A5032039501- Heat shock proteins research
- Asthma and respiratory diseases
- Interstitial Lung Diseases and Idiopathic Pulmonary Fibrosis
- Advanced Glycation End Products research
- Dermatology and Skin Diseases
- Inhalation and Respiratory Drug Delivery
- Wnt/β-catenin signaling in development and cancer
- Gut microbiota and health
- Allergic Rhinitis and Sensitization
- Occupational exposure and asthma
- Ferroptosis and cancer prognosis
- Cancer-related gene regulation
- ATP Synthase and ATPases Research
- Herbal Medicine Research Studies
- RNA modifications and cancer
- Healthcare and Venom Research
- Berberine and alkaloids research
- Cancer-related molecular mechanisms research
- Immune Cell Function and Interaction
- Pediatric health and respiratory diseases
- interferon and immune responses
- Oral health in cancer treatment
- Endoplasmic Reticulum Stress and Disease
- thermodynamics and calorimetric analyses
- Cancer, Hypoxia, and Metabolism
Southern Medical University
2016-2025
Nanfang Hospital
2016-2025
Northwest A&F University
2025
USC Norris Comprehensive Cancer Center
2016-2024
Henan University of Urban Construction
2016
University of Southern California
2015-2016
University of Illinois Chicago
2015
University of Science and Technology Beijing
2014
Polystyrene microplastics (PS-MPs) are new types of environmental pollutant that have garnered significant attention in recent years since they were found to cause damage the human respiratory system when inhaled. The pulmonary fibrosis is one serious consequences PS-MPs inhalation. However, impact and underlying mechanisms on not clear. In this study, we studied potential lung toxicity PS-MPs-developed by long-term intranasal inhalation PS-MPs. results showed after exposing PS-MPs, lungs...
Asthma is a disease characterized by airway epithelial barrier destruction, chronic inflammation, and remodeling. Repeated damage to cells allergens in the environment plays an important role pathophysiology of asthma. Ferroptosis novel form regulated cell death mediated lipid peroxidation association with free iron-mediated Fenton reactions. In this study, we explored contribution ferroptosis house dust mite (HDM)-induced asthma models. Our vivo vitro models showed labile iron accumulation...
When tissues are injured and blood vessels clotted, the local environment becomes ischemic – lack of adequate supply oxygen glucose delivered to surrounding cells. The heat shock protein-90 (Hsp90) family proteins protect from various environmental insults participate in damaged tissue repair. Here we report discovery a novel ischemia-responsive mechanism by which two Hsp90 isoforms, Hsp90α Hsp90β, work together promote cell motility wounded skin accelerate wound closure. We demonstrate that...
Both intracellular and extracellular heat shock protein-90 (Hsp90) family proteins (α β) have been shown to support tumour progression. The tumour-supporting activity of the Hsp90 is attributed their N-terminal ATPase-driven chaperone function. What molecular entity determines function secreted distinction between Hsp90α Hsp90β was unclear. Here we demonstrate that CRISPR/Case9 knocking out nullifies cells’ ability migrate, invade metastasize without affecting cell survival growth. Knocking...
Abstract Rapidly growing tumours in vivo often outgrow their surrounding available blood supply, subjecting themselves to a severely hypoxic microenvironment. Understanding how tumour cells adapt survive hypoxia may help develop new treatments of the tumours. Given limited perfusion enlarging tumour, whatever factor(s) that allows likely comes from or its associated stromal cells. In this report, we show HIF-1α-overexpressing breast cancer cells, MDA-MB-231, secrete heat shock...
Dapper homolog (DACT) 2 is one of the Dact gene family members, which are important modulators Wnt signaling pathway. We aim to clarify its epigenetic inactivation, biological function and clinical implication in colon cancer. DACT2 was silenced five out eight cancer cell lines, but robustly expressed normal tissues. The loss expression regulated by promoter hypermethylation. Restoring lines suppressed tumor growth inducing apoptosis inhibiting proliferation both vitro vivo. Moreover,...
Abstract Background The tumor microenvironment plays a key role in non-small cell lung cancer (NSCLC) development and also influences the effective response to immunotherapy. pro-inflammatory factor interleukin-17A mediates important immune responses microenvironment. In this study, potential mechanisms of IL-17A NSCLC were investigated. Methods We detected by immunohistochemistry (IHC) 39 patients. Its expression was correlated with programmed death-ligand1 (PD-L1). knockdown overexpression...
Microplastics pollution has raised a considerable awareness due to their extensive distribution in the environment. It potential side effects on human health. can enter respiratory system, then deposit lung, destroying structure of bronchus and alveoli, causing pulmonary inflammation, mucus production, airway hyperresponsiveness, leading aggravation asthma. Nevertheless, underlying mechanism remains elusive. There are several cytokines involved inflammatory response Heat shock protein...
ABSTRACT Lung cancer is a leading cause of mortality, with non-small cell lung (NSCLC) comprising the majority cases. Despite advent immune checkpoint inhibitors (ICIs), significant number patients fail to achieve durable response, highlighting need understand factors influencing treatment efficacy. Saliva samples and tumor were collected from 20 NSCLC patients. The salivary microbiota was profiled using metagenomic next-generation sequencing, metabolites analyzed via liquid...
ABSTRACT Asthma is a chronic respiratory disease with increasing global prevalence, often linked to disrupted airway microbiota. Azithromycin has shown promise in asthma treatment, but whether its effect owing antimicrobial capacity remains largely unknown. A house dust mite (HDM)-induced asthmatic mouse model was used evaluate the effects of azithromycin on inflammation and Mice were divided into control, HDM-induced asthma, HDM + azithromycin, azithromycin-alone groups. Airway microbiota...
Recent studies have indicated that high-mobility group box 1 protein (HMGB1) and the receptor for advanced glycation end-products (RAGE) contribute to pathogenesis of asthma. However, whether activation HMGB1/RAGE axis mediates airway epithelial barrier dysfunction remains unknown. Thus, aim this study was examine effects HMGB1 its synergistic action with interleukin (IL)-1β on properties. We evaluated recombinant human alone or in combination IL-1β ionic macromolecular permeability, by...
Aberrant activation of β-catenin signaling by both WNT-dependent and WNT-independent pathways has been demonstrated in asthmatic airways, which is thought to contribute critically remodeling the airways. Yet, exact role asthma very poorly defined. As we have previously reported abnormal expression a toluene diisocyanate (TDI)-induced model, this study, evaluated therapeutic efficacy two small molecules XAV-939 ICG-001 TDI-asthmatic male BALB/c mice, selectively block β-catenin-mediated...
Idiopathic pulmonary fibrosis is a progressive fatal disease characterized by interstitial remodeling, with high lethality and lack of effective medical therapies. Tetrandrine has been proposed to present anti-fibrotic effects, but the efficacy mechanisms have not systematically evaluated. We sought study potential therapeutic effects tetrandrine against lung fibrosis. The were evaluated in bleomycin-induced mouse models TGF-β1-stimulated murine fibroblasts. performed Chromatin...
Pulmonary fibrosis is characterized by lung fibroblast activation and ECM deposition has a poor prognosis. Heat shock protein 90 (Hsp90) participates in organ fibrosis, extracellular Hsp90α (eHsp90α) promotes migration. This study aimed to investigate whether selective anti-Hsp90α monoclonal antibody, 1G6-D7, could attenuate 1G6-D7 presents protective effect inactivating the profibrotic pathway. Our results showed that eHsp90α was increased mice with BLM-induced pulmonary attenuated...
Introduction Atherosclerosis is the main pathological change in diabetic angiopathy, and vascular inflammation plays an important role early atherosclerosis. Extracellular heat shock protein 90 (eHsp90) secreted into serum involved various physiological pathophysiological processes. However, specific mechanism of eHsp90 atherosclerosis remains unclear. This study explored relationship between Hsp90 lower extremity arterial disease investigated expression endothelial cells under environmental...
The disruption and hyperpermeability of bronchial epithelial barrier are closely related to the pathogenesis asthma. House dust mite (HDM), one most important allergens, could increase airway permeability. Heat shock protein (Hsp) 90α is also implicated in lung endothelial dysfunction by disrupting RhoA signaling. However, effect extracellular Hsp90α (eHsp90α) on induced HDM has never been reported.To investigate involvement eHsp90α HDM, normal human cell line 16HBE14o- (16HBE) cells were...
The loss of airway epithelial integrity contributes significantly to asthma pathogenesis. Evidence suggests that vitamin D plays an important role in the prevention and treatment asthma. However, its barrier function remains uncertain. We have previously demonstrated impaired junctions a model toluene diisocyanate (TDI)-induced In present study, we hypothesized 1,25-dihydroxyvitamin D3 [1,25(OH)2D3] may prevent TDI-induced disruption. Male BALB/c mice were dermally sensitized then challenged...
Thymic stromal lymphopoietin presents in two distinct isoforms: short-form (sfTSLP) and long-form (lfTSLP). lfTSLP promotes inflammation, whereas sfTSLP inhibits allergic asthma. However, little is known about the regulation of during attack asthma airway epithelium. Here, we report that small ubiquitin-like modifier (SUMOylation) was enhanced house dust mite-induced Inhibition SUMOylation significantly alleviated T-helper cell type 2 inflammation expression. Mechanistically, chromobox 4...