A5014356411- MRI in cancer diagnosis
- Advanced MRI Techniques and Applications
- Radiomics and Machine Learning in Medical Imaging
- Prostate Cancer Treatment and Research
- Prostate Cancer Diagnosis and Treatment
- Medical Imaging Techniques and Applications
- Renal cell carcinoma treatment
- Bladder and Urothelial Cancer Treatments
- Epigenetics and DNA Methylation
- Lanthanide and Transition Metal Complexes
- AI in cancer detection
- Advanced Neuroimaging Techniques and Applications
- Renal and related cancers
- Sarcoma Diagnosis and Treatment
- Cancer Genomics and Diagnostics
- Molecular Biology Techniques and Applications
- Cancer-related gene regulation
- Cancer-related molecular mechanisms research
- Urinary Bladder and Prostate Research
- Urologic and reproductive health conditions
- Cancer, Lipids, and Metabolism
- Cancer Cells and Metastasis
- Microtubule and mitosis dynamics
- Cancer Immunotherapy and Biomarkers
- Sirtuins and Resveratrol in Medicine
Advanced Imaging Research (United States)
2016-2025
Oregon Health & Science University
2016-2025
University of Wisconsin–Madison
2015-2024
University of Wisconsin Carbone Cancer Center
2013-2024
First Affiliated Hospital Zhejiang University
2017-2024
Guangdong University of Technology
2023-2024
First Affiliated Hospital of Xiamen University
2023
First Affiliated Hospital of Fujian Medical University
2023
Fujian Medical University
2023
The Affiliated Yongchuan Hospital of Chongqing Medical University
2021
Purpose: To prospectively evaluate the diagnostic performance of magnetic resonance (MR) spectroscopy in patients with suspicious lesions or biopsy-proved cancers at MR imaging by using histologic findings as reference standard. Materials and Methods: After institutional review board approval informed consent were obtained for this HIPAA-compliant study, breast was performed malignant measuring 1 cm larger imaging. Single-voxel data collected from a single rectangular volume interest that...
To prospectively determine if a combined magnetic resonance (MR) protocol that includes T1-weighted dynamic contrast agent-enhanced (DCE) MR imaging, hydrogen 1 (1H) spectroscopy, and T2*-weighted perfusion imaging improves specificity in the diagnosis of breast cancer.The imaging-MR spectroscopy was performed 50 patients after positive findings at mammography but prior to biopsy. Single-voxel proton were conducted only DCE images showed rapid enhancement lesion. Biopsy results used as...
Proper grading of the cribriform prostate cancer pattern has not previously been supported by outcome-based evidence. Among 153 men who underwent radical prostatectomy, 76 with prostate-specific antigen (PSA) failure (≥0.2 ng/mL [0.2 μg/L]) were matched to 77 without failure. Frequencies high-grade patterns included fused small acini, 83.7%; papillary, 52.3%; large cribriform, 37.9%; (≤12 lumens) 17.0%; and individual cells, 22.9%. A was present in 61% (46/76) failures but 16% (12/77)...
Purpose: To prospectively evaluate the sensitivity and specificity of proton (hydrogen 1 [1H]) magnetic resonance (MR) spectroscopy for diagnosing malignant enhancing nonmass lesions identified at breast MR imaging, with histologic examination as reference standard. Materials Methods: In this HIPAA-compliant, institutional review board–approved study, in which all participants gave written informed consent, (1H) was performed suspicious or biopsy-proved that were cm larger imaging....
Prostate cancer (PCa) is a major age-related malignancy as increasing age correlates with increased risk for developing this neoplasm. Similarly, alterations in circadian rhythms have also been associated the aging population and risk. The pineal hormone melatonin known to regulate rhythms, which under control of core set genes: Period 1, 2, 3 (Per 1-3); Cryptochrome 2 (Cry 2); Clock, Bmal 2. Melatonin levels shown decrease patients exogenous exhibits antiproliferative effects against...
Pharmacokinetic analysis of dynamic contrast-enhanced magnetic resonance imaging (DCE-MRI) time-course data allows estimation quantitative parameters such as Ktrans (rate constant for plasma/interstitium contrast agent transfer), ve (extravascular extracellular volume fraction), and vp (plasma fraction). A plethora factors in DCE-MRI acquisition can affect accuracy precision these and, consequently, the utility assessing therapy response. In this multicenter challenge, acquired at one center...
The purpose is to compare quantitative dynamic contrast-enhanced (DCE) magnetic resonance imaging (MRI) metrics with tumor size for early prediction of breast cancer response neoadjuvant chemotherapy (NACT) and evaluation residual burden (RCB). Twenty-eight patients 29 primary tumors underwent DCE-MRI exams before, after one cycle of, at midpoint NACT. MRI in the longest diameter (LD) was measured according RECIST (Response Evaluation Criteria In Solid Tumors) guidelines. Pharmacokinetic...
Purpose To determine the in vitro accuracy, test‐retest repeatability, and interplatform reproducibility of T 1 quantification protocols used for dynamic contrast‐enhanced MRI at 1.5 3 T. Methods A phantom with 14 samples was imaged eight centers a common inversion‐recovery spin‐echo (IR‐SE) protocol variable flip angle (VFA) using seven angles, as well site‐specific (VFA different repetition time, proton density, Look‐Locker inversion recovery). Factors influencing accuracy (deviation from...
This multicenter study evaluated the effect of variations in arterial input function (AIF) determination on pharmacokinetic (PK) analysis dynamic contrast-enhanced magnetic resonance imaging (DCE-MRI) data using shutter-speed model (SSM). Data acquired from eleven prostate cancer patients were shared among nine centers. Each center used a site-specific method to measure individual AIF each set and submitted results managing center. These AIFs, their reference tissue-adjusted variants,...
Purpose To assess the accuracy of shutter-speed approach compared with standard dynamic contrast material–enhanced magnetic resonance (MR) imaging pharmacokinetic analysis for breast cancer diagnosis. Materials and Methods This study was approved by institutional review board HIPAA compliant. Informed consent obtained from 89 high-risk women (age range, 28–83 years) who had 92 suspicious lesions negative findings at mammography (but visible MR imaging). Each underwent a research...
Objective Recent studies have associated lower urinary tract symptoms (LUTS) in men with prostatic fibrosis, but a definitive link between collagen deposition and LUTS has yet to be demonstrated. The objective of this study was evaluate ECM content within normal glandular prostate tissue BPH, the association clinical parameters content. Methods Fibrillar assessed (48 patients) BPH nodules (24 using Masson's trichrome stain Picrosirius red stain. Second harmonic generation (SHG) imaging used...
Shutter‐speed pharmacokinetic analysis of dynamic‐contrast‐enhanced (DCE)‐MRI data allows evaluation equilibrium inter‐compartmental water interchange kinetics. The process measured here – transcytolemmal exchange is characterized by the mean intracellular molecule lifetime ( τ i ). biomarker a true intensive property not accessible any formulation tracer paradigm, which inherently assumes it effectively zero when applied to DCE‐MRI. We present population‐averaged in vivo human breast whole...
Excessive keratinocyte proliferation is thought to be responsible for the formation and development of psoriasis vulgaris. Evidence indicates that epigenetic modifications are associated with aberrant gene expression, however, nothing known about status histone in We investigated alterations patients Global H3/H4 acetylation H3K4/H3K27 methylation peripheral blood mononuclear cells from 30 psoriatic 20 healthy control subjects were quantified by EpiQuik(TM) global assay kit. The mRNA levels...
Pharmacokinetic analysis of dynamic contrast-enhanced (DCE) MRI data allows estimation quantitative imaging biomarkers such as Ktrans (rate constant for plasma/interstitium contrast reagent (CR) transfer) and ve (extravascular extracellular volume fraction). However, the use DCE-MRI in clinical practice is limited with uncertainty arterial input function (AIF) determination being one primary reasons. In this multicenter study to assess effects AIF variations on pharmacokinetic parameter...
Purpose Characterize system‐specific bias across common magnetic resonance imaging (MRI) platforms for quantitative diffusion measurements in multicenter trials. Methods Diffusion weighted (DWI) was performed on an ice‐water phantom along the superior–inferior (SI) and right–left (RL) orientations spanning ±150 mm. The same scanning protocol implemented 14 MRI systems at seven centers. estimated as a deviation of measured from known apparent coefficient (ADC) individual DWI directions....
This study investigates the effectiveness of hundreds texture features extracted from voxel-based dynamic contrast-enhanced magnetic resonance imaging (DCE-MRI) parametric maps for early prediction breast cancer response to neoadjuvant chemotherapy (NAC). In total, 38 patients with underwent DCE-MRI before (baseline) and after first 6-8 NAC cycles. Quantitative pharmacokinetic (PK) parameters semiquantitative metrics were estimated time-course data. The residual burden (RCB) index value was...
Purpose Senescence is a terminal growth arrest that functions as tumor suppressor in aging and precancerous cells response to selected anticancer compounds. Lysosomal-β-galactosidase (GLB1) hydrolyzes β-galactose from glycoconjugates the origin of senescence-associated β-gal activity (SA-β-gal). Using new GLB1 antibody, senescence biology was investigated prostate cancer (PCa) tissues. Experimental Design In vitro characterization determined primary epithelial cell cultures passaged...
Abstract We performed a phase II pharmacodynamic prevention trial of Polyphenon E [a green tea polyphenol formulation primarily consisting epigallocatechin gallate (EGCG)] in patients prior to bladder cancer surgery. Patients with tumor were randomized receive containing either 800 or 1,200 mg EGCG placebo for 14 28 days transurethral resection cystectomy. The primary objective was compare the postintervention tissue levels receiving as compared placebo. Secondary objectives included...