A5047470915- Thyroid Cancer Diagnosis and Treatment
- Adenosine and Purinergic Signaling
- Mesenchymal stem cell research
- Molecular Biology Techniques and Applications
- MicroRNA in disease regulation
- Estrogen and related hormone effects
- Cancer Cells and Metastasis
- Acute Kidney Injury Research
- Coagulation, Bradykinin, Polyphosphates, and Angioedema
- Extracellular vesicles in disease
- Epigenetics and DNA Methylation
- RNA Interference and Gene Delivery
- RNA Research and Splicing
- RNA modifications and cancer
- Glutathione Transferases and Polymorphisms
- Virus-based gene therapy research
- Immune cells in cancer
- Thyroid Disorders and Treatments
- Protein Kinase Regulation and GTPase Signaling
- Peptidase Inhibition and Analysis
- Genetics and Neurodevelopmental Disorders
- Neuroendocrine Tumor Research Advances
- COVID-19 Clinical Research Studies
- Intensive Care Unit Cognitive Disorders
- Long-Term Effects of COVID-19
Universidade Federal de Ciências da Saúde de Porto Alegre
2016-2025
Universidade Federal de Pelotas
2023
Universidade do Vale do Rio dos Sinos
2022-2023
Universidade Federal do Rio Grande do Sul
2014-2015
In the end of 2019 COVID-19 emerged as a new threat worldwide and this disease present impaired immune system, exacerbated production inflammatory cytokines, coagulation disturbs. Mesenchymal stem cell (MSC) derived extracellular vesicles (EVs) have therapeutic option due to its intrinsic properties alleviate responses, capable promote restoring injured tissue. EVs contain heterogeneous cargo, including active microRNAs, small noncoding sequences involved in post-transcriptional gene...
Abstract Papillary thyroid cancer (PTC) is one of the most common endocrine malignancies associated with significant morbidity and mortality. Although multiple studies have contributed to a better understanding genetic alterations underlying this frequently arising disease, downstream molecular effectors that impact PTC pathogenesis remain be further defined. Here, we report regulator cell fate specification, PROX1, becomes inactivated in through mRNA downregulation cytoplasmic...
Reverse transcription quantitative polymerase chain reaction (RT-qPCR) has been recognized as the most accurate method for quantifying mRNA transcripts, but normalization of samples is a prerequisite correct data interpretation. So, this study aimed to evaluate stable reference gene RT-qPCR in human normal thyroid and goiter tissues. Beta-actin (ACTB); glyceraldehyde-3-phosphate dehydrogenase (GAPDH); succinate dehydrogenase, subunit A, flavoprotein (Fp) (SDHA); hypoxanthine...
Abstract Background ZEB1, a core transcription factor involved in epithelial-mesenchymal transition (EMT), is associated with aggressive cancer cell behavior, treatment resistance, and poor prognosis across various tumor types. Similarly, the expression activity of CD73, an ectonucleotidase implicated adenosine generation, important marker malignancy. Growing evidence suggests that EMT adenosinergic pathway are intricately linked play pivotal role development. Therefore, this study focuses...
Human Limbal (L-MSCs) and Dermal Mesenchymal Stem Cell (D-MSCs) possess many properties that increase their therapeutic potential in ophthalmology dermatology. It is known purinergic signaling plays a role aspects of mesenchymal stem cells physiology. They release respond to ligands, altering proliferation, migration, differentiation, apoptosis. Therefore, more information on these processes would be crucial for establishing future clinical applications using differentiation potential, but...
Thyroid cancer and thyroid nodules are more prevalent in women than men, so female sex hormones may have an etiological role these conditions. There no data about direct effects of progesterone on cells, the aim present study was to evaluate sodium-iodide symporter NIS , thyroglobulin TG thyroperoxidase TPO KI-67 genes expression, normal follicular derived from human tissue. mRNA expression increased significantly after TSH 20 μ UI/mL, respectively: 2.08 times,<mml:math...
Vascular smooth muscle cells (VSMCs) exhibit a high degree of plasticity when they undergo the progression from normal to disease condition, which makes them potential target for evaluating early markers and development new therapies. Purinergic signalling plays key role in vascular tonus control, ATP being an inductor vasoconstriction, whereas adenosine mediates vasodilation effect antagonising actions. The control extracellular levels is done by ectonucleotidases, represent be evaluated...