A5018682455- Diabetic Foot Ulcer Assessment and Management
- Heat shock proteins research
- Thyroid Cancer Diagnosis and Treatment
- Wound Healing and Treatments
- Orthopedic Infections and Treatments
- Diabetes Treatment and Management
- Dermatology and Skin Diseases
- Diabetes, Cardiovascular Risks, and Lipoproteins
- Asthma and respiratory diseases
- Intracerebral and Subarachnoid Hemorrhage Research
- Diabetes Management and Research
- Neurosurgical Procedures and Complications
- Acute Ischemic Stroke Management
- Chronic Kidney Disease and Diabetes
- Liver Disease Diagnosis and Treatment
- Chronic Obstructive Pulmonary Disease (COPD) Research
- Streptococcal Infections and Treatments
- Allergic Rhinitis and Sensitization
- Interstitial Lung Diseases and Idiopathic Pulmonary Fibrosis
- Autophagy in Disease and Therapy
- Advanced Neuroimaging Techniques and Applications
- Biomarkers in Disease Mechanisms
- Occupational exposure and asthma
- Cardiovascular Health and Disease Prevention
- Skin Diseases and Diabetes
Southern Medical University
2015-2024
Nanfang Hospital
2012-2024
First Affiliated Hospital of Guangzhou Medical University
2024
State Key Laboratory of Respiratory Disease
2024
Guangzhou Medical University
2024
The First Affiliated Hospital, Sun Yat-sen University
2024
Sun Yat-sen University
2024
USC Norris Comprehensive Cancer Center
2016-2024
Inner Mongolia University of Science and Technology
2024
The George Institute for Global Health
2015-2018
Abstract Regulation of excessive inflammation and impaired cell proliferation is crucial for healing diabetic wounds. Although plant‐to‐mammalian regulation offers effective approaches chronic wound management, the development a potent plant‐based therapeutic presents challenges. This study aims to validate efficacy turmeric‐derived nanoparticles (TDNPs) loaded with natural bioactive compounds. TDNPs can alleviate oxidative stress, promote fibroblast migration, reprogram macrophage...
When tissues are injured and blood vessels clotted, the local environment becomes ischemic – lack of adequate supply oxygen glucose delivered to surrounding cells. The heat shock protein-90 (Hsp90) family proteins protect from various environmental insults participate in damaged tissue repair. Here we report discovery a novel ischemia-responsive mechanism by which two Hsp90 isoforms, Hsp90α Hsp90β, work together promote cell motility wounded skin accelerate wound closure. We demonstrate that...
Abstract Loss of airway epithelial integrity contributes significantly to asthma pathogenesis. Thymic stromal lymphopoietin (TSLP) may have dual immunoregulatory roles. In inflammatory disorders the bowel, long isoform TSLP (lfTSLP) promotes inflammation while short (sfTSLP) inhibits inflammation. We hypothesize that lfTSLP house dust mite (HDM)-induced barrier dysfunction and synthetic sfTSLP can prevent these effects. vitro , function was assessed by monitoring transepithelial electrical...
Both intracellular and extracellular heat shock protein-90 (Hsp90) family proteins (α β) have been shown to support tumour progression. The tumour-supporting activity of the Hsp90 is attributed their N-terminal ATPase-driven chaperone function. What molecular entity determines function secreted distinction between Hsp90α Hsp90β was unclear. Here we demonstrate that CRISPR/Case9 knocking out nullifies cells’ ability migrate, invade metastasize without affecting cell survival growth. Knocking...
Abstract Rapidly growing tumours in vivo often outgrow their surrounding available blood supply, subjecting themselves to a severely hypoxic microenvironment. Understanding how tumour cells adapt survive hypoxia may help develop new treatments of the tumours. Given limited perfusion enlarging tumour, whatever factor(s) that allows likely comes from or its associated stromal cells. In this report, we show HIF-1α-overexpressing breast cancer cells, MDA-MB-231, secrete heat shock...
To assess the associations of diabetes duration and glycaemic control (defined by plasma glycated haemoglobin [HbA1c] level) with risks cardiovascular disease (CVD) all-cause mortality to determine whether addition either or both established CVD risk factors can improve predictions.A total 435 679 participants from UK Biobank without at baseline were included. Cox models adjusting for classic (sociodemographic anthropometric characteristics, lipid profiles medication use) used, predictive...
Aim The aim of this study is to explore the association between red blood cell distribution width–to–albumin ratio (RAR) and risk peripheral artery disease (PAD) in patients with diabetes. Methods This cross-sectional extracted data 1,125 participants diabetes from National Health Nutrition Examination Survey database. A weighted univariable logistic regression model was used variables associated PAD. With PAD as outcome variable, a established. odds (OR) 95% confidence interval (CI) were...
Objective: The 2017 American College of Cardiology/American Heart Association blood pressure (BP) guidelines lowered the hypertension threshold from a SBP/DBP level at least 140/90 mmHg to 130/80 mmHg. cardiovascular impact isolated systolic (ISH) and diastolic (IDH) under new definition remains unclear. Methods: We used data UK Biobank study, which is prospective population-based cohort study. Participants were categorized into five groups: normal BP, high ISH, IDH hypertension. primary...
Abstract Background To investigate the influence of diabetes duration and glycemic control, assessed by glycated hemoglobin (HbA1c) levels, on risk incident dementia. Methods The present study is a prospective 461 563 participants from UK Biobank. age at diagnosis was determined self-report. Diabetes calculated as baseline minus diagnosis. Cox proportional hazards regression models were used to estimate hazard ratios (HRs) with 95% confidential intervals (CIs). Results During median...
Abstract Papillary thyroid cancer (PTC) is one of the most common endocrine malignancies associated with significant morbidity and mortality. Although multiple studies have contributed to a better understanding genetic alterations underlying this frequently arising disease, downstream molecular effectors that impact PTC pathogenesis remain be further defined. Here, we report regulator cell fate specification, PROX1, becomes inactivated in through mRNA downregulation cytoplasmic...
Pulmonary fibrosis is characterized by lung fibroblast activation and ECM deposition has a poor prognosis. Heat shock protein 90 (Hsp90) participates in organ fibrosis, extracellular Hsp90α (eHsp90α) promotes migration. This study aimed to investigate whether selective anti-Hsp90α monoclonal antibody, 1G6-D7, could attenuate 1G6-D7 presents protective effect inactivating the profibrotic pathway. Our results showed that eHsp90α was increased mice with BLM-induced pulmonary attenuated...
Metagenome sequencing has not been used in infected bone specimens. This prospective observational study explored the microbiome and its function patients with diabetic foot osteomyelitis (DFO) posttraumatic (PFO) based on 16S rRNA metagenome technologies. Spearman analysis was to explore correlation between dominant species clinical indicators of DFO. High-throughput showed that all specimens were polymicrobial. The microbial diversity significantly higher DFO group than PFO group....
Emerging evidence indicates that hyperglycemia has an adverse impact on the knee joint which, in turn, may increase risk of osteoarthritis (OA), but from real-life settings large-scale cohort studies remains unclear. We sought to evaluate association glycemic control and symptomatic OA a community-based older adults.We conducted prospective analysis 10,730 participants without OA. Comprehensive blood biomarker data were obtained. Diabetes mellitus (DM) was defined mainly using glycosylated...
Introduction Atherosclerosis is the main pathological change in diabetic angiopathy, and vascular inflammation plays an important role early atherosclerosis. Extracellular heat shock protein 90 (eHsp90) secreted into serum involved various physiological pathophysiological processes. However, specific mechanism of eHsp90 atherosclerosis remains unclear. This study explored relationship between Hsp90 lower extremity arterial disease investigated expression endothelial cells under environmental...
Objectives Social isolation may affect diabetes self-management. This study aimed to explore the relations between social and glycaemic control in patients with lifestyle differences among individuals different levels of isolation. Methods The relevant data 665 people previously diagnosed included China Health Retirement Longitudinal Study from 2011 2015 were extracted analysed. patient general information, blood glucose, lipids, glycosylated haemoglobin, index, health-related factors...
Abstract Background Greater lipid variability may cause adverse health events among diabetic patients. We aimed to examine the effect of on risk microvascular outcomes type 2 diabetes mellitus Methods assessed association between visit‐to‐visit (measured by independent mean) in high‐density lipoprotein (HDL) cholesterol, low‐density lipoprotein‐cholesterol (LDL), triglyceride, and remnant cholesterol (RC) measurements participants involved Action Control Cardiovascular Risk Diabetes (ACCORD)...
The loss of airway epithelial integrity contributes significantly to asthma pathogenesis. Evidence suggests that vitamin D plays an important role in the prevention and treatment asthma. However, its barrier function remains uncertain. We have previously demonstrated impaired junctions a model toluene diisocyanate (TDI)-induced In present study, we hypothesized 1,25-dihydroxyvitamin D3 [1,25(OH)2D3] may prevent TDI-induced disruption. Male BALB/c mice were dermally sensitized then challenged...
<b><i>Background:</i></b> Cardiovascular outcomes in clinical trials with type 2 diabetes mellitus (T2DM) patients have shown that glucagon-like peptide-1 receptor agonist can a beneficial effect on the kidney. This trial aimed to assess effects of exenatide renal T2DM and diabetic kidney disease (DKD). <b><i>Methods:</i></b> We performed randomized parallel study encompassing 4 general hospitals. an estimated glomerular filtration rate (eGFR)...
Recent findings suggest that extracellular heat shock protein 90α (eHSP90α) promotes pulmonary fibrosis, but the underlying mechanisms are not well understood. Aging, especially cellular senescence, is a critical risk factor for idiopathic fibrosis (IPF). Here, we aim to investigate role of eHSP90α on senescence in IPF. Our results found was upregulated bleomycin (BLM)-induced mice, which correlated with expression markers. This increase mediated fibroblast and facilitated mitochondrial...