A5048615149- Advanced MRI Techniques and Applications
- Radiation Dose and Imaging
- Advanced Radiotherapy Techniques
- Medical Imaging Techniques and Applications
- Advanced X-ray and CT Imaging
- MRI in cancer diagnosis
- Radiation Therapy and Dosimetry
- Nuclear Physics and Applications
- Radiomics and Machine Learning in Medical Imaging
- Lanthanide and Transition Metal Complexes
- Infrared Thermography in Medicine
- Advanced X-ray Imaging Techniques
- Radiopharmaceutical Chemistry and Applications
- X-ray Spectroscopy and Fluorescence Analysis
- Advances in Oncology and Radiotherapy
- Advanced Neuroimaging Techniques and Applications
- Peripheral Nerve Disorders
- Atomic and Subatomic Physics Research
- Atomic and Molecular Physics
- Graphene and Nanomaterials Applications
- Radioactive contamination and transfer
- Electron Spin Resonance Studies
- Porphyrin and Phthalocyanine Chemistry
- Nanoparticle-Based Drug Delivery
- Boron Compounds in Chemistry
Stony Brook University
2002-2021
Evidence Based Research (United States)
2019
Stony Brook University Hospital
1999-2016
Columbia University
2012
Duke University
2011
Harlem Hospital Center
2011
Beth Israel Deaconess Medical Center
2011
State University of New York
1994-2008
Brookhaven National Laboratory
1993-2002
University of Ioannina
2002
To prospectively determine if a combined magnetic resonance (MR) protocol that includes T1-weighted dynamic contrast agent-enhanced (DCE) MR imaging, hydrogen 1 (1H) spectroscopy, and T2*-weighted perfusion imaging improves specificity in the diagnosis of breast cancer.The imaging-MR spectroscopy was performed 50 patients after positive findings at mammography but prior to biopsy. Single-voxel proton were conducted only DCE images showed rapid enhancement lesion. Biopsy results used as...
Radiotherapeutic doses for malignant gliomas are generally palliative because greater, supposedly curative would impart clinically unacceptable damage to nearby vital CNS tissues. To improve radiation treatment human gliomas, we evaluated microbeam therapy, which utilizes an array of parallel, microscopically thin (<100 microm) planar beams (microbeams) synchrotron-generated X rays. Rats with i.c. 9L gliosarcoma tumors were exposed laterally a single microbeam, 27 pm wide and 3.8 mm high,...
Abstract: We report the synthesis and characterization of a novel carbon nanostructure-based magnetic resonance imaging contrast agent (MRI CA); graphene nanoplatelets intercalated with manganese (Mn 2+ ) ions, functionalized dextran (GNP-Dex); in vitro assessment its essential preclinical physicochemical properties: osmolality, viscosity, partition coefficient, protein binding, thermostability, histamine release, relaxivity. The results indicate that, at concentrations between 0.1 100.0...
Graphene nanoplatelets (GNPs), synthesized using potassium permanganate-based oxidation and exfoliation followed by reduction with hydroiodic acid (rGNP-HI), have intercalated manganese ions within the graphene sheets, upon functionalization iodine, show excellent potential as biomodal contrast agents for magnetic resonance imaging (MRI) computed tomography (CT). Structural characterization of rGNP-HI nanoparticles low- high-resolution transmission electron microscope (TEM) showed...
Abstract Hyperpolarized 129 Xe has been used to obtain gas phase images of mouse lung in vivo , showing distinct ventilation variation as a function the breathing cycle. Spectra thorax show complex structure both (−4 3 ppm) and tissue‐dissolved (190‐205 regions. The alveolar peak shows correlated intensity frequency oscillations, attributable changes volume during breathing. two major dissolved peaks near 195‐200 ppm are attributed parenchyma blood; they reach maximum 5‐10 s decay with an...
We explored the potential for clinical research of computed tomography (CT) with monochromatic x-rays using preclinical multiple energy (MECT) system at National Synchrotron Light Source. MECT has a fixed, horizontal fan beam subject apparatus rotating about vertical axis; it will be used imaging human head and neck. Two -photodiode array detectors different spatial resolutions were used. A 10.5 cm diameter acrylic phantom was imaged 43 keV conventional CT (CCT) 80 kVp: resolution line pairs...
High resolution spatial details of the distribution activity in three dimensions is required to evaluate localization and dosimetric properties radiolabelled monoclonal antibodies tumors normal tissues. Planar imaging small animals with a 5-10 mm usually modality choice. The authors investigated high single-photon emission computed tomographic (SPECT) imaging, based on rotating pinhole scintillation camera. Although sensitivity collimator low, several radionuclides offer suitable decay...
The potential for malignancy detection using dynamic infrared imaging (DIRI) has been investigated in an animal model of human malignancy. Malignancy was apparent images formed at the vasomotor and cardiogenic frequencies tumour bearing mice. observation removed by administration agent that blocks vasodilation caused nitric oxide (NO). Image patterns similar to those characterize could be mimicked normal mice NO producing agent. Apparently DIRI allows cancer this through generated NO....
Fetal Radiation Dose During Gestation Estimated on an Anthropomorphic Phantom for Three Generations of CT ScannersAnthony G. Gilet1, Jared M. Dunkin, Thomas J. Fernandez, Terry Button and Nancy E. BudorickAudio Available | Share
Centers for Disease Control and Prevention Diabetes Program recognition requires successful program completion by a cohort of at least five people with prediabetes. Such programs have generally been "in-person" provided qualified coach from recognized program. A 10 patients prediabetes was enrolled in physician's office to use the cloud-based Type II Module an effort achieve recognition. supported physician coach. The purpose this article is evaluate performance relative behavior stages...
Total L-shell x-ray production cross sections have been measured for thin solid targets of atomic number, Z2 = 31, 33, 34, 35 and 55 11H 42He ions at the same energy/mass. Absolute section ratios are compared to theoretical predictions plane wave Born approximation perturbed stationary state theory with Coulomb deflection an approximate relativistic correction.
AbstractHigh-resolution, non-invasive, 3D-imaging techniques would greatly benefit the investigation of localization properties tumor-specific radiopharmaceuticals in laboratory animals. The present study reports how pinhole SPECT can be applied to tumor studies small animals provide high resolution images vivo. Pinhole was performed using a rotating scintillation camera, equipped with collimator. sensitivity 2 mm diameter collimator at 45 from source is 90 cps/MBq for 99mTc. planar spatial...
Purpose: The purpose of this study was to retrospectively evaluate dynamic contrast enhanced (DCE) breast magnetic resonance imaging (MRI) data. Texture analysis is applied extract features from data and test the feasibility using these texture for creating a computer aided diagnostic system (CAD). Methods: Computation time feature extraction entire 3D dataset precludes whole analysis. Reduction can be best accomplished through generation angiogenesis (parametric maps) based on agent...