A5101606520- Nanoplatforms for cancer theranostics
- Polysaccharides and Plant Cell Walls
- Advanced Nanomaterials in Catalysis
- Antimicrobial Peptides and Activities
- Aquaculture disease management and microbiota
- Nanoparticle-Based Drug Delivery
- Ginseng Biological Effects and Applications
- Immune Response and Inflammation
- Polysaccharides Composition and Applications
- Extracellular vesicles in disease
- Gut microbiota and health
- Drilling and Well Engineering
- Molecular Sensors and Ion Detection
- Concrete and Cement Materials Research
- Hydraulic Fracturing and Reservoir Analysis
- Phytochemical compounds biological activities
- Remote Sensing in Agriculture
- Seaweed-derived Bioactive Compounds
- CRISPR and Genetic Engineering
- Fungal Biology and Applications
- Photodynamic Therapy Research Studies
- Metal-Organic Frameworks: Synthesis and Applications
- Cholangiocarcinoma and Gallbladder Cancer Studies
- Dam Engineering and Safety
- Cancer Mechanisms and Therapy
Changchun University of Chinese Medicine
2023-2024
Zhejiang University
2023-2024
Jilin Medical University
2020-2024
Yangtze University
2023-2024
University of Science and Technology of China
2023
China University of Petroleum, East China
2022-2023
Dalian Minzu University
2022-2023
Anhui Medical University
2019-2022
First Affiliated Hospital of Anhui Medical University
2019-2022
Anhui Provincial Hospital
2022
Nanozymes that mimic peroxidase (POD) activity can convert H2O2 into bactericidal free radicals, which is referred to as chemodynamic therapy (CDT). High glutathione (GSH) levels in the infectious tissue severely limit performance of CDT. Herein, we report a near-infrared-controlled antibacterial nanoplatform based on encapsulating tungsten sulfide quantum dots (WS2QDs) and antibiotic vancomycin thermal-sensitive liposome. The system exploits photothermal sensitivity WS2QDs achieve selective...
Enhancing tumor chemotherapy and overcoming drug resistance through autophagy-mediated intracellular dissolution of zinc oxide nanoparticles.
Vasculogenic mimicry (VM) with the pattern of endothelial independent tubular structure formation lined by aggressive tumor cells mimics regular blood vessels to ensure robust supply and correlates proliferation, invasion, metastasis, poor prognosis malignant tumors, which was demonstrated be a major obstacle for resistance antiangiogenesis therapy. Therefore, it is urgent discover methods abrogate VM possesses important practical significance improving Brucine traditional medicinal herb...
These observations highlight that SCFAs promote macrophage elimination of K. pneumoniae via a LAMTOR2-dependent signal pathway and suggest it is possible to intervene in pneumonia by targeting the gut microbiota.
Tumor microenvironment (TME)-responsive chemodynamic therapy (CDT) mediated by nanozymes has been extensively studied in oral squamous cell carcinoma. However, the low catalytic efficiency due to insufficient H2O2 TME is still a major challenge for its clinical translation. Herein, we present an antitumor nanoplatform based on Mn–Co organometallic framework material (MnCoMOF), which shows peroxidase-like (POD-like) activity, loaded with glucose oxidase (GOx@MnCoMOF), demonstrating ability of...
C. A. Meyer is a dual-purpose plant for medicine and food, its polysaccharide considered as an immune enhancer. Four polysaccharides, WGP-20-F, WGP-40-F, WGP-60-F WGP-80-F were obtained from ginseng via water extraction gradient ethanol precipitation with different molecular weights (
Magnesium oxychloride cement (MOC) possesses some excellent characteristics, which can be used as oil well cement, to deal with the complex environmental conditions in and gas wells. However, water resistance property of MOC is poor. In this study, a new type magnesium improved was developed by modifying pore structure pure using hydrophobic admixtures. To assess performance MOC, range tests were performed, including compressive strength, softening coefficient, capillary absorption, size...
Given the increasing prevalence of Staphylococcus aureus antibiotic resistance, there is an urgent need to repurpose approved drugs with known pharmacology and toxicology as alternative therapeutic strategy. We have reported that sustained monotherapy auranofin (AUR) inevitably resulted in reduced susceptibility or even emergence resistance AUR S. aureus. However, whether drug combination could increase antibacterial activity while preventing still unknown. Here, we focused on important role...
Klebsiella pneumoniae-induced liver abscess (KLA) is a type of pyogenic (PLA), which distinct invasive syndrome that has been increasingly reported worldwide over the past two decades. The intestinal microbiota recognized as an important modulator can promote and maintain host immune homeostasis. However, its precise role in unknown. We aimed to investigate function gut defense against K. pneumoniae infection.We constructed C57BL/6J mice with KLA analyzed diversity richness microflora by 16S...
The high mortality associated with drug-resistant bacterial infections is an intractable clinical problem resulting from the low susceptibility of these bacteria to antibiotics and incidence recurrent infections. Herein, a photosynthetic bacteria-based multiplex system (Rp@Al) composed natural Rhodopseudomonas palustris (Rp) Food Drug Administration-approved aluminum (Al) adjuvant, was developed combat prevent their recurrence. We examined its photothermal performance in vitro vivo...
Due to the existence of grass carp reovirus (GCRV), hemorrhagic disease occurs frequently, and its high pathogenicity infectivity are great challenges aquaculture industry. As a highly pathogenic pathogen, outbreak often causes tremendous economic losses. Therefore, it is important rapidly accurately detect GCRV on site control timely.In this study, recombinant enzyme amplification (RPA) combined with clustered regularly interspaced short palindromic repeats (CRISPR)/Cas13a system was...
Macrophages are important inflammatory cells that play a vital role in inflamm‐aging. Bupleurum chinense polysaccharide (BCP), an effective component of the herb, exerts multiple beneficial pharmacological effects, such as improving immunity and antioxidant activity. However, effects BCP on macrophage‐aging inflamm‐aging yet to be established. In this study, we examined proliferation, cytokines, β ‐galactosidase (SA‐ ‐gal), senescence‐associated heterochromatin foci (SAHF), reactive oxygen...
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