A5025288094- Thyroid Cancer Diagnosis and Treatment
- Thyroid Disorders and Treatments
- Coagulation, Bradykinin, Polyphosphates, and Angioedema
- Thyroid and Parathyroid Surgery
- Growth Hormone and Insulin-like Growth Factors
- Head and Neck Anomalies
- Neuroendocrine Tumor Research Advances
- Viral Infections and Outbreaks Research
- Disaster Response and Management
- Cancer-related Molecular Pathways
- Salivary Gland Tumors Diagnosis and Treatment
- Healthcare Systems and Challenges
- Ophthalmology and Eye Disorders
- Vestibular and auditory disorders
- Porphyrin Metabolism and Disorders
- BRCA gene mutations in cancer
- Disaster Management and Resilience
- Muscle Physiology and Disorders
- Histone Deacetylase Inhibitors Research
- Biochemical and Molecular Research
- Genetic factors in colorectal cancer
- Estrogen and related hormone effects
- Ion channel regulation and function
- Women's cancer prevention and management
- S100 Proteins and Annexins
Universidade Federal de Ciências da Saúde de Porto Alegre
2013-2025
Santa Casa de Misericórdia de Marília
2017-2024
Irmandade da Santa Casa de Misericórdia de São Paulo
2020-2022
Centers for Disease Control and Prevention
2018
Emory University
2016
Universidade Federal do Rio Grande do Sul
2005-2012
Hospital de Clínicas de Porto Alegre
2008-2012
The single-nucleotide polymorphism A/G in the type 2 deiodinase (D2) gene predicts a threonine (Thr) to alanine (Ala) substitution at codon 92 (D2 Thr92Ala) and is associated with insulin resistance obese patients. Here, this association was investigated 183 patients diabetes mellitus, using homeostasis model assessment. median fasting plasma Ala/Ala individuals significantly higher than Ala/Thr or Thr/Thr genotypes (19.6 vs. 12.0 14.8 mIU/ml, respectively; P = 0.004). Assuming recessive...
Social mobilisation and risk communication were essential to the 2014–2015 West African Ebola response. By March 2015, >8500 cases 3370 deaths confirmed in Sierra Leone. Response efforts focused on ‘getting zero staying at zero’. A critical component of this plan was deepen sustain community engagement. Several national quantitative studies conducted during time revealed knowledge, personal prevention practices traditional burial procedures improved as outbreak waned, but healthcare...
INTRODUÇÃO: O hipertireoidismo é caracterizado pelo aumento da síntese e liberação dos hormônios tireoidianos pela glândula tireoide. A tireotoxicose refere-se à síndrome clínica decorrente do excesso de circulantes, secundário ao ou não. Este artigo descreve diretrizes baseadas em evidências clínicas para o manejo tireotoxicose. OBJETIVO: presente consenso, elaborado por especialistas brasileiros patrocinado Departamento Tireoide Sociedade Brasileira Endocrinologia Metabologia, visa abordar...
Thyroid hormone regulates a wide range of cellular activities, including the balance between cell proliferation and differentiation. The thyroid-hormone-inactivating type 3 deiodinase (DIO3, D3) has been shown to be reactivated in human neoplasias. Here, we evaluated DIO3 expression papillary thyroid carcinoma (PTC).Tumor surrounding normal tissue were collected from 26 unselected patients with PTC. Clinical data retrospectively reviewed medical records. mRNA levels measured by real-time...
Abstract Introduction Hemithyroidectomy is performed for the treatment of symptomatic unilateral benign nodules, cytologically indeterminate and some cases well-differentiated thyroid cancer. Objective To evaluate frequency postlobectomy hormone replacement (THR), to analyze clinical-pathological factors predicting L-thyroxine (T4) use in patients undergoing hemithyroidectomy. Methods We conducted an observational, retrospective study which clinical, biochemical, anatomopathological...
Risk stratification for persistent disease is an important step in pediatric differentiated thyroid cancer (DTC) management. The dynamic risk (DRS) a well validated system adults, but not yet children and adolescents. This study evaluated the DRS as other prognostic factors DTC.Patients aged ≤18 years from four DTC tertiary teaching hospitals Southern Brazil were included. Clinical characteristics systematically retrieved, all patients classified according to risk-stratification of 2015...
Summary Objective Type I iodothyronine deiodinase (D1) catalyses the 5′ monodeiodination of T4 and is highly expressed in normal human thyroid gland. We have investigated D1 expression a series benign malignant differentiated neoplasias. Design Surgically isolated tumour fragments were used. was determined by reverse transcription polymerase chain reaction (RT‐PCR) enzymatic assay. Patients Tumours adjacent tissues obtained from 28 unselected patients (papillary carcinoma, n = 14; follicular...
OBJECTIVE: The aim of this study was to evaluate the accuracy measurement thyroglobulin in washout needle aspiration biopsy (FNAB-Tg) detect papillary thyroid cancer (PTC) metastases. SUBJECTS AND METHODS: Forty-three patients (51.4 ± 14.6 years) with PTC diagnosis and evidence enlarged cervical lymph nodes (LN) were included. An ultrasound-guided fine-needle suspicious LN performed, for both cytological examination FNAB-Tg. RESULTS: median values FNAB-Tg metastatic (n = 5) 3,419 ng/mL...
Objective Ultrasonography (US) is the best diagnostic tool for initial assessment of thyroid nodule. Recently, data reporting systems lesions, such as Thyroid Imaging Reporting and Data System (TI-RADS) American Association (ATA), which stratifies risk malignancy, have demonstrated good performance in differentiating malignant nodules. The purpose this study to determine reliability both predicting malignancy a tertiary care hospital. Materials methods We evaluated 195 nodules using modified...
Abstract Objective Prospective data on the accuracy of ultrasound (US) classification systems in thyroid nodules are still scarce. The aim this study is to compare American College Radiology Thyroid Imaging Reporting and Data System (ACR‐TIRADS) European (EU)‐TIRADS systems. Design Patients Consecutive patients with one or more nodule(s) who underwent fine‐needle aspiration (FNA) under ultrasonographic guidance (FNA‐US) were prospectively evaluated. Measurements Clinical evaluation US...
The Ebola virus disease (Ebola) outbreak in West Africa began late 2013 Guinea (1) and spread unchecked during early 2014. By mid-2014, it had become the first epidemic ever documented. Transmission was occurring multiple districts of Guinea, Liberia, Sierra Leone, for time, capital cities (2). On August 8, 2014, World Health Organization (WHO) declared to be a Public Emergency International Concern (3). Ministries Health, with assistance from multinational collaborators, have reduced...
Abstract The clinical outcome of papillary thyroid carcinoma (PTC) patients with an indeterminate response after initial therapy is reported to be intermediate, between incomplete and excellent responses. This study evaluated the outcomes PTC therapy. It was further determined whether findings predicted more precisely. Patients were classified into 3 groups based on risk structural persistence/recurrence: Tg group: detectable thyroglobulin, negative antithyroglobulin antibody, regardless...
Even though it is a rare event, most associations of thyroid carcinoma with subacute thyroiditis described in the literature are related to its granulomatous form (Quervain's thyroiditis). We present patient lymphocytic (painless thyroiditis) and papillary cancer that was first suspected an initial ultrasound evaluation. A 30-year old female who referred emergency room due hyperthyroidism symptoms diagnosed painless established by physical examination laboratory findings. With presence...
This report describes how disruptions in routine immunizations because of the COVID-19 pandemic have elevated risk for increases vaccine-preventable diseases such as polio Africa and Philippines.
Thyroglobulin (Tg) is an important tool to evaluate the persistence and recurrence risk in differentiated thyroid cancer (DTC). We aimed correlation between pre-radioiodine therapy stimulated Tg (pre-RAI Tg) levels first response treatment evaluation, establish a cut-off pre-RAI threshold for predicting initial excellent response. Retrospective cohort study of DTC patients who underwent total thyroidectomy radioiodine therapy. Response was evaluated 6 24 months after therapy, were classified...
Multiple endocrine neoplasia type 2A (MEN2A) is an autosomal dominant inherited condition that predisposes to the triad of medullary thyroid cancer (MTC), pheochromocytoma (Pheo), and primary hyperparathyroidism (PHT). Nearly 100% MEN2A are associated with germ line mutation RET proto-oncogene (RET), DNA-based genotype analysis now considered essential for earlier diagnosis. The first manifestation most often due MTC, less frequently Pheo. Rarely, recognized during search PHT conditions....