key role in promoting tumor malignant progression. Suppression hyperactivated STAT3 signaling has emerged as potential therapeutic strategy for many cancer types. In this study, the effect 6-ethoxydihydrosanguinarine (6-EDS), secondary transformation product formed from dihydrosanguinarine, isolated Macleaya (Papaveraceae), was evaluated gastric (GC). We demonstrated that 6-EDS inhibited survival, migration, invasiveness GC...