A5039659665- Medical Imaging Techniques and Applications
- Advanced Radiotherapy Techniques
- Radiopharmaceutical Chemistry and Applications
- Radiomics and Machine Learning in Medical Imaging
- Radiation Dose and Imaging
- Radiation Therapy and Dosimetry
- Advanced X-ray and CT Imaging
- Advances in Oncology and Radiotherapy
- Cervical Cancer and HPV Research
- Neuroendocrine Tumor Research Advances
- Neuroblastoma Research and Treatments
- Advanced MRI Techniques and Applications
- Calibration and Measurement Techniques
- Radioactive Decay and Measurement Techniques
- Electron and X-Ray Spectroscopy Techniques
- Nuclear Physics and Applications
- Cardiac Imaging and Diagnostics
- Lymphoma Diagnosis and Treatment
- Lung Cancer Research Studies
University of Modena and Reggio Emilia
2024
Policlinico di Modena
2023-2024
Azienda Sanitaria Unità Locale di Reggio Emilia
2018-2023
Istituti di Ricovero e Cura a Carattere Scientifico
2017-2023
University of Bologna
2017-2023
Tecnologie Avanzate (Italy)
2022
Royal Marsden NHS Foundation Trust
2020
University of Milan
2018
Ospedale Santa Maria
2017
National Physical Laboratory
2017
Abstract Purpose Patient-specific dosimetry is required to ensure the safety of molecular radiotherapy and predict response. Dosimetry involves several steps, first which determination activity radiopharmaceutical taken up by an organ/lesion over time. As uncertainties propagate along each subsequent steps (integration time–activity curve, absorbed dose calculation), establishing a reliable quantification essential. The MRTDosimetry project was European initiative bring together expertise in...
Internal dosimetry evaluation consists of a multi-step process ranging from imaging acquisition to absorbed dose calculations. Assessment uncertainty is complicated and, for that reason, it commonly ignored in clinical routine. However, essential adequate interpretation the results. Recently, EANM published practical guidance on analysis molecular radiotherapy based application law propagation uncertainty. In this study, we investigated overall sample patient following guidelines. The aim...
Peptide receptor radionuclide therapy (PRRT) is an effective therapeutic option in patients with metastatic neuroendocrine tumor (NET). However, PRRT fails about 15-30% of cases. Identification biomarkers predicting the response to essential for treatment tailoring. We aimed evaluate predictive and prognostic role semiquantitative volumetric parameters obtained from 68Ga-DOTATOC PET/CT before (bPET) after two cycles (iPET). A total 46 were included this retrospective analysis. The primary...
The present work concerns the comparison of performances three systems for dosimetry in RPT that use different techniques absorbed dose calculation (organ-level dosimetry, voxel-level kernel convolution and Monte Carlo simulations). aim was to assess importance choice most adequate modality, providing recommendations about computation tool.The were evaluated both on phantoms patients a multi-level approach. Different filled with 177Lu-radioactive solution used: homogeneous cylindrical...
18F-FDG PET/CT imaging allows to study oncological patients and their relative diagnosis through the standardised uptake value (SUV) evaluation. During radiopharmaceutical injection, an extravasation event may occur, making SUV less accurate possibly leading severe tissue damage. The aimed propose a new technique monitor manage these events, provide early evaluation correction estimated coefficient.A cohort of 70 undergoing 18F- FDG examinations was enrolled. Two portable detectors were...
Abstract Background: Internal dosimetry evaluation consists of a multi-step process ranging from imaging acquisition to absorbed dose calculations. Assessment uncertainty is complicated and, for that reason, it commonly ignored in clinical routine. However, essential adequate interpretation the results. Recently, EANM published practical guidance on analysis molecular radiotherapy based application law propagation uncertainty. In this study, we investigated overall sample patient following...
In Internal Radiotherapy, radiopharmaceutical dosimetry provides an accurate estimation of absorbed radiation doses to organs at risk and tumours. this paper Velocity Theranostics (Varian Medical Systems), is investigated. Its performances are compared OLINDA 2.0 in both anthropomorphic phantom a group patients. was evaluated with cohort patients (15) treated 177Lu radiolabelled peptides. The were calculated for the liver, spleen kidneys, separately using same set images. To reduce...
Commissioning, calibration, and quality control procedures for nuclear medicine imaging systems are typically performed using hollow containers filled with radionuclide solutions. This leads to multiple sources of uncertainty, many which can be overcome by traceable, sealed, long-lived surrogate containing a comparable energies emission probabilities. study presents the results quantitative SPECT/CT comparison exercise within MRTDosimetry consortium assess feasibility 133Ba as 131I imaging....
This work shows the effectiveness of Monte Carlo methods for calibrating a dual-energy CT (DECT) system on heterogeneous phantom radiotherapy. The reference comprising 20 inserts different materials and densities representing human tissues inserted in plastic water cylinder has been considered. reliability model, built with Penelope code, verified by comparing results simulations at 80[Formula: see text]kVp 140[Formula: experimental data acquired from scans dosimetry measurements. effective...
Abstract Commissioning, calibration, and quality control procedures for nuclear medicine imaging systems are typically performed using hollow containers filled with radionuclide solutions. This leads to multiple sources of uncertainty, many which can be overcome by traceable, sealed, long-lived surrogate containing a comparable energies emission probabilities. study presents the results quantitative SPECT/CT comparison exercise within MRTDosimetry consortium assess feasibility 133 Ba as 131...
Background Image guided brachytherapy is well-established for the treatment of gynaecological cancers.ICRU Report 89 recommends delineating target volume on MR to utilise superior tumour visualisation.At our centre, a para-axial T2 volumetric image taken after applicator insertion fused with CT enable HR-CTV be transferred organs at risk contouring and planning.This process needs accurate streamlined.The fusion functionality from three commercially available programmes were analysed...
Abstract Background Internal dosimetry evaluation consists of a multi-step process ranging from imaging acquisition to absorbed dose calculations. Assessment uncertainty is complicated and, for that reason, it commonly ignored in clinical routine. However, essential adequate interpretation the results. Recently, EANM published practical guidance on analysis molecular radiotherapy based application law propagation uncertainty. In this study, we investigated overall large sample patient...
Abstract Background: Internal dosimetry evaluation consists of a multi-step process ranging from imaging acquisition to absorbed dose calculations. Assessment uncertainty is complicated and, for that reason, it commonly ignored in clinical routine. However, essential adequate interpretation the results. Recently, EANM published practical guidance on analysis molecular radiotherapy based application law propagation uncertainty. In this study, we investigated overall sample patient following...
<title>Abstract</title> Background<sup>18</sup>F-FDG PET/CT imaging allows to study oncological patients and their relative diagnosis through the Standardized Uptake Value (SUV) evaluation. During radiopharmaceutical injection, an extravasation event may occur, making SUV value less accurate possibly leading severe tissue damage. The aim of was propose a new technique monitor manage these events, in order evaluate correction calculated value. Methods A cohort 70 undergoing<sup>18</sup>F- FDG...