A5035063853- Advanced MRI Techniques and Applications
- Cardiac Imaging and Diagnostics
- NMR spectroscopy and applications
- Advanced Neuroimaging Techniques and Applications
- Corneal surgery and disorders
- Advanced X-ray and CT Imaging
- Cerebrovascular and Carotid Artery Diseases
- Corneal Surgery and Treatments
- Medical Imaging Techniques and Applications
- Acute Ischemic Stroke Management
- Venous Thromboembolism Diagnosis and Management
- Glaucoma and retinal disorders
- Lung Cancer Diagnosis and Treatment
- Advanced X-ray Imaging Techniques
- Mechanical and Optical Resonators
- Neurotransmitter Receptor Influence on Behavior
- Acoustic Wave Resonator Technologies
- Advanced Radiotherapy Techniques
- Microfluidic and Bio-sensing Technologies
- Radiation Dose and Imaging
- Cerebral Venous Sinus Thrombosis
- Memory and Neural Mechanisms
- Intracerebral and Subarachnoid Hemorrhage Research
- Skin Protection and Aging
- Ocular Surface and Contact Lens
University College London
2022
Aarhus University
2020
Reprogenetics
2017
Diagnostics For All
2016
Radboud University Nijmegen
2016
Radboud University Medical Center
2016
University of Pennsylvania
2015
Veracyte (United States)
2015
Burlington College
2010
Epix Pharmaceuticals (United States)
2004-2009
In the present study, we tested hypothesis that a carbohydrate-protein (CHO-Pro) supplement would be more effective in replenishment of muscle glycogen after exercise compared with carbohydrate equal content (LCHO) or caloric equivalency (HCHO). After 2.5 ± 0.1 h intense cycling to deplete stores, subjects ( n = 7) received, using rank-ordered design, CHO-Pro (80 g CHO, 28 Pro, 6 fat), LCHO HCHO (108 fat) immediately (10 min) and 2 postexercise. Before during 4 recovery, vastus lateralis was...
Plaque rupture with subsequent thrombosis is recognized as the underlying pathophysiology of most acute coronary syndromes and stroke. Thus, direct thrombus visualization may be beneficial for both diagnosis guidance therapy. We sought to test feasibility imaging subacute using MRI together a novel fibrin-binding gadolinium-labeled peptide, EP-1873, in an experimental animal model plaque thrombosis.Fifteen male New Zealand White rabbits (weight, approximately 3.5 kg) were made...
Abstract Oscillating gradients were used to probe the diffusion‐time/frequency dependence of water diffusion in gray matter normal and globally ischemic rat brain. In terms a conventional definition time, oscillating gradient measurements provided apparent coefficient (ADC) with times between 9.75 ms 375 μs, an order magnitude shorter than previously studied vivo. Over this range, ADCs increased as much 24% vivo 50% postmortem, depending on nature waveform used. Novel waveforms employed...
The advent of fibrin-binding molecular magnetic resonance (MR) contrast agents and advances in coronary MRI techniques offers the potential for direct imaging thrombosis. We tested feasibility this approach using a gadolinium (Gd)-based agent, EP-2104R (EPIX Medical Inc), swine model thrombus in-stent thrombosis.Ex vivo sensitivity MR was by use intracoronarily delivered Gd-DTPA-labeled fibrinogen thrombi (n=6). After successful demonstration, thrombosis induced x-ray-guided placement...
To determine the feasibility of detecting thrombi using a fibrin-specific gadolinium-based magnetic resonance imaging contrast agent, EP-2104R.Subjects with confirmed thrombus in venous system (n = 14), or heart, arterial 38) were enrolled. Patients imaged before and at various times following 4 mumol/kg intravenous bolus injection EP-2104R: <1 hour (N 16), 2 to 6 hours 36), and/or 20 36 33). Images assessed by investigators each site single reader not affiliated sites whether visible,...
Background— The differential diagnosis of acute chest pain is challenging, especially in patients with normal ECG findings, and may include coronary thrombosis or pulmonary emboli. aim this study was to investigate the novel fibrin-specific contrast agent EP-2104R for molecular targeted MR imaging Methods Results— Fresh clots were engineered ex vivo from human blood delivered lungs arteries 7 swine. Subsequent performed a navigator-gated free-breathing cardiac-triggered 3D inversion-recovery...
The detection and differentiation of intracardiac masses is still challenging may include neoplasms thrombi. aim this study was the investigation a targeted, fibrin-specific contrast agent (EP-2104R) for molecular targeted magnetic resonance imaging (MRI) left atrial clots.Chronic human thrombi were surgically implanted in appendage 5 swine. Molecular MRI performed with navigator-gated, free-breathing, cardiac-triggered 3D inversion-recovery, black-blood, gradient-echo sequence before after...
We explored the potential for clinical research of computed tomography (CT) with monochromatic x-rays using preclinical multiple energy (MECT) system at National Synchrotron Light Source. MECT has a fixed, horizontal fan beam subject apparatus rotating about vertical axis; it will be used imaging human head and neck. Two -photodiode array detectors different spatial resolutions were used. A 10.5 cm diameter acrylic phantom was imaged 43 keV conventional CT (CCT) 80 kVp: resolution line pairs...
Abstract The theory of temporal diffusion spectra is reviewed. In contrast to q ‐space spectroscopy, which measures the displacement spectrum spins in a spatial domain, spectral density velocity correlation function (VCF) domain considered. It demonstrated that casting this may facilitate measurements microscopic geometry and decomposition signal into components due disperse flow restricted diffusion. An oscillating gradient (OG) method spectroscopy was developed implemented. Microscopic...
Imaging of cerebral vein thrombosis is still challenging. Currently, diagnosis based on CT venography and MRI including MRA conventional digital subtraction angiography. However, especially in chronic cases, each method has shown its limitations. Newer strategies for are found molecular imaging using targeted contrast agents. The aim this study was to prove the feasibility a novel fibrin-targeted MR agent (EP-2104R; EPIX Pharmaceuticals) selective sinus venous an animal model.Thrombosis...
Molecular targeted MR imaging of human clots material in a model pulmonary embolism using fibrin-specific magnetic resonance contrast agent (EP-2104R, EPIX Pharmaceuticals, Cambridge, MA).Fresh ex vivo engineered thrombi (human blood) and removed from patients were delivered 11 swine. with 3D gradient-echo [3D fast field echo (3DFFE)] sequence navigator-gated cardiac-triggered inversion-recovery black-blood (IR) was performed before thrombus delivery, after delivery but media application, 2...
<h3>Importance</h3> An oral treatment for neovascular age-related macular degeneration would be less burdensome than repeated intravitreous injections. X-82 is an tyrosine kinase inhibitor active against vascular endothelial growth factor (VEGF) and platelet-derived factor. <h3>Objective</h3> To undertake safety testing of administered the AMD. <h3>Design, Setting, Participants</h3> Phase 1, open-label, uncontrolled, dose-escalation study at 5 US retinal clinics between November 2012 March...
BackgroundBronchoscopy is often the initial diagnostic procedure performed in patients with pulmonary lesions suggestive of lung cancer. A bronchial genomic classifier was previously validated to identify at low risk for cancer after an inconclusive bronchoscopy. In this study, we evaluated potential reduce invasive utilization suspected cancer.MethodsIn two multicenter trials undergoing bronchoscopy cancer, measured normal-appearing epithelial cells from a mainstem bronchus. Among and...
The detection of pulmonary embolism is still challenging due to the often nonspecific clinical findings. aim this study was investigate potential molecular targeted magnetic resonance imaging (MRI) emboli using low-dose application a fibrin-specific contrast agent (EP-2104R; Epix Pharmaceuticals, Cambridge, MA).Fresh clots from human blood were engineered ex vivo and delivered in lungs 11 swine. Subsequently, T1-weighted breath-hold three-dimensional gradient-echo sequence performed before...
The aim of this study was to investigate the use a fibrin-specific contrast agent (EP-2104R, EPIX Pharmaceuticals, Lexington, Massachusetts, USA) for targeted molecular magnetic resonance (MR) imaging human clot material removed from patients in model coronary thrombosis swine.Freshly ex vivo engineered clots blood and situ developed were delivered into arteries nine domestic swine. For MR navigator-gated, free-breathing, cardiac-triggered 3D inversion recovery black-blood gradient echo...
The purpose of this study was to evaluate the safety and efficacy gadofosveset, a gadolinium-based albumin-binding MRI contrast agent, in patients with pedal arterial disease.A total 185 adult known or suspected disease were randomized group receiving 0.03 mmol/kg 0.05 gadofosveset for MR angiography arteries. Gadofosveset-enhanced unenhanced time-of-flight angiograms compared conventional angiograms, standard reference, presence vascular stenosis. All underwent drug analysis.For each three...
PRX-00023, a serotonin 1A receptor agonist, was designed to provide high potency and selectivity for its target. To assess the possible therapeutic utility in anxiety, randomized, double-blind, placebo-controlled trial conducted 311 subjects who met criteria of Diagnostic Statistical Manual Mental Disorders, Fourth Edition, generalized anxiety disorder. All underwent 1-week placebo run-in were randomized receive once-daily capsules containing either PRX-00023 (80 mg/d) or an additional 8...
To prospectively assess the accuracy of contrast-enhanced MR angiography aortoiliac arteries using blood pool agent Vasovist compared to unenhanced time-of-flight MRA. Conventional digital subtraction served as standard reference.Twenty-nine patients with suspected or known peripheral arterial occlusive disease (PAOD) were examined by means a dosage 0.03 mmol/kg bodyweight Vasovist. Unenhanced two-dimensional (TOF) MRA same anatomic region was performed immediately prior injection contrast...
Purpose: The purpose of this study was to assess the safety, tolerability, dosing, and efficacy active 19 amino acid fragment lacritin (Lacripep), a broad regulator ocular surface homeostasis, in treatment disease associated with primary Sjögren syndrome. Methods: Two hundred four subjects were randomized receive vehicle, 22 μM Lacripep, or 44 Lacripep 3 times daily for 28 days, preceded by 14-day run-in followed washout. Outcome measures corneal fluorescein staining (CFS), lissamine...
Abstract Substance use disorders (SUDs) are characterized by a compulsion to seek and consume one or more substances of abuse, with perceived loss control negative emotional state. Repeated substance results in synaptic morphological changes, secondary toxicity SUD pathology the dopamine striato-thalamo-cortical limbic pathways. These neuroadaptations seem vary between studies, which could be related divergent effects substances, consumption severity other unknown factors. We therefore...