About
Contact & Profiles
A5063733373
Research Areas
- Bladder and Urothelial Cancer Treatments
- Epigenetics and DNA Methylation
- Cancer Immunotherapy and Biomarkers
Northwestern University
2022
The long-term survival of patients with advanced urothelial carcinoma (UCa) is limited because innate resistance to treatment. We identified elevated expression the histone methyltransferase EZH2 as a hallmark aggressive UCa and hypothesized that inhibition, via small-molecule catalytic inhibitor, might have antitumor effects in UCa. Here, carcinogen-induced mouse bladder cancer model, reduction tumor progression an increase immune infiltration upon inhibition were observed. Treatment mice...
10.1126/sciadv.abo8043
article
EN
cc-by-nc
Science Advances
2022-10-05
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