A5034939465- Peptidase Inhibition and Analysis
- Neuropeptides and Animal Physiology
- RNA modifications and cancer
- Microtubule and mitosis dynamics
- Cancer-related gene regulation
- Cancer, Lipids, and Metabolism
- Signaling Pathways in Disease
- Chemical Synthesis and Analysis
- Lung Cancer Treatments and Mutations
- Liver physiology and pathology
- Liver Disease Diagnosis and Treatment
- Cancer-related Molecular Pathways
- Machine Learning in Bioinformatics
- Angiogenesis and VEGF in Cancer
- Plant-based Medicinal Research
- Epigenetics and DNA Methylation
- Bioinformatics and Genomic Networks
- Lung Cancer Diagnosis and Treatment
- Gene expression and cancer classification
- Fibroblast Growth Factor Research
- Gastric Cancer Management and Outcomes
- Lymphoma Diagnosis and Treatment
- Bone and Dental Protein Studies
- Heat shock proteins research
- Endoplasmic Reticulum Stress and Disease
National Central University
2014-2025
Lanzhou University
2025
Shanghai Customs College
2024
Xuan Wu Hospital of the Capital Medical University
2010-2024
Sichuan Provincial Hospital of Traditional Chinese Medicine
2024
The Central Hospital of Xiao gan
2024
National Cheng Kung University
2022
Anhui Medical University
2014-2020
First Affiliated Hospital of Anhui Medical University
2019-2020
Institute of Biomedical Science
2019
Abstract Background The development of microarrays permits us to monitor transcriptomes on a genome-wide scale. To validate microarray measurements, quantitative-real time-reverse transcription PCR (Q-RT-PCR) is one the most robust and commonly used approaches. new challenge in gene quantification analysis how explicitly incorporate statistical estimation such studies. In realm analysis, various available methods probe level normalization for may result distinctly different target selections...
Increasing evidence suggests that PRMT 5, a protein arginine methyltransferase, is involved in tumorigenesis. However, no systematic research has demonstrated the cell‐transforming activity of 5. We investigated involvement 5 tumor formation. First, we showed was associated with many human cancers, through statistical analysis microarray data NCBI GEO database. Overexpression ectopic per se or its specific sh RNA enhanced reduced cell growth under conditions normal low concentrations serum,...
Lung adenocarcinoma is the leading cause of cancer-related deaths among both men and women in world. Despite recent advances diagnosis treatment, mortality rates with an overall 5-year survival only 15%. This high probably attributable to early metastasis. Although several well-known markers correlated poor/metastasis prognosis lung patients by immunohistochemistry was reported, molecular mechanisms development are still not clear. To explore novel their signaling pathways will be crucial...
Vasculogenic mimicry (VM) with the pattern of endothelial independent tubular structure formation lined by aggressive tumor cells mimics regular blood vessels to ensure robust supply and correlates proliferation, invasion, metastasis, poor prognosis malignant tumors, which was demonstrated be a major obstacle for resistance antiangiogenesis therapy. Therefore, it is urgent discover methods abrogate VM possesses important practical significance improving Brucine traditional medicinal herb...
Abstract Nasopharyngeal carcinoma (NPC) is known for its highly metastatic character. Recent advances in diagnosis and treatment have not improved the high mortality rate that attributable to early metastasis. Although several biomarkers correlate with metastasis prognosis, molecular mechanisms of NPC development progression remain unclear. We demonstrate comprehensively fibulin‐3 down‐regulated NPC. Loss expression significantly correlated advanced tumour lymph node‐metastasis stages,...
Dapper homolog (DACT) 2 is one of the Dact gene family members, which are important modulators Wnt signaling pathway. We aim to clarify its epigenetic inactivation, biological function and clinical implication in colon cancer. DACT2 was silenced five out eight cancer cell lines, but robustly expressed normal tissues. The loss expression regulated by promoter hypermethylation. Restoring lines suppressed tumor growth inducing apoptosis inhibiting proliferation both vitro vivo. Moreover,...
Vascular endothelial growth factor (VEGF) promotes angiogenesis and vascular permeability. The VEGF gene is polymorphic. We investigated the prognostic significance of three single nucleotide polymorphisms (SNP) in esophageal cancer.Three hundred sixty-one patients were genotyped for SNPs (-460T/C, 405G/C, 936C/T) using DNA extracted from prospectively collected blood samples. association each individual SNP, haplotypes SNPs, on overall survival (OS) was investigated.The variant allele...
Abnormal DRP1 expression has been identified in a variety of human cancers. However, the prognostic potential and mechanistic role head neck cancer (HNC) are currently poorly understood. Here, we demonstrated significant upregulation HNC tissues, that correlates with poor survival patients. Diminished suppressed tumor growth metastasis both vitro vivo models. was positively correlated FOXM1 MMP12 patient samples, suggesting pathological relevance context development. Moreover, depletion...
Dietary protein supplementation and physical activity are crucial for bone mineralization growth in early life.
Abstract Background The significant advances in microarray and proteomics analyses have resulted an exponential increase potential new targets promised to shed light on the identification of disease markers cellular pathways. We aim collect decipher HCC-related genes at systems level. Results Here, we build integrative platform, E ncyclopedia H epatocellular C arcinoma O nline, dubbed EHCO http://ehco.iis.sinica.edu.tw , systematically collect, organize compare pileup unsorted studies by...
The matrix metalloproteinase (MMP) family degrade extracellular and mediate pathways including apoptosis, angiogenesis immunity. We studied the association between four MMP polymorphisms within three genes esophageal adenocarcinoma (EA) risk prognosis. A total of 313 EA cases 455 age gender frequency-matched controls were genotyped for MMP1 1G/2G , MMP3 6A/5A MMP12 − 82A/G 1082A/G . individual was evaluated using regression models adjusted age, gender, adult body mass index smoking status....
BackgroundNasopharyngeal carcinoma (NPC) is known for its high metastatic potential and locoregional recurrence, although the molecular alterations that are driving NPC metastasis remain unclear at this time. This study aimed to examine expression of fibulin-5 in NPC, correlate results with clinicopathological variables survival, investigate role human cell lines. Material MethodsStandard semi-quantitative-RT-PCR, quantitative-RT-PCR, immunoblotting, immunohistochemistry were used mRNA...
Previous studies have identified a mixed‐phenotype of non‐small cell lung cancer (NSCLC) with co‐existing chronic obstructive pulmonary disease (COPD). Although NSCLC and COPD share common risk factor in smoking, whether how smoking may contribute to the coexistence (NSCLC‐COPD) is unclear. Our study suggests that cigarette major for development NSCLC‐COPD, especially females among patients squamous carcinoma subtype.
Uremic pruritus with elevated levels of calcium phosphate (CaP) in skin is a common symptom patients chronic kidney disease (CKD). In this study, we demonstrate that intradermal injection CaP into mice triggered scratching by up‐regulating the IL‐6 and phosphorylation ERKs dorsal root ganglion (DRG) dose‐dependent manner. essential because CaP‐induced up‐regulation phosphorylated (p)‐ERK DRG was considerably reduced knockout mice. Microarray analysis conjunction real‐time PCR revealed higher...
Cancer metastasis is a major barrier to its treatment and an important cause of patient death. Antimetastatic agents hold promise for patients with advanced metastatic tumors. Aminopeptidase N/CD13 (APN) being pursued by many as target against cancer angiogenesis, but there are few reports on the in vivo evaluation synthetic APN inhibitors. Herein, series compounds targeting were synthesized evaluated their antimetastasis antiangiogenesis potency both vitro vivo. Excitingly, 4m, 4t, 4cc,...
Hormone antagonist therapy for estrogen receptor positive (ER+) breast cancer patients post radical surgery and radiation has a poor prognosis also causes bone loss. 1 α ,25-dihydroxyvitamin D 3 [1 ,25(OH) 2 ] is potent antitumor agent in pre-clinical studies, but caused hypercalcemia when its effective doses were used. Therefore, we investigated the effects of less-calcemic analog, 19-nor-2 -(3-hydroxypropyl)-1 (MART-10), on ER+MCF-7 cells. We demonstrate that MART-10 500- to 1000-fold more...
The fact that many chemotherapeutic drugs cause chemoresistance and side effects during the course of colorectal cancer treatment necessitates development novel cytotoxic agents aiming to attenuate new molecular targets. Here, we show Astragalus membranaceus (Fischer) Bge. var. mongolicus (Bge.) Hsiao (AM), a traditional Chinese medicine, can inhibit tumor growth in vivo elucidate underlying mechanisms. antitumor effect AM was assessed on subcutaneous tumors human cell line HCT116 grafted...
Nonalcoholic fatty liver disease (NAFLD) is the most common and important chronic all over world. In present study, we found that koumine, main active ingredient isolated from Gelsemium elegans, has potential therapeutic effect on NAFLD rats by immunomodulatory activity. Koumine could significantly reduce level of TG, TC, LDL-C, ALT, AST in serum increase HDL-C, index, improve adipose-like lesions cells rats. Furthermore, treatment with koumine inhibited severity NAFLD. addition,...
The evolutionarily conserved Aurora family kinases, a of mitotic serine/threonine has three members in humans (Aurora-A, -B and -C). Overexpression members, particularly Aurora-A, been reported many human cancers cell lines. In this study, we present evidence based on comparative gene expression analysis via quantitative RT-PCR to delineate the relative contributions these kinases 60 lines statistical five different cancer microarray datasets. demonstrated selective upregulation various...
Nasopharyngeal carcinoma (NPC) is well-known for its highly metastatic characteristics, but little known of molecular mechanisms. New biomarkers that predict clinical outcome, in particular the ability primary tumor to develop tumors are urgently needed. The aim this study investigate role FLJ10540 human NPC development.A bioinformatics approach was used explore potentially important regulatory genes involved growth/metastasis control NPC. chosen study. Two co-expression strategies from...