A5072847974- Sexual function and dysfunction studies
- Hormonal and reproductive studies
- Sexuality, Behavior, and Technology
- Sperm and Testicular Function
- Genital Health and Disease
- Chromosomal and Genetic Variations
- Plant Genetic and Mutation Studies
- Urinary Bladder and Prostate Research
- Sexual Differentiation and Disorders
- Urological Disorders and Treatments
- Wheat and Barley Genetics and Pathology
- Hypothalamic control of reproductive hormones
- Healthcare and Venom Research
- Traditional Chinese Medicine Studies
- Plant Molecular Biology Research
- Genetic and Clinical Aspects of Sex Determination and Chromosomal Abnormalities
- Reproductive tract infections research
- Eating Disorders and Behaviors
- Marine and coastal ecosystems
- Renal and related cancers
- MicroRNA in disease regulation
- Sleep and Wakefulness Research
- Urologic and reproductive health conditions
- Plant Gene Expression Analysis
- Ureteral procedures and complications
First Affiliated Hospital of Anhui Medical University
2016-2025
Anhui Medical University
2016-2025
Zaozhuang University
2025
Shanghai Institute of Materia Medica
2025
Chinese Academy of Sciences
2025
Ocean University of China
2021-2024
Guilin Medical University
2022-2023
Shandong Agricultural University
2005-2023
Anhui Provincial Children's Hospital
2022
Chinese Academy of Fishery Sciences
2020-2022
ABSTRACT Low environmental temperatures promote anthocyanin accumulation and fruit colouration by up‐regulating the expression of genes involved in biosynthesis regulation many trees. However, molecular mechanism which trees regulate this process response to low temperature (LT) remains largely unknown. In study, cold‐induced bHLH transcription factor gene MdbHLH3 was isolated from an apple tree found interact physically specifically through two regions (amino acids 1–23 186–228) at N...
Abstract Background MicroRNAs (miRNAs), a class of small non-coding RNA molecules, are indicated to play essential roles in spermatogenesis. However, little is known about the expression patterns or function miRNAs human testes involved infertility. Methods In this study, miRNA profiles patients with non-obstructive azoospermia (NOA) and normal controls were performed by using microarray technologies. Results Altered microRNA NOA was found, 154 differentially down-regulated 19 up-regulated...
Abstract Background Chromosomal instability (CIN), a hallmark of cancer, is commonly linked to poor prognosis in high‐grade prostate cancer (PCa). Paradoxically, excessively high levels CIN may impair cell viability. Consequently, understanding how tumours adapt critical for identifying novel therapeutic targets. Methods Bioinformatic analyses were conducted identify genes overexpressed PCa tissues using The Cancer Genome Atlas (TCGA) and GEO datasets. Western blotting immunohistochemistry...
Abnormal body mass index (BMI) is associated with an increased risk of erectile dysfunction (ED). However, the relationship between different BMI categories and levels ED severity remains unclear. In current study, 878 men from andrology clinic in Central China were recruited. Erectile function was assessed by International Index Function (IIEF) scores. Questionnaires included questions about demographic characteristics (age, height, weight, educational status), lifestyle habits (drinking,...
Non-obstructive azoospermia (NOA) is the most severe type of male infertility, affecting 1% men worldwide. Most its etiologies remain idiopathic. Although genetic studies have identified dozens NOA genes, monogenic mutations can also account for a small proportion idiopathic cases. Hence, this study was conducted to explore causes variants in cohort Chinese patients.Following screening using chromosomal karyotyping, Y chromosome microdeletion analyses, and sex hormone assessments, subsequent...
Premature ejaculation (PE) is the most prevalent sexual dysfunction among men. Eejaculation involves a complex nervous mechanism in which ejaculatory centers play key role modulating sperm emission. Although treatment possibilities span from psychotherapy to pharmacological approaches, results show inconsistent efficacy. In this context, emergence of repetitive transcranial magnetic stimulation (rTMS) as non-invasive neuromodulatory approach represents compelling avenue for potential...
Abstract Background Erectile dysfunction (ED) is a common condition affecting millions of men worldwide. While genome‐wide association studies (GWAS) have identified genetic loci associated with ED risk, the potential causative genes and their biological mechanisms leading to remain largely unexplored. Objectives This study aimed conduct comprehensive cross‐tissue transcriptome‐wide (TWAS) identify susceptibility risk. Materials methods We conducted TWAS analysis integrating GWAS data for...
Pollen hydration is a critical step that determines pollen germination on the stigma. KINβγ plant-specific subunit of SNF1-related protein kinase 1 complex (SnRK1 complex). In Arabidopsis kinβγ mutant, levels reactive oxygen species were decreased which lead to compromised mutant this study, we analyzed gene expression in by RNA-seq and found inward shaker K+ channel SPIK was down-regulated pollen. Furthermore, showed spik defective wild-type stigma, although demonstrated normal vitro....
Abstract Background: To date, no study has evaluated trends in the burden of alcohol-induced cirrhosis and other chronic liver diseases based on Global Burden Diseases, Injuries, Risk Factors (GBD) 2019 study. Herein, we report global terms age, sex, sociodemographic index (SDI) from 1990 to 2019, analysis GBD data. Methods: The estimated annual percentage change (EAPC) was calculated determine age-standardized incidence mortality rates disability-adjusted life years (DALYs) for diseases....
Abstract Several different mutations in the proteome of centriole 1 centriolar protein B (POC1B) have been linked to cone dystrophy or cone-rod (CORD). However, POC1B that are associated with both CORD and oligoasthenoteratozoospermia (OAT) not reported previously. Here, whole-exome sequencing was performed identify a homozygous frameshift variant (c.151delG) two brothers who had diagnosed OAT from consanguineous family. Transcript analyses biological samples patients carrying showed is lost...
Penile cancer (PeCa) is a relatively rare tumor entity but possesses higher morbidity and mortality rates especially in developing countries. To date, the concrete pathogenic signaling pathways core machineries involved tumorigenesis progression of PeCa remain to be elucidated. Several studies suggested miRNAs, which modulate gene expression at posttranscriptional level, were frequently mis-regulated aberrantly expressed human cancers. However, miRNA profile has not been reported before. In...
BACKGROUND:MicroRNAs (miRNAs) play pivotal roles in spermatogenesis. MicroRNA-210 (miR-210) expression was up-regulated the testes of sterile men with non-obstructive azoospermia (NOA). However, underlying mechanisms miR-210 involved spermatogenesis patients NOA are unknown.MATERIAL AND METHODS:Expression and insulin-like growth factor II (IGF2) cases (only including maturation arrest hypospermatogenesis) were detected this study. We carried out vitro experiments to determine if IGF2...
Although translational research into autosomal dominant polycystic kidney disease (ADPKD) and its pathogenesis has made considerable progress, there is presently lack of standardized animal model for preclinical trials. In this study, we developed an orthologous mouse human ADPKD by cross-mating Pkd2 conditional-knockout mice (Pkd2f3 ) to Cre transgenic in which driven a spectrum kidney-related promoters. By systematically characterizing the model, found that Pkd2f3/f3 with transgene...
Autosomal dominant polycystic kidney disease (ADPKD) can be caused by mutations in the PKD1 or PKD2 genes. The gene product is a Wnt cell-surface receptor. We previously showed that lack of product, PC2, increases β-catenin signaling mouse embryonic fibroblasts, renal epithelia, and isolated collecting duct cells. However, it remains unclear whether plays role phenotypes if inhibitor halt cyst formation ADPKD models. Here, using genetic pharmacologic approaches, we demonstrated elevated PC2...
Abstract Introduction In 2014, new evidence-based definitions of lifelong premature ejaculation (LPE) and acquired (APE) were proposed by the International Society for Sexual Medicine. Based on PE definitions, prevalence factors associated with LPE APE have not been investigated in China. Aim To evaluate men complaint Methods From December 2011 to 2015, a cross-sectional field survey was conducted five cities Anhui province Questionnaire data 3,579 collected our database. The questionnaire...
Abstract Cumulative evidence suggests that abnormal differentiation of T lymphocytes influences the pathogenesis chronic prostatitis/chronic pelvic pain syndrome (CP/CPPS). Thus, understanding immune activation landscape CP/CPPS would be helpful for improving therapeutic strategies. Here, we utilized BD™ AbSeq to digitally quantify both protein and mRNA expression levels in single peripheral blood cells from two patients healthy controls. We an integrated strategy based on canonical...