A5003630137- Lung Cancer Diagnosis and Treatment
- Tracheal and airway disorders
- Inhalation and Respiratory Drug Delivery
- Airway Management and Intubation Techniques
- Lung Cancer Treatments and Mutations
- Pleural and Pulmonary Diseases
- Respiratory Support and Mechanisms
- Medical Imaging and Pathology Studies
- Tuberculosis Research and Epidemiology
- Neonatal Respiratory Health Research
- Chronic Obstructive Pulmonary Disease (COPD) Research
- Radiomics and Machine Learning in Medical Imaging
- Trauma Management and Diagnosis
- Salivary Gland Tumors Diagnosis and Treatment
- Orthopedic Surgery and Rehabilitation
- Cancer Genomics and Diagnostics
- Lung Cancer Research Studies
- Voice and Speech Disorders
- Respiratory and Cough-Related Research
- Surgical Simulation and Training
- Mycobacterium research and diagnosis
- Transplantation: Methods and Outcomes
- Peripheral Nerve Disorders
- Photodynamic Therapy Research Studies
- Cancer Cells and Metastasis
University of Wisconsin Carbone Cancer Center
2017-2025
University of Wisconsin–Madison
2013-2023
UW Health University Hospital
2022
University of Pennsylvania
2017
Highland Community College - Illinois
2016
South West London and St George's Mental Health NHS Trust
2011-2014
St George’s University Hospitals NHS Foundation Trust
2011-2014
Wisconsin Institutes for Discovery
2013
Saint Louis University Hospital
2010
University of Iowa
1996-2009
Bronchoscopy is frequently nondiagnostic in patients with pulmonary lesions suspected to be lung cancer. This often results additional invasive testing, although many are benign. We sought validate a bronchial-airway gene-expression classifier that could improve the diagnostic performance of bronchoscopy.Current or former smokers undergoing bronchoscopy for cancer were enrolled at 28 centers two multicenter prospective studies (AEGIS-1 and AEGIS-2). A was measured epithelial cells collected...
<h3>Importance</h3> Preliminary clinical trials have demonstrated that endobronchial coils compress emphysematous lung tissue and may improve function, exercise tolerance, symptoms in patients with emphysema severe hyperinflation. <h3>Objective</h3> To determine the effectiveness safety of coil treatment. <h3>Design, Setting, Participants</h3> Randomized trial conducted among 315 air trapping recruited from 21 North American 5 European sites December 2012 through November 2015....
The NCCN Guidelines for Lung Cancer Screening recommend criteria selecting individuals screening and provide recommendations evaluation follow-up of lung nodules found during initial subsequent screening. These Insights focus on recent updates to the Screening.
The NCCN Clinical Practice Guidelines in Oncology (NCCN Guidelines) for Lung Cancer Screening provide criteria selecting individuals screening and offer recommendations evaluating managing lung nodules detected during initial subsequent annual screening. These Insights focus on recent updates to the Screening.
Abstract Surfactant protein-D (SP-D) is a collectin produced in the distal lung airspaces that believed to play an important role innate pulmonary immunity. Naive immunologic responses Mycobacterium tuberculosis (M.tb) are especially lung, since entry of this inhaled pathogen into alveolar macrophage pivotal event disease pathogenesis. Here we investigated SP-D binding M.tb and effect on adherence human macrophages. These studies demonstrate specific saturable, calcium dependent,...
Background. Quality problems in medical care are not a new finding. Variations practice as well actual errors have been pointed out for many decades. The current movement to write guidelines attempt correct these deviations from recommended has solved the problem. Objectives. In order gain greater acceptance of and change behavior health providers, science guideline implementation must be understood better. Research Design. A group experts who studied problem Europe United States was...
In high concentrations of fresh nonimmune human serum, Mycobacterium tuberculosis activates the alternative pathway complement and binds C3 protein, resulting in enhanced phagocytosis by receptors on alveolar macrophages. Yet lung, is relatively inactive compared to classical pathway. To begin determine whether opsonophagocytosis M. macrophages can occur lung immunologically naive host, we characterized binding different serum concentrated bronchoalveolar lavage fluid. Here show that rapid,...
The gene expression profile of cytologically-normal bronchial airway epithelial cells has previously been shown to be altered in patients with lung cancer. Although bronchoscopy is often used for the diagnosis cancer, its sensitivity imperfect, especially small and peripheral suspicious lesions. In this study, we derived a classifier from that detects presence cancer current former smokers undergoing suspect evaluated detect among an independent cohort.We collected (BECs) mainstem bronchus...
ABSTRACT Lung surfactant protein D (SP-D) binds to Mycobacterium tuberculosis surface lipoarabinomannan and results in bacterial agglutination, reduced uptake, inhibition of growth human macrophages. Here we show that SP-D limits the intracellular bacilli macrophages by increasing phagosome-lysosome fusion but not generating a respiratory burst.
Abstract The innate immune system in the lung is essential for controlling infections due to inhaled pathogens. Mycobacterium tuberculosis (M.tb) encounters components of when into lung, but consequences these interactions are poorly understood. Surfactant protein D (SP-D) binds and agglutinates M.tb bacilli, reduces uptake bacteria by human macrophages. In current studies, we utilized a recombinant SP-D variant (CDM) that lacks collagen domain further characterize interaction with M.tb,...
Abstract Alveolar macrophages are important host defense cells in the human lung that continuously phagocytose environmental and infectious particles invade alveolar space. prototypical alternatively activated macrophages, with up-regulated innate immune receptor expression, down-regulated costimulatory molecule limited production of reactive oxygen intermediates (ROI) response to stimuli. Surfactant protein A (SP-A) is an abundant pulmonary surfactant has been shown alter several macrophage...
BackgroundBronchoscopy is often the initial diagnostic procedure performed in patients with pulmonary lesions suggestive of lung cancer. A bronchial genomic classifier was previously validated to identify at low risk for cancer after an inconclusive bronchoscopy. In this study, we evaluated potential reduce invasive utilization suspected cancer.MethodsIn two multicenter trials undergoing bronchoscopy cancer, measured normal-appearing epithelial cells from a mainstem bronchus. Among and...
Abstract Objectives: Laryngotracheostenosis (LTS) is a condition in which the airway narrowed between vocal cords and carina. We seek to examine whether flexible bronchoscopy with neodymium‐doped yttrium aluminum garnet (Nd:YAG) laser incision balloon dilation tracheoplasty practical choice management of patients subglottic or tracheal stenosis. Methods: A retrospective chart review was performed at tertiary care hospital. All subjects laryngotracheostenosis treated January 1, 2000, April...
Lung cancer is the leading cause of cancer-related deaths in United States and worldwide. This has led to major research initiatives focusing on improving early diagnosis rate, as well development pharmacodynamic biomarkers. However, broad clinical integration these approaches limited due invasive nature lung biopsies, needle aspirates resections. Recently, an advance for sampling suspicious nodules collect mini-bronchoalveolar lavage (mBAL) samples was shown be diagnostically relevant but...
Nerve compression syndromes may cause postburn morbidity that can often be difficult to recognize and manage. This study reviewed patients in the authors' institution who needed nerve decompression secondary thermal or electrical burns. The objective was evaluate timing of burn population. A 4-year review institution's database found 22 underwent peripheral neuroplasty. patient population included both patients. Two were excluded from because they rapid forearm amputation, a third had his...
Current medical society guidelines recommend a procedural number for obtaining electromagnetic navigational bronchoscopy (ENB) competency and institutional volume training.To assess learning curves estimate the of ENB procedures interventional pulmonology (IP) fellows to reach competency.We conducted prospective multicenter study IP in United States ENB. A tool previously validated similar population was used by their local faculty two blinded independent reviewers using virtual recording...
Various methods for ablating peripheral lung lesions are being investigated; however, none have been successfully adapted delivery via bronchoscopy. Vapor ablation is currently used to bronchoscopically create volume reduction in emphysema patients.In this study, an adaptation of that technology evaluated potential treatment a live pig model.In 5 anesthetized healthy pigs, vapor varying energy levels was delivered 66 different subsegments with airway diameters 2-5 mm. Two hours after...
Bronchoscopy is frequently used for the evaluation of suspicious pulmonary lesions found on computed tomography, but its sensitivity detecting lung cancer limited. Recently, a bronchial genomic classifier was validated to improve bronchoscopy detection, demonstrating high and negative predictive value among patients at intermediate risk (10–60 %) with an inconclusive bronchoscopy. Our objective this study determine if result that down-classifies patient from low (<10 would reduce rate...
Newer navigational bronchoscopy technologies render peripheral lung lesions accessible for biopsy and potential treatment. We investigated whether photodynamic therapy (PDT) delivered via is feasible safe ablation of tumors.Two studies evaluated PDT in patients with solid tumors followed by clinical follow-up (nonresection study, N=5) or lobectomy (resection N=10). Porfimer sodium injection was administered 40 to 50 hours before bronchoscopy. Lesion location confirmed radial probe...