A5045056725- Glioma Diagnosis and Treatment
- Medical Imaging Techniques and Applications
- Cancer, Hypoxia, and Metabolism
- Radiomics and Machine Learning in Medical Imaging
- Advanced MRI Techniques and Applications
- Meningioma and schwannoma management
- MRI in cancer diagnosis
- Traumatic Brain Injury and Neurovascular Disturbances
- Head and Neck Surgical Oncology
- Brain Metastases and Treatment
- Management of metastatic bone disease
- Facial Trauma and Fracture Management
- Acute Ischemic Stroke Management
- Neurofibromatosis and Schwannoma Cases
- Teratomas and Epidermoid Cysts
- Spinal Fractures and Fixation Techniques
- Cerebrospinal fluid and hydrocephalus
- Traumatic Ocular and Foreign Body Injuries
- Effects of Radiation Exposure
- Otitis Media and Relapsing Polychondritis
- Chromatin Remodeling and Cancer
- Pituitary Gland Disorders and Treatments
- Ocular Oncology and Treatments
- Trigeminal Neuralgia and Treatments
- Trauma Management and Diagnosis
University of Washington
2011-2021
University of Washington Medical Center
2008-2019
Neurological Surgery
2013
University College Cork
2013
Harborview Medical Center
2008
University of California, Los Angeles
2000-2005
New York Medical College
1998
Structural and functional alterations in tumor vasculature are thought to contribute hypoxia which is a primary driver of malignancy through its negative impact on the efficacy radiation, immune surveillance, apoptosis, genomic stability, accelerated angiogenesis. We performed prospective, multicenter study test hypothesis that abnormal hypoxia, as measured with MRI PET, will negatively survival patients newly diagnosed glioblastoma. Prior start chemoradiation, glioblastoma underwent scans...
To compare 3 Tesla (3T) multi-voxel and single-voxel proton MR spectroscopy (MRS), dynamic susceptibility contrast perfusion MRI (DSC), diffusion-weighted (DWI) for distinguishing recurrent glioma from postradiation injury.We reviewed all 3T MRS, DSC DWI studies performed suspicion of malignant recurrence between October 2006 December 2008. Maximum Cho/NAA Cho/Cr peak-area peak-height ratios were recorded both MRS. cerebral blood volume (CBV) minimum apparent diffusion coefficient (ADC)...
(18)F-fluoromisonidazole ((18)F-FMISO) is the most widely used PET agent for imaging hypoxia, a condition associated with resistance to tumor therapy. (18)F-FMISO equilibrates in normoxic tissues but retained under hypoxic conditions because of reduction and binding macromolecules. A simple tissue-to-blood (TB) ratio suitable quantifying hypoxia. TB threshold 1.2 or greater useful discriminating volume (HV) tissue; TBmax maximum intensity region does not invoke threshold. Because elimination...
The advancement of multidetector CT technology has resulted in improved image quality as well an increase ionizing radiation dose to patient. purpose this study was assess and overall examination the neck between fixed-tube current automatic tube modulation (ATCM) at 2 separate noise index levels.A total 84 patients underwent with use a 64-section row (MDCT) scanner. Patients were divided into 3 groups: (n = 28), ATCM 11.4 20.2 28). All other scan parameters remained constant. Scan coverage...
Over 65,000 primary brain tumors are diagnosed annually in the US alone. Malignant gliomas represent more than one-third of such cases. Despite advances neuroimaging, surgical techniques, radiotherapy and chemotherapy, survival rate this disease remains poor. The introduction agents which disrupt function vascular endothelial growth factor (VEGF) its receptors to glioma therapy has resulted an unusually high percentage patients experiencing radiographic responses. Bevacizumab, approved by...
A multi-center imaging trial by the American College of Radiology Imaging Network (ACRIN) "A Multicenter, phase II assessment tumor hypoxia in glioblastoma using 18F Fluoromisonidazole (FMISO) with PET and MRI (ACRIN 6684)", was conducted to assess patients (GBM). The aims this study were support role proton magnetic resonance spectroscopic (1H MRSI) as a prognostic marker for brain clinical trials. Seventeen participants from four sites had analyzable 3D MRSI datasets acquired on Philips,...
Hypoxia is associated with resistance to radiotherapy and chemotherapy in malignant gliomas, it can be imaged by positron emission tomography 18F-fluoromisonidazole (18F-FMISO). Previous results for patients brain cancer 18F-FMISO at a single center before conventional chemoradiotherapy showed that tumor uptake via T/Bmax (tissue SUVmax/blood SUV) hypoxic volume (HV) was poor survival. However, multicenter clinical trial (ACRIN 6684), traditional parameters were not found prognostically...
<h3>BACKGROUND AND PURPOSE:</h3> Effective management of patients with brain tumors depends on accurate detection and characterization lesions. This study aimed to demonstrate the noninferiority gadoterate meglumine versus gadobutrol for overall visualization primary tumors. <h3>MATERIALS METHODS:</h3> multicenter, double-blind, randomized, controlled intraindividual, crossover, included 279 patients. Both contrast agents (dose = 0.1 mmol/kg body weight) were assessed 2 identical MRIs at a...