A5100425738- Urinary Bladder and Prostate Research
- Autophagy in Disease and Therapy
- MicroRNA in disease regulation
- Kruppel-like factors research
- Cancer-related molecular mechanisms research
- Cancer-related gene regulation
- Prostate Cancer Diagnosis and Treatment
- Prostate Cancer Treatment and Research
- Circular RNAs in diseases
- Circadian rhythm and melatonin
- RNA modifications and cancer
- Pelvic floor disorders treatments
- Renal cell carcinoma treatment
- Immunotherapy and Immune Responses
- Hormonal and reproductive studies
- Ferroptosis and cancer prognosis
- Immune Cell Function and Interaction
- Epigenetics and DNA Methylation
- Cancer Immunotherapy and Biomarkers
- Renal and related cancers
- Cytokine Signaling Pathways and Interactions
- Plant Toxicity and Pharmacological Properties
- Cancer, Lipids, and Metabolism
- CAR-T cell therapy research
- Dermatology and Skin Diseases
First Affiliated Hospital of Anhui Medical University
2016-2025
Anhui Medical University
2016-2025
Fujian Medical University
2021-2025
Henan Agricultural University
2025
Fujian Provincial Hospital
2025
Wuhan University of Science and Technology
2023-2025
University of Electronic Science and Technology of China
2023-2025
Second Xiangya Hospital of Central South University
2023-2025
Central South University
2023-2025
Nanjing University of Chinese Medicine
2022-2025
Biochemical basis of a 24-hour clock Circadian clocks keep organisms in synch with such daily cycles as illumination, activity, and food availability. The circadian cyanobacteria has the necessary period despite its three component proteins having biochemical activities that occur on much faster time scale. Abe et al. focused cyanobacterial KaiC, an adenosine triphosphatase (ATPase) can autophosphorylate autodephosphorylate. slow ATPase activity which is linked to peptide isomerisation,...
Abstract Commensal bacteria generate immensely diverse active metabolites to maintain gut homeostasis, however their fundamental role in establishing an immunotolerogenic microenvironment the intestinal tract remains obscure. Here, we demonstrate that understudied murine commensal bacterium, Dubosiella newyorkensis , and its human homologue Clostridium innocuum have a probiotic immunomodulatory effect on dextran sulfate sodium-induced colitis using conventional, antibiotic-treated germ-free...
Atopic dermatitis (AD) is an inflammatory skin disease characterized by chronic recurrent with profound itching. Most patients have personal and/or family history of atopic diseases. Several criteria been proposed for the diagnosis AD. Although clinical features childhood AD widely studied, there has less large-scale study on adult/adolescent The aim this was to investigate symmetrical eczema/AD and propose Chinese diagnostic AD.A hospital-based performed. Forty-two dermatological centers...
Enhancing tumor chemotherapy and overcoming drug resistance through autophagy-mediated intracellular dissolution of zinc oxide nanoparticles.
Abstract Brain insulin resistance, induced by neuroinflammation and oxidative stress, contributes to neurodegeneration, that is, processes are associated with Aβ accumulation TAU hyperphosphorylation. Here, we tested the effect of chronic administration melatonin (MLT) on brain resistance cognition deficits caused a high‐fat diet (HFD) in aged rats. Results showed MLT supplementation attenuated peripheral lowered hippocampal stress levels. Activated microglia astrocytes levels TNF‐α HFD‐fed...
Chronic prostatitis/chronic pelvic pain syndrome (CP/CPPS) is a very common urological disorder and has been gradually regarded as an immune-mediated disease. Multiple studies have indicated that the gut microflora plays pivotal part in immune homeostasis autoimmune development. However, whether affects CP/CPPS, underlying mechanism behind them remain unclear. Here, we built experimental prostatitis (EAP) mouse model by subcutaneous immunity identified its Th17/Treg frequency was imbalanced....
Abstract Iron oxide nanoparticles (IONPs)-based contrast agents are widely used for T 2 -weighted magnetic resonance imaging (MRI) in clinical diagnosis, highlighting the necessity and importance to evaluate their potential systematic toxicities. Although a few previous studies have documented toxicity concerns of IONPs major organs, limited data available on reproductive caused by IONPs, especially when administrated via intravenous injection mimic use MRI agents. Our study aimed determine...
Abstract Emerging evidence has highlighted that dysregulation of lipid metabolism in clear cell renal carcinoma (ccRCC) is associated with tumor development and progression. HIF-2α plays an oncogenic role ccRCC involved abnormal accumulation. However, the underlying mechanisms between these two phenomena remain unknown. Here, MED15 was demonstrated to be a dominant factor for HIF-2α-dependent accumulation promoted transcriptional activation by directly binding promoter region, overexpression...
Autophagy, an evolutionarily conserved response to stress, has recently been implicated in cancer initiation and progression, but the detailed mechanisms functions have not yet fully elucidated. One major obstacle our understanding is lack of efficient robust method specifically monitor autophagic cells specimens. To identify molecular events associated with autophagy, we performed cDNA microarray analysis glioblastoma cell lines. Based on analysis, raised a polyclonal antibody against...
Study Type – Therapy (RCT) Level of Evidence 1b OBJECTIVE To present 2‐year follow‐up data a randomized clinical trial comparing bipolar transurethral resection in saline (TURIS) with monopolar the prostate (TURP). PATIENTS AND METHODS In all, 100 consecutive patients benign prostatic hyperplasia (BPH) were to TURIS or TURP. The breath ethanol test was used before and every 10 min during surgery assess fluid absorption. Complications treatment efficacy evaluated after surgery. RESULTS...
Ischemia-reperfusion (I/R) injury induces the generation of reactive oxygen species (ROS), which results in a poor prognosis for ischemic stroke patients. This study was designed to evaluate time course expression Nox family, major source ROS, and whether melatonin, potent scavenger influences these parameters rat model cerebral I/R caused by middle artery occlusion (MCAO). After 2-hr occlusion, filament withdrawn allow reperfusion. At 0, 3, 6, 12, 24, 48 hr after reperfusion, brain tissue...
MK-8776 is a recently described inhibitor that highly selective for checkpoint kinase 1 (Chk1), which can weaken the DNA repair capacity in cancer cells to achieve chemo-sensitization. A number of studies show enhances cytotoxicity hydroxyurea and gemcitabine without increasing normal tissue toxicities. Thus far, there no evidence be used as radiotherapy sensitization agent. In this study, we investigated effects on radiosensitivity 3 human triple-negative breast (TNBC) cell lines...
The heterogeneity of the immune microenvironment leads to different responses in checkpoint blockade therapy. We aimed propose a robust molecular classification system investigate relevance subtype and prognosis prostate cancer patients, as well therapeutic response A total 1,557 patients were enrolled, including 69 real‐world samples from our institute (titled AHMU‐PC cohort). non‐negative matrix factorization algorithm was employed virtually microdissect patients. enrichment characterized...
Chronic prostatitis and chronic pelvic pain syndrome (CP/CPPS) is an inflammatory immune disease characterized by intraprostatic leukocyte infiltration or perineal pain. Macrophages play vital roles in the pathogenesis of CP/CPPS. However, mechanisms controlling activation chemotaxis macrophages CP/CPPS remain unclear. This study aimed to investigate CXCL10/CXCR3 pathway patients. The serums patients healthy volunteers were collected measured. Results showed that CXCL10 expression was...
Abstract Therapeutic efficacy for prostate cancer is highly restricted by insufficient drug accumulation and the resistance to apoptosis immunogenic cell death (ICD). Although enhanced permeability retention (EPR) effect of magnetic nanomaterials could benefit from external field, it falls off rapidly with increased distance magnet surface. Considering deep location in pelvis, improvement EPR field limited. In addition, cGAS‐STING pathway inhibition‐related immunotherapy are major obstacles...
Abstract This study aims to verify whether the inhibitory effect of Sirtuin 3 (SIRT3) on formation renal calcium oxalate crystals was mediated through promoting macrophages (Mϕs) polarization. Identification and quantification M1 M2 monocytes were performed using fluorescence‐activated cell sorting analysis. SIRT3 protein level forkhead box O1 (FOXO1) acetylation measured western blot Cell apoptosis HK‐2 detected by flow cytometry. Mouse kidney tissues subjected Von Kossa staining, terminal...
The dismal prognosis of patients with glioma is largely attributed to cancer stem cells that display pivotal roles in tumour initiation, progression, metastasis, resistance therapy, and relapse. Therefore, understanding how these populations maintain their stem-like properties critical developing effective therapeutics.RNA sequencing analysis was used identify genes potentially involved regulating (GSCs). Integrin β4 (ITGB4) expression validated by quantitative real-time PCR (qRT-PCR)...
Chronic prostatitis/chronic pelvic pain syndrome (CP/CPPS) is a prevalent disease of the urogenital system. Alcohol has been reported to be closely related CP/CPPS. Thus, we intended verify role alcohol in CP/CPPS and determine underlying mechanism.We induced experimental autoimmune prostatitis (EAP) mouse model by intradermally injecting mixture prostate antigens (PAgs) complete Freund's adjuvant on days 0 28. Mice were treated with (control-alcohol EAP-alcohol groups) or vehicle...