A5045511356- Medical Imaging Techniques and Applications
- Radiomics and Machine Learning in Medical Imaging
- Cancer, Hypoxia, and Metabolism
- Glioma Diagnosis and Treatment
- Advanced MRI Techniques and Applications
- MRI in cancer diagnosis
- Radiopharmaceutical Chemistry and Applications
- Pharmacological Effects and Toxicity Studies
- Breast Cancer Treatment Studies
- Drug Transport and Resistance Mechanisms
- Bone health and treatments
- Lanthanide and Transition Metal Complexes
- Advanced X-ray and CT Imaging
- Advanced Radiotherapy Techniques
- Lung Cancer Treatments and Mutations
- Nanoplatforms for cancer theranostics
- Mathematical Biology Tumor Growth
- Prostate Cancer Treatment and Research
- HER2/EGFR in Cancer Research
- Cardiac Imaging and Diagnostics
- Advanced Neuroimaging Techniques and Applications
- Traumatic Brain Injury and Neurovascular Disturbances
- Cancer Genomics and Diagnostics
- Epilepsy research and treatment
- Privacy-Preserving Technologies in Data
University of Washington
2016-2025
University of Washington Medical Center
2002-2024
University Radiology
2008-2023
University College Cork
2014-2022
Seattle Cancer Care Alliance
2007-2021
University of Pittsburgh
2017
University of Pennsylvania
2017
Fred Hutch Cancer Center
2011
Cancer Research Center
2011
Arizona Oncology
2011
Abstract Purpose: The aim of this study is to compare glucose metabolism and hypoxia in four different tumor types using positron emission tomography (PET). 18F-labeled fluorodeoxyglucose (FDG) evaluates energy metabolism, whereas the uptake fluoromisonidazole (FMISO) proportional tissue hypoxia. Although acute results accelerated glycolysis, cellular slowed chronic hypoxia, prompting us look for discordance between FMISO FDG uptake. Experimental Design: Forty-nine patients (26 with head...
Abstract Purpose: Hypoxia is associated with resistance to radiotherapy and chemotherapy activates transcription factors that support cell survival migration. We measured the volume of hypoxic tumor maximum level hypoxia in glioblastoma multiforme before [18F]fluoromisonidazole positron emission tomography assess their impact on time progression (TTP) or survival. Experimental Design: Twenty-two patients were studied biopsy between resection starting radiotherapy. Each had a 20-minute scan 2...
Glioblastoma multiforme (GBM) are aggressive and uniformly fatal primary brain tumors characterized by their diffuse invasion of the normal-appearing parenchyma peripheral to clinical imaging abnormality. Hypoxia, a hallmark tumor behavior often noted in GBMs, has been associated with resistance therapy, poorer survival, more malignant phenotypes. Based on existence set novel techniques modeling tools, our objective was assess hypothesized quantitative link between growth kinetics [assessed...
Pharmacokinetic analysis of dynamic contrast-enhanced magnetic resonance imaging (DCE-MRI) time-course data allows estimation quantitative parameters such as Ktrans (rate constant for plasma/interstitium contrast agent transfer), ve (extravascular extracellular volume fraction), and vp (plasma fraction). A plethora factors in DCE-MRI acquisition can affect accuracy precision these and, consequently, the utility assessing therapy response. In this multicenter challenge, acquired at one center...
Structural and functional alterations in tumor vasculature are thought to contribute hypoxia which is a primary driver of malignancy through its negative impact on the efficacy radiation, immune surveillance, apoptosis, genomic stability, accelerated angiogenesis. We performed prospective, multicenter study test hypothesis that abnormal hypoxia, as measured with MRI PET, will negatively survival patients newly diagnosed glioblastoma. Prior start chemoradiation, glioblastoma underwent scans...
This multicenter study evaluated the effect of variations in arterial input function (AIF) determination on pharmacokinetic (PK) analysis dynamic contrast-enhanced magnetic resonance imaging (DCE-MRI) data using shutter-speed model (SSM). Data acquired from eleven prostate cancer patients were shared among nine centers. Each center used a site-specific method to measure individual AIF each set and submitted results managing center. These AIFs, their reference tissue-adjusted variants,...
Glioblastoma multiforme is a primary brain tumor known for its rapid proliferation, diffuse invasion, and prominent neovasculature necrosis. This study explores the <i>in vivo</i> link between these characteristics hypoxia by comparing relative spatial geometry of developing vasculature inferred from gadolinium-enhanced T1-weighted MRI (T1Gd), edematous extent revealed on T2-weighted (T2), assessed <sup>18</sup>F-fluoromisonidazole PET (<sup>18</sup>F-FMISO). Given role in upregulating...
The multiple-drug resistance (MDR) transporter P-glycoprotein (P-gp) is highly expressed at the human blood–brain barrier (BBB). P-gp actively effluxes a wide variety of drugs from central nervous system, including anticancer drugs. We have previously demonstrated activity BBB using PET <sup>11</sup>C-verapamil distribution into brain in absence and presence inhibitor cyclosporine-A (CsA). Here we extend initial noncompartmental analysis these data apply compartmental modeling to verapamil...
Changes in tumor metabolism from positron emission tomography (PET) locally advanced breast cancer (LABC) patients treated with neoadjuvant chemotherapy (NC) are predictive of pathologic response. Serial dynamic [(18)F]-FDG (fluorodeoxyglucose) PET scans were used to compare kinetic parameters the standardized uptake value (SUV) as predictors response, disease-free survival (DFS), and overall (OS).Seventy-five LABC underwent FDG prior at midpoint NC. delivery (K(1)), flux (K(i)), SUV...
Our objective was to determine whether early change in standardized uptake values (SUVs) of 3′deoxy-3′-<sup>18</sup>F-fluorothymidine (<sup>18</sup>F-FLT) using PET with CT could predict pathologic complete response (pCR) primary breast cancer neoadjuvant chemotherapy (NAC). The key secondary correlate SUV the proliferation marker Ki-67 at baseline and after NAC. <b>Methods:</b> This prospective, multicenter phase II study did not specify therapeutic regimen, thus, NAC varied among centers....
This study tested the feasibility of C11-acetate (acetate) positron emission tomography (PET) imaging to assess response therapy in men with bone metastatic prostate cancer and compared results for disease detection evaluation F-18 fluorodeoxyglucose (FDG) PET.Men ≥3 metastases identified by Tc-99m methylene diphosphonate (MDP) scintigraphy and/or computed were enrolled a prospective serial acetate FDG PET imaging. Patients imaged before 6 12 weeks after initial androgen deprivation new or...
Pharmacokinetic analysis of dynamic contrast-enhanced (DCE) MRI data allows estimation quantitative imaging biomarkers such as Ktrans (rate constant for plasma/interstitium contrast reagent (CR) transfer) and ve (extravascular extracellular volume fraction). However, the use DCE-MRI in clinical practice is limited with uncertainty arterial input function (AIF) determination being one primary reasons. In this multicenter study to assess effects AIF variations on pharmacokinetic parameter...
Radiomic features are being increasingly studied for clinical applications. We aimed to assess the agreement among radiomic when computed by several groups using different software packages under very tightly controlled conditions, which included standardized feature definitions and common image data sets. Ten sites (9 from NCI's Quantitative Imaging Network] positron emission tomography–computed tomography working group plus one site outside that group) participated in this project. Nine...
Using positron emission tomography imaging, we determined the hepatic concentrations and hepatobiliary transport of [ 11 C]rosuvastatin (RSV; i.v. injection) in absence ( n = 6) presence 4 cyclosporin A (CsA; infusion) following a therapeutic dose unlabeled RSV (5 mg, p.o.) healthy human volunteers. The sinusoidal uptake, efflux, biliary efflux clearance (CL; mL/minute) C]RSV, estimated through compartment modeling were 1,205.6 ± 384.8, 16.2 11.2, 5.1 1.8, respectively 6). CsA (blood...