A5022576322- Medical Imaging Techniques and Applications
- Radiopharmaceutical Chemistry and Applications
- Advanced Radiotherapy Techniques
- Neuroendocrine Tumor Research Advances
- Radiomics and Machine Learning in Medical Imaging
- Lung Cancer Research Studies
- Neuroblastoma Research and Treatments
- Advanced X-ray and CT Imaging
- Radioactive Decay and Measurement Techniques
- Radiation Therapy and Dosimetry
- Radiation Dose and Imaging
- Advanced MRI Techniques and Applications
- Thyroid Cancer Diagnosis and Treatment
- Radiation Detection and Scintillator Technologies
- Hepatocellular Carcinoma Treatment and Prognosis
- Medical Imaging and Pathology Studies
- Atomic and Subatomic Physics Research
- Lung Cancer Treatments and Mutations
- Medical Image Segmentation Techniques
- Lymphoma Diagnosis and Treatment
- Lung Cancer Diagnosis and Treatment
- Advances in Oncology and Radiotherapy
- Advanced Semiconductor Detectors and Materials
- Monoclonal and Polyclonal Antibodies Research
- Effects of Radiation Exposure
Lund University
2015-2024
Royal Marsden Hospital
2017
Mylan (Switzerland)
2013
The accuracy of absorbed dose calculations in personalized internal radionuclide therapy is directly related to the activity (or concentration) estimates obtained at each imaging time points. MIRD Pamphlet no. 23 presented a general overview methods that are required for quantitative SPECT imaging. present document next series isotope-specific guidelines and recommendations follow information was provided 23. This paper focuses on <sup>177</sup>Lu (lutetium) its application...
To present data from an interim analysis of a Phase II trial designed to determine the feasibility, safety, and efficacy individualising treatment based on renal dosimetry, by giving as many cycles possible within maximum biologically effective dose (BED).Treatment was given with repeated 7.4 GBq 177Lu-DOTATATE at 8-12-week intervals. Detailed dosimetry performed in all patients after each cycle using hybrid method (SPECT + planar imaging). All received up BED 27 ± 2 Gy (α/β = 2.6 Gy) (Step...
A framework is proposed for modelling the uncertainty in measurement processes constituting dosimetry chain that are involved internal absorbed dose calculations. The starting point basic model a site of interest as product cumulated activity and factor. In turn, given by area under time–activity curve derived from time sequence values. Each value obtained terms count rate, calibration factor recovery coefficient (a correction partial volume effects). method to determine factor, both which...
The purpose of the EANM Dosimetry Committee is to provide recommendations and guidance scientists clinicians on patient-specific dosimetry. Radiopharmaceuticals labelled with lutetium-177 (177Lu) are increasingly used for therapeutic applications, in particular treatment metastatic neuroendocrine tumours using ligands somatostatin receptors prostate adenocarcinoma small-molecule PSMA-targeting ligands. This paper provides an overview reported dosimetry data these therapies summarises current...
Abstract BACKGROUND: 177 Lu‐(DOTA0,Tyr3) octreotate is a new treatment modality for disseminated neuroendocrine tumors. According to consensus protocol, the calculated maximally tolerated absorbed dose kidney should not exceed 27 Gy. In commonly used dosimetry methods, planar imaging determination of residence time, whereas mass determined from computed tomography (CT) scan. METHODS: Three different quantification methods were evaluate kidneys. The first method involved common activity...
Abstract The aim of this standard operational procedure is to standardize the methodology employed for evaluation pre- and post-treatment absorbed dose calculations in 90 Y microsphere liver radioembolization. Basic assumptions include permanent trapping microspheres, local energy deposition method voxel dosimetry, patient–relative calibration activity quantification.The identity 99m Tc albumin macro-aggregates (MAA) biodistribution also assumed. large observed discrepancies some patients...
Radiopharmaceutical therapy (RPT) is a radiation delivery modality that uses radionuclides to irradiate tissues with various forms of ionizing radiation. In most RPT, the radionuclide targeted diseased tissue following systemic administration pharmaceutical circulates throughout body and delivers sites radiopharmaceutical accumulation. Three major classes are used in RPT including beta-particle emitters, alpha-particle Auger-electron emitters. Recent therapeutic successes regulatory approval...
Abstract Purpose Radionuclide therapy with 177 Lu-DOTATATE is well established for patients advanced somatostatin receptor–positive neuroendocrine tumors a standard schedule of 7.4 GBq at four occasions. However, this approach does not consider individual variability affecting the tumor radiation dose or to organs risk. Therefore, it important assess more personalized strategies. The aim phase II trial was evaluate individualized which number cycles varied based on renal dosimetry. Methods...
In SPECT imaging of pure beta emitters, such as 90Y, the acquired spectrum is very complex, which increases demands on protocol and reconstruction. this work, we have evaluated quantitative accuracy bremsstrahlung with focus reconstruction algorithm including model-based attenuation, scatter collimator–detector response (CDR) compensations. The CDR compensation methods require pre-calculated point-spread functions, were generated SIMIND MC program. program dedicated for simulation...
Background. Dosimetry in radionuclide therapy estimates delivered absorbed doses to tumours and ensures that dose levels normal organs are below tolerance levels. One procedure is determine time-activity curves volumes-of-interests from which the estimated using SPECT with appropriate corrections for attenuation, scatter collimator response. From corrected images energy can be calculated by (a) assuming kinetic deposited same voxel where particles were emitted, (b) convolve point-dose...
The European directive on basic safety standards (Council 2013/59 Euratom) mandates dosimetry-based treatment planning for radiopharmaceutical therapies. comes into operation February 2018, and the aim of a report produced by Internal Dosimetry Task Force Association Nuclear Medicine is to address this aspect directive. A summary presented. brief review five most common therapy procedures included in current text, focused potential perform patient-specific dosimetry. In full report, 11...
Currently, the implementation of dosimetry in molecular radiotherapy (MRT) is not well investigated, and view Council Directive (2013/59/Euratom), there a need to understand current availability dosimetry-based MRT clinical practice research studies. The aim this study was assess across European countries. An electronic questionnaire distributed This addressed 18 explicitly considered therapies, for each therapy, similar set questions were included. Questions covered number patients...
Recently, 177Lu-dotatate therapy for neuroendocrine tumours has received regulatory approval. Dosimetry can be used to optimize treatment on an individual basis, but there is no international consensus as how it should done. The aim of this study determine a feasible and accurate dosimetry method guide individualized peptide receptor radionuclide (PRRT) patients with tumours. As part clinical trial therapy, renal was performed all in each cycle, using hybrid planar-SPECT/CT method. In the...
This study aimed to compare different image-based methods for bone marrow dosimetry and the dose–response relationship during treatment with <sup>177</sup>Lu-DOTATATE in patients without skeletal metastases. <b>Methods:</b> included 46 advanced neuroendocrine tumors treated at least 2 fractions of Sahlgrenska University Hospital. High- low-uptake compartments were automatically outlined planar images collected 2, 24, 48, 168 h after injection. The absorbed doses calculated from cross high-...
Abstract Purpose Patient-specific dosimetry is required to ensure the safety of molecular radiotherapy and predict response. Dosimetry involves several steps, first which determination activity radiopharmaceutical taken up by an organ/lesion over time. As uncertainties propagate along each subsequent steps (integration time–activity curve, absorbed dose calculation), establishing a reliable quantification essential. The MRTDosimetry project was European initiative bring together expertise in...
Tumor dosimetry was performed for 177Lu-DOTATATE with the aims of better understanding range and variation tumor-absorbed doses (ADs), how different dosimetric quantities evolve over treatment cycles, whether this evolution differs depending on tumor grade. Such information is important radiobiologic interpretation may inform design alternative administration schemes. Methods: The data came from 41 patients neuroendocrine tumors (NETs) grade 1 (n = 23) or 2 18) who had received between 9...
Peptide receptor radionuclide therapy presents the possibility of tracing and quantifying uptake drug in body performing dosimetry, potentially allowing individualization treatment schemes. However, details how neuroendocrine tumors (NETs) respond to different absorbed doses are insufficiently known. Here, we investigated relationship between tumor-absorbed dose tumor response a cohort patients with NETs treated [<sup>177</sup>Lu]Lu-DOTATATE. <b>Methods:</b> This was retrospective study...
A computer model of a patient-specific clinical 177Lu-DOTATATE therapy dosimetry system is constructed and used for investigating the variability renal absorbed dose biologically effective (BED) estimates. As patient models, three anthropomorphic phantoms coupled to pharmacokinetic are used. Aspects included in dosimetry-process gamma-camera calibration via measurement sensitivity, selection imaging time points, generation mass-density maps from CT, SPECT imaging, volume-of-interest...
This feasibility study demonstrates <sup>90</sup>Y quantitative bremsstrahlung imaging of patients undergoing high-dose myeloablative <sup>90</sup>Y-ibritumomab treatment. <b>Methods:</b> The includes pretherapy <sup>111</sup>In SPECT/CT and planar whole-body (WB) at 7 d therapy 6 WB 1 d. Time–activity curves organ-absorbed doses derived from SPECT images were compared with estimates. Organ activities the first day corresponding <b>Results:</b> Pretherapy 3 similar to images. Differences...